Rv0243

Tuberculist information
Gene namefadA2
Protein functionProbable acetyl-CoA acyltransferase FadA2 (3-ketoacyl-CoA thiolase) (beta-ketothiolase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)292.171
Molecular mass(da)46075.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 440
	  		  	1    VAPAAKNTSQTRRRVAVLGGNRIPFARSDGAYADASNQDMFTAALSGLVDRFGLAGERLD   60
			  	61   MVVGGAVLKHSRDFNLMRECVLGSELSPYTPAFDLQQACGTGLQAAIAAADGIAAGRYEV  120
			  	121  AAAGGVDTTSDPPIGLGDDLRRTLLKLRRSRSNVQRLKLVGTLPASLGVEIPANSEPRTG  180
			  	181  LSMGEHAAVTAKQMGIKRVDQDELAAASHRNMADAYDRGFFDDLVSPFLGLYRDDNLRPN  240
			  	241  SSVEKLATLRPVFGVKAGDATMTAGNSTPLTDGASVALLASEQWAEAHSLAPLAYLVDAE  300
			  	301  TAAVDYVNGNDGLLMAPTYAVPRLLARNGLSLQDFDFYEIHEAFASVVLAHLAAWESEEY  360
			  	361  CKRRLGLDAALGSIDRSKLNVNGSSLAAGHPFAATGGRILAQTAKQLAEKKAAKKGGGPL  420
			  	421  RGLISICAAGGQGVAAILEA

Known structures in the PDB
No Known structures
1 45 89 133 177 221 265 309 353 397 441 Range: 12 to 283  |  Coverage: 61% Thiolase_N Range: 290 to 440  |  Coverage: 34% Thiolase_C Range: 14 to 439  |  Coverage: 96% 1 Range: 12 to 283  |  Coverage: 61% 1
Number of amino acids : 440
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Thiolase_NPF0010812-283
Thiolase_CPF02803290-440
Mtb Structural Proteome models
Model Number1
Model nameRv0243
Template1ULQ    APDBCREDO
Template coverage3_398
Template Identity(%)33.8
Model coverage(%)96.6
Normalized DOPE score0.277

Structure Models from Chopin
Model Number1
Profilec.95.1.1
Click for model details
zscore36.94
Residue begin12
Residue end283
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0243Gene nameConfidence Score
Rv0860fadB0.994
Rv0860fadB0.994
Rv0860fadB0.994
Rv0241chtdX0.959
Rv0241chtdX0.959
Rv0242cfabG40.954
Rv3140fadE230.949
Rv2504cscoA0.949
Rv3140fadE230.949
Rv0468fadB20.948
Rv0468fadB20.948
Rv2724cfadE200.939
Rv2724cfadE200.939
Rv2724cfadE200.939
Rv0896gltA20.936
Rv0975cfadE130.933
Rv0975cfadE130.933
Rv0975cfadE130.933
Rv0408pta0.931
Rv0408pta0.931
Rv0408pta0.931
Rv2503cscoB0.93
Rv3667acs0.929
Rv3667acs0.929
Rv3535chsaG0.921
Rv3535chsaG0.921
Rv2790cltp10.92
Rv2790cltp10.92
Rv1715fadB30.917
Rv1715fadB30.917
Rv0154cfadE20.916
Rv0154cfadE20.916
Rv0154cfadE20.916
Rv0131cfadE10.913
Rv0131cfadE10.913
Rv0131cfadE10.913
Rv0889ccitA0.912
Rv1131prpC0.911
Rv0873fadE100.91
Rv0873fadE100.91
Rv0873fadE100.91
Rv0904caccD30.906
Rv1837cglcB0.903
Rv0632cechA30.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetoacetyl-CoAPubChem0.939851.607
acetyl-CoAPubChem0.927809.571
3-ketohexanoyl-CoAPubChem0.914879.661
coenzyme APubChem0.913767.534
3-hydroxyhexadecanoyl-CoAPubChem0.9091021.94
myristoyl-CoAPubChem0.906977.89
Co-APubChem0.901767.534
NAD+PubChem0.901663.425
C05280PubChem0.9945.805
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
3-oxododecanoyl-coenzyme APubChem0.9963.82
C05263PubChem0.9963.82
CO8PubChem0.9893.73
Chebi:28726PubChem0.9991.873
CHEBI:27466PubChem0.9993.889
3-oxooctanoyl-CoAPubChem0.9907.714
octanoyl-CoAPubChem0.9893.73
3-Ketohexanoyl-coenzyme APubChem0.9879.661
decanoyl-CoAPubChem0.9921.783
CHEBI:28387PubChem0.9945.805
trans-2-hexadecenoyl-CoAPubChem0.91003.93
1,5-dihydro-FADPubChem0.9787.566
3-oxodecanoyl-coenzyme APubChem0.9935.767
beta-ketopalmitoyl-CoAPubChem0.91019.93
decanoyl coenzyme APubChem0.9921.783
C05279PubChem0.9945.805
CHEBI:28002PubChem0.9945.805
C05260PubChem0.9993.889
butyryl-CoAPubChem0.9837.624
AcCoAPubChem0.9809.571
4-cis-decenoyl-CoAPubChem0.9919.768
hydroxyl radicalsPubChem0.917.0073
CHEBI:27721PubChem0.9975.874
C05265PubChem0.9935.767
18:2(n-6)PubChem0.91029.96
hexanoyl-coenzyme APubChem0.9865.677
H(+)PubChem0.92.01588
hexanoyl-CoAPubChem0.9865.677
CHEBI:27402PubChem0.91021.94
flavin adenine dinucleotidePubChem0.9785.55
CHEBI:57385PubChem0.9977.89
butyryl coenzyme APubChem0.9837.624
lauroyl-CoAPubChem0.9949.837
n-C16:1CoAPubChem0.91003.93
C05273PubChem0.9975.874
deuteriumPubChem0.92.01588
3-oxooctanoyl-coenzyme APubChem0.9907.714
lauroyl-coenzyme APubChem0.9949.837