Rv1475c

Tuberculist information
Gene nameacn
Protein functionProbable iron-regulated aconitate hydratase Acn (citrate hydro-lyase) (aconitase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1663.21
Molecular mass(da)102417
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 943
	  		  	1    VTSKSVNSFGAHDTLKVGEKSYQIYRLDAVPNTAKLPYSLKVLAENLLRNEDGSNITKDH   60
			  	61   IEAIANWDPKAEPSIEIQYTPARVVMQDFTGVPCIVDLATMREAIADLGGNPDKVNPLAP  120
			  	121  ADLVIDHSVIADLFGRADAFERNVEIEYQRNGERYQFLRWGQGAFDDFKVVPPGTGIVHQ  180
			  	181  VNIEYLASVVMTRDGVAYPDTCVGTDSHTTMVNGLGVLGWGVGGIEAEAAMLGQPVSMLI  240
			  	241  PRVVGFRLTGEIQPGVTATDVVLTVTEMLRQHGVVGKFVEFYGEGVAEVPLANRATLGNM  300
			  	301  SPEFGSTAAIFPIDEETIKYLRFTGRTPEQVALVEAYAKAQGMWHDPKHEPEFSEYLELN  360
			  	361  LSDVVPSIAGPKRPQDRIALAQAKSTFREQIYHYVGNGSPDSPHDPHSKLDEVVEETFPA  420
			  	421  SDPGQLTFANDDVATDETVHSAAAHADGRVSNPVRVKSDELGEFVLDHGAVVIAAITSCT  480
			  	481  NTSNPEVMLGAALLARNAVEKGLTSKPWVKTTIAPGSQVVNDYYDRSGLWPYLEKLGFYL  540
			  	541  VGYGCTTCIGNSGPLPEEISKAVNDNDLSVTAVLSGNRNFEGRINPDVKMNYLASPPLVI  600
			  	601  AYALAGTMDFDFQTQPLGQDKDGKNVFLRDIWPSQQDVSDTIAAAINQEMFTRNYADVFK  660
			  	661  GDDRWRNLPTPSGNTFEWDPNSTYVRKPPYFEGMTAKPEPVGNISGARVLALLGDSVTTD  720
			  	721  HISPAGAIKPGTPAARYLDEHGVDRKDYNSFGSRRGNHEVMIRGTFANIRLRNQLLDDVS  780
			  	781  GGYTRDFTQPGGPQAFIYDAAQNYAAQHIPLVVFGGKEYGSGSSRDWAAKGTLLLGVRAV  840
			  	841  IAESFERIHRSNLIGMGVIPLQFPEGKSASSLGLDGTEVFDITGIDVLNDGKTPKTVCVQ  900
			  	901  ATKGDGATIEFDAVVRIDTPGEADYYRNGGILQYVLRNILKSG

Known structures in the PDB
No Known structures
1 95 189 283 377 471 565 659 753 847 941 Range: 55 to 400  |  Coverage: 36% Aconitase Range: 434 to 606  |  Coverage: 18% Aconitase Range: 734 to 866  |  Coverage: 13% Aconitase_C Range: 23 to 941  |  Coverage: 97% 1 Range: 1 to 346  |  Coverage: 36% 1 Range: 1 to 346  |  Coverage: 36% 2 Range: 434 to 779  |  Coverage: 36% 3 Range: 734 to 866  |  Coverage: 13% 4 Range: 189 to 306  |  Coverage: 12% 5 Range: 243 to 360  |  Coverage: 12% 6 Range: 622 to 739  |  Coverage: 12% 7
Number of amino acids : 943
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AconitasePF0033055-400
AconitasePF00330434-606
Aconitase_CPF00694734-866
Mtb Structural Proteome models
Model Number1
Model nameRv1475c
Template2B3Y    APDBCREDO
Template coverage20_889
Template Identity(%)51.6
Model coverage(%)97.3
Normalized DOPE score-1.152

Structure Models from Chopin
Model Number1
Profilec.8.2.1, c.83.1.1
Click for model details
zscore62.03
Residue begin1
Residue end346
Model Number2
Profilec.83.1.1
Click for model details
zscore42.16
Residue begin1
Residue end346
Model Number3
Profilec.83.1.1
Click for model details
zscore42.16
Residue begin434
Residue end779
Model Number4
Profilec.8.2.1
Click for model details
zscore24.18
Residue begin734
Residue end866
Model Number5
Profile3.40.1060.10
Click for model details
zscore12.57
Residue begin189
Residue end306
Model Number6
Profile3.40.1060.10
Click for model details
zscore12.57
Residue begin243
Residue end360
Model Number7
Profile3.40.1060.10
Click for model details
zscore12.57
Residue begin622
Residue end739
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1475cGene nameConfidence Score
Rv1131prpC0.996
Rv0896gltA20.995
Rv3339cicd10.982
Rv0889ccitA0.979
Rv0467icl10.977
Rv1098cfum0.968
Rv1098cfum0.968
Rv0066cicd20.953
Rv1240mdh0.944
Rv1240mdh0.944
Rv2995cleuB0.934
Rv2498ccitE0.919
Rv1915aceAa0.915
Rv1248cRv1248c0.914
Rv1248cRv1248c0.914
Rv1248cRv1248c0.914
Rv3075cRv3075c0.907
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
isocitratePubChem0.989192.124
cis-aconitatePubChem0.981174.108
citratePubChem0.98192.124
alpha-ketoglutaratePubChem0.948146.098
glyoxylatePubChem0.93874.0355
oxaloacetatePubChem0.935132.072
succinatePubChem0.933118.088
acetyl-CoAPubChem0.923809.571
D-isocitratePubChem0.921192.124
NADPPubChem0.905744.413
carbon dioxidePubChem0.944.0095
NADP(H)PubChem0.9745.421
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
NAD+PubChem0.9663.425
H(+)PubChem0.92.01588
hydroxyl radicalsPubChem0.917.0073
Co-APubChem0.9767.534
coenzyme APubChem0.9767.534
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
acetyl coenzyme-APubChem0.9809.571
4Fe-4SPubChem0.8688.9179
Fe(III)PubChem0.78455.845
acetatePubChem0.74159.044
superoxidePubChem0.7133.0067