Rv2454c

Tuberculist information
Gene nameRv2454c
Protein functionProbable oxidoreductase (beta subunit)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2753.62
Molecular mass(da)40143.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 373
	  		  	1    MTRSGDEAQLMTGVTGDLAGTELGLTPSLTKNAGVPTTDQPQKGKDFTSDQEVRWCPGCG   60
			  	61   DYVILNTIRNFLPELGLRRENIVFISGIGCSSRFPYYLETYGFHSIHGRAPAIATGLALA  120
			  	121  REDLSVWVVTGDGDALSIGGNHLIHALRRNINVTILLFNNRIYGLTKGQYSPTSEVGKVT  180
			  	181  KSTPMGSLDHPFNPVSLALGAEATFVGRALDSDRNGLTEVLRAAAQHRGAALVEILQDCP  240
			  	241  IFNDGSFDALRKEGAEERVIKVRHGEPIVFGANGEYCVVKSGFGLEVAKTADVAIDEIIV  300
			  	301  HDAQVDDPAYAFALSRLSDQNLDHTVLGIFRHISRPTYDDAARSQVVAARNAAPSGTAAL  360
			  	361  QSLLHGRDTWTVD

Known structures in the PDB
No Known structures
1 38 75 112 149 186 223 260 297 334 371 Range: 87 to 235  |  Coverage: 39% TPP_enzyme_C Range: 3 to 251  |  Coverage: 66% 1 Range: 1 to 373  |  Coverage: 99% 1
Number of amino acids : 373
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
TPP_enzyme_CPF0277587-235
Mtb Structural Proteome models
Model Number1
Model nameRv2454c
Template1UPA    APDBCREDO
Template coverage324_572
Template Identity(%)18.5
Model coverage(%)66.3
Normalized DOPE score-0.162

Structure Models from Chopin
Model Number1
Profilec.36.1.12
Click for model details
zscore10.91
Residue begin1
Residue end373
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2454cGene nameConfidence Score
Rv2455cRv2455c0.999
Rv2455cRv2455c0.999
Rv0951sucC0.991
Rv0951sucC0.991
Rv0952sucD0.99
Rv0952sucD0.99
Rv2453cmobA0.968
Rv0066cicd20.964
Rv2452cRv2452c0.962
Rv2215dlaT0.903
Rv2215dlaT0.903
Rv2215dlaT0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
alpha-ketoglutaratePubChem0.956146.098
succinyl-CoAPubChem0.95867.607