Rv2453c

Tuberculist information
Gene namemobA
Protein functionProbable molybdopterin-guanine dinucleotide biosynthesis protein A MobA
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2753.02
Molecular mass(da)21052.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 201
	  		  	1    VAELAPDTVPLAGVVLAGGESRRMGRDKATLPLPGGTTTLVEHMVGILGQRCAPVFVMAA   60
			  	61   PGQPLPTLPVPVLRDELPGLGPLPATGRGLRAAAEAGVRLAFVCAVDMPYLTVELIEDLA  120
			  	121  RRAVQTDAEVVLPWDGRNHYLAAVYRTDLADRVDTLVGAGERKMSALVDASDALRIVMAD  180
			  	181  SRPLTNVNSAAGLHAPMQPGR

Known structures in the PDB
No Known structures
1 21 41 61 81 101 121 141 161 181 201 Range: 13 to 193  |  Coverage: 89% NTP_transf_3 Range: 11 to 189  |  Coverage: 88% 1 Range: 1 to 197  |  Coverage: 97% 1
Number of amino acids : 201
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
NTP_transf_3PF1280413-193
Mtb Structural Proteome models
Model Number1
Model nameRv2453c
Template1E5K    APDBCREDO
Template coverage7_183
Template Identity(%)31.6
Model coverage(%)88.6
Normalized DOPE score-0.693

Structure Models from Chopin
Model Number1
Profilec.68.1.8 - 3.90.550.10
Click for model details
zscore31.14
Residue begin1
Residue end197
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2453cGene nameConfidence Score
Rv0438cmoeA20.976
Rv0438cmoeA20.976
Rv0438cmoeA20.976
Rv2454cRv2454c0.968
Rv2452cRv2452c0.96
Rv2455cRv2455c0.953
Rv2455cRv2455c0.953
Rv2899cfdhD0.936
Rv0869cmoaA20.932
Rv0869cmoaA20.932
Rv0869cmoaA20.932
Rv3109moaA10.931
Rv3109moaA10.931
Rv3109moaA10.931
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
No high confidence interactions