Rv0860

Tuberculist information
Gene namefadB
Protein functionProbable fatty oxidation protein FadB
Functional category(tuberculist)lipid metabolism
Gene location(kb)956.293
Molecular mass(da)76104.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 720
	  		  	1    MPDNTIQWDKDADGIVTLTMDDPSGSTNVMNEAYIESMGKAVDRLVAEKDSITGVVVASA   60
			  	61   KKTFFAGGDVKTMIQARPEDAGDVFNTVETIKRQLRTLETLGKPVVAAINGAALGGGLEI  120
			  	121  ALACHHRIAADVKGSQLGLPEVTLGLLPGGGGVTRTVRMFGIQNAFVSVLAQGTRFKPAK  180
			  	181  AKEIGLVDELVATVEELVPAAKAWIKEELKANPDGAGVQPWDKKGYKMPGGTPSSPGLAA  240
			  	241  ILPSFPSNLRKQLKGAPMPAPRAILAAAVEGAQVDFDTASRIESRYFASLVTGQVAKNMM  300
			  	301  QAFFFDLQAINAGGSRPEGIGKTPIKRIGVLGAGMMGAGIAYVSAKAGYEVVLKDVSLEA  360
			  	361  AAKGKGYSEKLEAKALERGRTTQERSDALLARITPTADAADFKGVDFVIEAVFENQELKH  420
			  	421  KVFGEIEDIVEPNAILGSNTSTLPITGLATGVKRQEDFIGIHFFSPVDKMPLVEIIKGEK  480
			  	481  TSDEALARVFDYTLAIGKTPIVVNDSRGFFTSRVIGTFVNEALAMLGEGVEPASIEQAGS  540
			  	541  QAGYPAPPLQLSDELNLELMHKIAVATRKGVEDAGGTYQPHPAEAVVEKMIELGRSGRLK  600
			  	601  GAGFYEYADGKRSGLWPGLRETFKSGSSQPPLQDMIDRMLFAEALETQKCLDEGVLTSTA  660
			  	661  DANIGSIMGIGFPPWTGGSAQFIVGYSGPAGTGKAAFVARARELAAAYGDRFLPPESLLS  720

Known structures in the PDB
PDB ID4B3H
Total residue count2278
Number of chains4
MethodX-RAY
Resolution2.3
PDB ID4B3I
Total residue count2278
Number of chains4
MethodX-RAY
Resolution2.63
PDB ID4B3J
Total residue count2278
Number of chains4
MethodX-RAY
Resolution2.5
1 73 145 217 289 361 433 505 577 649 721 Range: 9 to 254  |  Coverage: 34% ECH Range: 327 to 506  |  Coverage: 24% 3HCDH_N Range: 508 to 607  |  Coverage: 13% 3HCDH Range: 5 to 718  |  Coverage: 99% 1 Range: 322 to 608  |  Coverage: 39% 1 Range: 1 to 330  |  Coverage: 45% 2 Range: 503 to 631  |  Coverage: 17% 3
Number of amino acids : 720
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ECHPF003789-254
3HCDH_NPF02737327-506
3HCDHPF00725508-607
Mtb Structural Proteome models
Model Number1
Model nameRv0860
Template1WDK    APDBCREDO
Template coverage7_703
Template Identity(%)32.8
Model coverage(%)99.0
Normalized DOPE score-0.553

Structure Models from Chopin
Model Number1
Profilea.100.1.3, c.2.1.6 - 1.10.1040.10, 3.40.50.720
Click for model details
zscore42.46
Residue begin322
Residue end608
Model Number2
Profilec.14.1.3 - 3.90.226.10
Click for model details
zscore15.98
Residue begin1
Residue end330
Model Number3
Profilea.100.1.3
Click for model details
zscore11.55
Residue begin503
Residue end631
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0860Gene nameConfidence Score
Rv0859fadA0.999
Rv0859fadA0.999
Rv0243fadA20.994
Rv0243fadA20.994
Rv1074cfadA30.978
Rv1074cfadA30.978
Rv1323fadA40.976
Rv1323fadA40.976
