SInCRe - Rv0066c

Tuberculist information

Gene name	icd2
Protein function	Probable isocitrate dehydrogenase [NADP] Icd2 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	72.274
Molecular mass(da)	82550
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 745

	  		  	1    MSAEQPTIIYTLTDEAPLLATYAFLPIVRAFAEPAGIKIEASDISVAARILAEFPDYLTE   60
			  	61   EQRVPDNLAELGRLTQLPDTNIIKLPNISASVPQLVAAIKELQDKGYAVPDYPADPKTDQ  120
			  	121  EKAIKERYARCLGSAVNPVLRQGNSDRRAPKAVKEYARKHPHSMGEWSMASRTHVAHMRH  180
			  	181  GDFYAGEKSMTLDRARNVRMELLAKSGKTIVLKPEVPLDDGDVIDSMFMSKKALCDFYEE  240
			  	241  QMQDAFETGVMFSLHVKATMMKVSHPIVFGHAVRIFYKDAFAKHQELFDDLGVNVNNGLS  300
			  	301  DLYSKIESLPASQRDEIIEDLHRCHEHRPELAMVDSARGISNFHSPSDVIVDASMPAMIR  360
			  	361  AGGKMYGADGKLKDTKAVNPESTFSRIYQEIINFCKTNGQFDPTTMGTVPNVGLMAQQAE  420
			  	421  EYGSHDKTFEIPEDGVANIVDVATGEVLLTENVEAGDIWRMCIVKDAPIRDWVKLAVTRA  480
			  	481  RISGMPVLFWLDPYRPHENELIKKVKTYLKDHDTEGLDIQIMSQVRSMRYTCERLVRGLD  540
			  	541  TIAATGNILRDYLTDLFPILELGTSAKMLSVVPLMAGGGMYETGAGGSAPKHVKQLVEEN  600
			  	601  HLRWDSLGEFLALGAGFEDIGIKTGNERAKLLGKTLDAAIGKLLDNDKSPSRKTGELDNR  660
			  	661  GSQFYLAMYWAQELAAQTDDQQLAEHFASLADVLTKNEDVIVRELTEVQGEPVDIGGYYA  720
			  	721  PDSDMTTAVMRPSKTFNAALEAVQG

Known structures in the PDB

No Known structures

Number of amino acids : 745

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
IDH	PF03971	7-742

Mtb Structural Proteome models

Model Number	1
Model name	Rv0066c
Template	1ITW APDB CREDO
Template coverage	3_740
Template Identity(%)	61.2
Model coverage(%)	99.1
Normalized DOPE score	-1.357

Structure Models from Chopin

Model Number	1
Profile	c.77.1.2 Click for model details
zscore	111.1
Residue begin	4
Residue end	744

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv0066c	Gene name	Confidence Score
Rv3339c	icd1	0.99
Rv2454c	Rv2454c	0.964
Rv2455c	Rv2455c	0.96
Rv2455c	Rv2455c	0.96
Rv1475c	acn	0.953
Rv1475c	acn	0.953

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
NADPPubChem	0.993	744.413
isocitratePubChem	0.993	192.124
D-isocitratePubChem	0.983	192.124
alpha-ketoglutaratePubChem	0.945	146.098
NAD+PubChem	0.919	663.425
suc-coaPubChem	0.9	867.607
carbon dioxidePubChem	0.9	44.0095
hydroxyl radicalsPubChem	0.9	17.0073
coenzyme APubChem	0.9	767.534
dihydronicotinamide formycin dinucleotidePubChem	0.9	665.441
Co-APubChem	0.9	767.534
reduced nicotinamide adenine dinucleotidePubChem	0.9	665.441
NADP(H)PubChem	0.9	745.421
cis-aconitatePubChem	0.9	174.108
succinyl-CoAPubChem	0.9	867.607
glyoxylatePubChem	0.779	74.0355
manganesePubChem	0.756	54.938
magnesiumPubChem	0.748	24.305