SInCRe - Rv0896

Tuberculist information

Gene name	gltA2
Protein function	Probable citrate synthase I GltA2
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	999.472
Molecular mass(da)	47946.4
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 431

	  		  	1    VADTDDTATLRYPGGEIDLQIVHATEGADGIALGPLLAKTGHTTFDVGFANTAAAKSSIT   60
			  	61   YIDGDAGILRYRGYPIDQLAEKSTFIEVCYLLIYGELPDTDQLAQFTGRIQRHTMLHEDL  120
			  	121  KRFFDGFPRNAHPMPVLSSVVNALSAYYQDALDPMDNGQVELSTIRLLAKLPTIAAYAYK  180
			  	181  KSVGQPFLYPDNSLTLVENFLRLTFGFPAEPYQADPEVVRALDMLFILHADHEQNCSTST  240
			  	241  VRLVGSSRANLFTSISGGINALWGPLHGGANQAVLEMLEGIRDSGDDVSEFVRKVKNREA  300
			  	301  GVKLMGFGHRVYKNYDPRARIVKEQADKILAKLGGDDSLLGIAKELEEAALTDDYFIERK  360
			  	361  LYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWIAHWREMHDEGDSKIGRPRQIYTGY  420
			  	421  TERDYVTIDAR

Known structures in the PDB

No Known structures

Number of amino acids : 431

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Citrate_synt	PF00285	48-413

Mtb Structural Proteome models

Model Number	1
Model name	Rv0896
Template	1K3P APDB CREDO
Template coverage	1_420
Template Identity(%)	53.1
Model coverage(%)	97.9
Normalized DOPE score	-0.631

Structure Models from Chopin

Model Number	1
Profile	a.103.1.1 Click for model details
zscore	52.41
Residue begin	1
Residue end	431

Model Number	2
Profile	1.10.580.10 Click for model details
zscore	37.98
Residue begin	53
Residue end	305

Model Number	3
Profile	1.10.230.10 Click for model details
zscore	18.67
Residue begin	269
Residue end	376

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv0896	Gene name	Confidence Score
Rv1475c	acn	0.995
Rv1475c	acn	0.995
Rv1240	mdh	0.991
Rv1240	mdh	0.991
Rv2215	dlaT	0.986
Rv2215	dlaT	0.986
Rv2215	dlaT	0.986
Rv2967c	pca	0.979
Rv2967c	pca	0.979
Rv2967c	pca	0.979
Rv2967c	pca	0.979
Rv2967c	pca	0.979
Rv2967c	pca	0.979
Rv2495c	bkdC	0.977
Rv2495c	bkdC	0.977
Rv2495c	bkdC	0.977
Rv1248c	Rv1248c	0.977
Rv1248c	Rv1248c	0.977
Rv1248c	Rv1248c	0.977
Rv0211	pckA	0.976
Rv2995c	leuB	0.969
Rv3859c	gltB	0.967
Rv3859c	gltB	0.967
Rv3859c	gltB	0.967
Rv3859c	gltB	0.967
Rv1837c	glcB	0.958
Rv1323	fadA4	0.953
Rv1323	fadA4	0.953
Rv1074c	fadA3	0.952
Rv1074c	fadA3	0.952
Rv0859	fadA	0.951
Rv0859	fadA	0.951
Rv0951	sucC	0.95
Rv0951	sucC	0.95
Rv3556c	fadA6	0.948
Rv3556c	fadA6	0.948
Rv3546	fadA5	0.942
Rv1493	mutB	0.942
Rv1493	mutB	0.942
Rv3546	fadA5	0.942
Rv2852c	mqo	0.939
Rv1659	argH	0.938
Rv1659	argH	0.938
Rv0243	fadA2	0.936
Rv0243	fadA2	0.936
Rv0952	sucD	0.935
Rv0952	sucD	0.935
Rv3319	sdhB	0.933
Rv3319	sdhB	0.933
Rv2332	mez	0.929
Rv2332	mez	0.929
Rv1867	Rv1867	0.922
Rv3523	ltp3	0.92
Rv0914c	Rv0914c	0.919
Rv0914c	Rv0914c	0.919
Rv1308	atpA	0.914
Rv3318	sdhA	0.914
Rv1308	atpA	0.914
Rv3318	sdhA	0.914
Rv1308	atpA	0.914
Rv1595	nadB	0.911
Rv1595	nadB	0.911
Rv3858c	gltD	0.91
Rv3858c	gltD	0.91
Rv2498c	citE	0.91
Rv3858c	gltD	0.91

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
citratePubChem	0.989	192.124
oxaloacetatePubChem	0.989	132.072
NAD+PubChem	0.974	663.425
coenzyme APubChem	0.966	767.534
glyoxylatePubChem	0.965	74.0355
acetyl-CoAPubChem	0.964	809.571
Co-APubChem	0.945	767.534
malatePubChem	0.942	134.087
phosphatePubChem	0.939	96.9872
pyruvic acidPubChem	0.937	88.0621
reduced nicotinamide adenine dinucleotidePubChem	0.928	665.441
phosphoenolpyruvatePubChem	0.922	168.042
carbon dioxidePubChem	0.917	44.0095
formatePubChem	0.917	45.0174
protiumPubChem	0.915	2.01576
cis-aconitatePubChem	0.912	174.108
acetyl coenzyme-APubChem	0.908	809.571
D-malatePubChem	0.907	134.087
malyl coenzyme APubChem	0.9	883.606
H(+)PubChem	0.9	2.01588
hydroxyl radicalsPubChem	0.9	17.0073
malyl-CoAPubChem	0.9	883.606
deuteriumPubChem	0.9	2.01588
dihydronicotinamide formycin dinucleotidePubChem	0.9	665.441
acetatePubChem	0.888	59.044
sulfatePubChem	0.786	96.0626
hydron sulfatePubChem	0.778	196.157