Rv2724cfadE200.973
Rv2724cfadE200.973
Rv3556cfadA60.973
Rv2724cfadE200.973
Rv3556cfadA60.973
Rv3546fadA50.968
Rv3546fadA50.968
Rv0244cfadE50.967
Rv0244cfadE50.967
Rv0244cfadE50.967
Rv0244cfadE50.967
Rv0244cfadE50.967
Rv1467cfadE150.965
Rv1467cfadE150.965
Rv1467cfadE150.965
Rv1467cfadE150.965
Rv1467cfadE150.965
Rv0672fadE80.963
Rv0672fadE80.963
Rv0873fadE100.956
Rv0873fadE100.956
Rv1071cechA90.956
Rv1472echA120.956
Rv0873fadE100.956
Rv1071cechA90.956
Rv1550fadD110.956
Rv0971cechA70.947
Rv3274cfadE250.946
Rv3274cfadE250.946
Rv3274cfadE250.946
Rv0468fadB20.946
Rv0468fadB20.946
Rv1142cechA100.942
Rv0632cechA30.94
Rv2500cfadE190.94
Rv2500cfadE190.94
Rv2500cfadE190.94
Rv0905echA60.937
Rv0400cfadE70.934
Rv0400cfadE70.934
Rv0400cfadE70.934
Rv2831echA160.933
Rv1715fadB30.933
Rv1715fadB30.933
Rv3774echA210.931
Rv0752cfadE90.93
Rv0752cfadE90.93
Rv0752cfadE90.93
Rv0673echA40.929
Rv0222echA10.928
Rv1070cechA80.928
Rv0975cfadE130.927
Rv0975cfadE130.927
Rv0975cfadE130.927
Rv2790cltp10.924
Rv2790cltp10.924
Rv0154cfadE20.924
Rv3761cfadE360.924
Rv0154cfadE20.924
Rv0154cfadE20.924
Rv0215cfadE30.922
Rv0215cfadE30.922
Rv0215cfadE30.922
Rv3550echA200.92
Rv0753cmmsA0.92
Rv0231fadE40.919
Rv0231fadE40.919
Rv3140fadE230.919
Rv3140fadE230.919
Rv1679fadE160.917
Rv1679fadE160.917
Rv1679fadE160.917
Rv3516echA190.916
Rv2589gabT0.916
Rv0675echA50.915
Rv3039cechA170.915
Rv2503cscoB0.914
Rv3139fadE240.913
Rv1141cechA110.913
Rv3139fadE240.913
Rv3139fadE240.913
Rv0147Rv01470.911
Rv2789cfadE210.911
Rv3560cfadE300.911
Rv2504cscoA0.911
Rv2789cfadE210.911
Rv3560cfadE300.911
Rv2789cfadE210.911
Rv3560cfadE300.911
Rv1934cfadE170.909
Rv1934cfadE170.909
Rv1934cfadE170.909
Rv3373echA180.909
Rv0458Rv04580.909
Rv3504fadE260.909
Rv3797fadE350.909
Rv3504fadE260.909
Rv3797fadE350.909
Rv3504fadE260.909
Rv3543cfadE290.908
Rv3543cfadE290.908
Rv3543cfadE290.908
Rv0972cfadE120.908
Rv0972cfadE120.908
Rv0972cfadE120.908
Rv1933cfadE180.907
Rv2858caldC0.907
Rv1933cfadE180.907
Rv0768aldA0.906
Rv3562fadE310.905
Rv3562fadE310.905
Rv3562fadE310.905
Rv0456cechA20.905
Rv2486echA140.905
Rv2679echA150.905
Rv2502caccD10.904
Rv3061cfadE220.901
Rv3061cfadE220.901
Rv3061cfadE220.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetoacetyl-CoAPubChem0.962851.607
3-hydroxybutyryl-CoAPubChem0.959853.623
coenzyme APubChem0.958767.534
Co-APubChem0.943767.534
crotonyl-CoAPubChem0.93835.608
NAD+PubChem0.929663.425
3-oxooctanoyl-CoAPubChem0.927907.714
2-methyl-3-hydroxybutyryl-CoAPubChem0.925867.65
3-oxohexadecanoyl-CoAPubChem0.9211019.93
3-hydroxypropionyl-coenzyme APubChem0.92839.597
beta-ketopalmitoyl-CoAPubChem0.921019.93
3-hydroxydecanoyl-CoAPubChem0.918937.783
acetyl-CoAPubChem0.916809.571
decanoyl-CoAPubChem0.914921.783
myristoyl-CoAPubChem0.907977.89
hydroxyl radicalsPubChem0.90317.0073
C16469PubChem0.9893.687
trans-2-hexadecenoyl-CoAPubChem0.91003.93
C14145PubChem0.9911.659
trans-2-enoyl-CoAsPubChem0.9821.581
decanoyl coenzyme APubChem0.9921.783
c1137PubChem0.9875.672
CHEBI:28002PubChem0.9945.805
C05268PubChem0.9881.677
3-hydroxypropionyl-CoAPubChem0.9839.597
NSC112207PubChem0.9785.55
3-methylcrotonyl-CoAPubChem0.9849.635
C05276PubChem0.9891.714
C06002PubChem0.9102.089
C05260PubChem0.9993.889
acryloyl-CoAPubChem0.9821.581
flavin adenine dinucleotidePubChem0.9785.55
CHEBI:15489PubChem0.9837.581
c1139PubChem0.9891.671
CHEBI:27721PubChem0.9975.874
AcCoAPubChem0.9809.571
methylcrotonyl CoAPubChem0.9849.635
H(+)PubChem0.92.01588
butyryl-CoAPubChem0.9837.624
C05280PubChem0.9945.805
C11946PubChem0.9917.752
C05263PubChem0.9963.82
FADH2PubChem0.9787.566
deuteriumPubChem0.92.01588
CHEBI:27402PubChem0.91021.94
c0887PubChem0.9935.767
hexanoyl-coenzyme APubChem0.9865.677
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
C0885PubChem0.9917.752
CHEBI:15477PubChem0.9851.651
C05265PubChem0.9935.767
C04405PubChem0.9867.65
2MCPubChem0.9835.608
2-methylacetoacetyl-coenzyme APubChem0.9865.634
2-methylbutyryl-CoAPubChem0.9851.651
C16468PubChem0.9875.672
C05271PubChem0.9863.661
C11945PubChem0.9917.752
butyryl coenzyme APubChem0.9837.624
octanoyl-CoAPubChem0.9893.73
Chebi:28726PubChem0.9991.873
3-oxooctanoyl-coenzyme APubChem0.9907.714
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
acetyl coenzyme-APubChem0.9809.571
3-hydroxyadipyl-CoAPubChem0.9911.659
C16471PubChem0.9891.671
C05273PubChem0.9975.874
protiumPubChem0.92.01576
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
lauroyl-coenzyme APubChem0.9949.837
c1138PubChem0.9893.687
3-oxododecanoyl-coenzyme APubChem0.9963.82
3-ketohexanoyl-CoAPubChem0.9879.661
C11947PubChem0.9935.767
AR-1A9122PubChem0.9787.566
C05279PubChem0.9945.805
C05261PubChem0.9991.873
C05262PubChem0.9965.836
C01144PubChem0.9853.623
1,5-dihydro-FADPubChem0.9787.566
n-C16:1CoAPubChem0.91003.93
CHEBI:27466PubChem0.9993.889
C05989PubChem0.9837.581
CO8PubChem0.9893.73
hexanoyl-CoAPubChem0.9865.677
AR-1H5729PubChem0.9835.608
methylmalonate semialdehydePubChem0.9102.089
C03221PubChem0.9947.821
CHEBI:57385PubChem0.9977.89
methacrylyl-CoAPubChem0.9835.608
isobutyryl-CoAPubChem0.9837.624
2-methylacetoacetyl-CoAPubChem0.9865.634
CHEBI:28387PubChem0.9945.805
C05275PubChem0.9919.768
3-Ketohexanoyl-coenzyme APubChem0.9879.661
lauroyl-CoAPubChem0.9949.837
18:2(n-6)PubChem0.91029.96
4-cis-decenoyl-CoAPubChem0.9919.768
3-oxodecanoyl-coenzyme APubChem0.9935.767
C05266PubChem0.9909.73
C05258PubChem0.91021.94
alpha-methylbutyryl-CoAPubChem0.9851.651