Rv0456c

Tuberculist information
Gene nameechA2
Protein functionenoyl-CoA hydratase EchA2 (enoyl hydrase) (unsaturated acyl-CoA hydratase) (crotonase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)545.889
Molecular mass(da)33085.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 304
	  		  	1    MPTPDFQTLLYTTAGPVATITLNRPEQLNTIVPPMPDEIEAAIGLAERDQDIKVIVLRGA   60
			  	61   GRAFSGGYDFGGGFQHWGDAMMTDGRWDPGKDFAMVTARETGPTQKFMAIWRASKPVIAQ  120
			  	121  VHGWCVGGASDYALCADIVIASEDAVIGTPYSRMWGAYLTGMWLYRLSLAKVKWHSLTGR  180
			  	181  PLTGVQAAEAELINEAVPFERLEARVAEIATELARIPLSQLQAQKLIVNQAYENMGLAST  240
			  	241  QLLGGILDGLMRNTPDALEFIRTAQTQGVRAAVERRDGPFGDYSQAPPELRPDPTHVITP  300
			  	301  DGSM

Known structures in the PDB
No Known structures
1 31 61 91 121 151 181 211 241 271 301 Range: 10 to 244  |  Coverage: 76% ECH Range: 6 to 285  |  Coverage: 91% 1 Range: 1 to 304  |  Coverage: 99% 1
Number of amino acids : 304
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ECHPF0037810-244
Mtb Structural Proteome models
Model Number1
Model nameRv0456c
Template1DCI    APDBCREDO
Template coverage54_326
Template Identity(%)20.1
Model coverage(%)91.8
Normalized DOPE score0.094

Structure Models from Chopin
Model Number1
Profilec.14.1.3 - 3.90.226.10
Click for model details
zscore34.4
Residue begin1
Residue end304
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0456cGene nameConfidence Score
Rv1933cfadE180.946
Rv1933cfadE180.946
Rv1934cfadE170.942
Rv1679fadE160.942
Rv1934cfadE170.942
Rv1679fadE160.942
Rv3562fadE310.942
Rv1679fadE160.942
Rv3562fadE310.942
Rv3562fadE310.942
Rv1934cfadE170.942
Rv3564fadE330.94
Rv3564fadE330.94
Rv1467cfadE150.937
Rv0231fadE40.937
Rv0131cfadE10.937
Rv0231fadE40.937
Rv0131cfadE10.937
Rv1467cfadE150.937
Rv0131cfadE10.937
Rv1467cfadE150.937
Rv1467cfadE150.937
Rv1467cfadE150.937
Rv3505fadE270.934
Rv0271cfadE60.934
Rv0271cfadE60.934
Rv0271cfadE60.934
Rv3505fadE270.934
Rv0154cfadE20.932
Rv0154cfadE20.932
Rv0154cfadE20.932
Rv3563fadE320.931
Rv3560cfadE300.931
Rv3543cfadE290.931
Rv3560cfadE300.931
Rv3543cfadE290.931
Rv3543cfadE290.931
Rv3563fadE320.931
Rv3560cfadE300.931
Rv3504fadE260.93
Rv3504fadE260.93
Rv3544cfadE280.93
Rv3504fadE260.93
Rv3544cfadE280.93
Rv0860fadB0.905
Rv0860fadB0.905
Rv0860fadB0.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
C05268PubChem0.9881.677
3-methylcrotonyl-CoAPubChem0.9849.635
C01144PubChem0.9853.623
C0885PubChem0.9917.752
methylcrotonyl CoAPubChem0.9849.635
C11946PubChem0.9917.752
c0887PubChem0.9935.767
3-hydroxybutyryl-CoAPubChem0.9853.623
C04405PubChem0.9867.65
c1138PubChem0.9893.687
3-hydroxyhexadecanoyl-CoAPubChem0.91021.94
C16469PubChem0.9893.687
C05271PubChem0.9863.661
deuteriumPubChem0.92.01588
3-hydroxypropionyl-CoAPubChem0.9839.597
C05262PubChem0.9965.836
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65
H(+)PubChem0.92.01588
C05273PubChem0.9975.874
NAD+PubChem0.9663.425
C11945PubChem0.9917.752
C05266PubChem0.9909.73
3-hydroxyadipyl-CoAPubChem0.9911.659
acryloyl-CoAPubChem0.9821.581
C03221PubChem0.9947.821
hydroxyl radicalsPubChem0.917.0073
protiumPubChem0.92.01576
3-hydroxypropionyl-coenzyme APubChem0.9839.597
butyryl-CoAPubChem0.9837.624
methacrylyl-CoAPubChem0.9835.608
c1137PubChem0.9875.672
trans-2-enoyl-CoAsPubChem0.9821.581
C16468PubChem0.9875.672
C05275PubChem0.9919.768
crotonyl-CoAPubChem0.9835.608
C05258PubChem0.91021.94
C05260PubChem0.9993.889
[(2S,5S)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[[[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-[2-(1-oPubChem0.9833.592
acetoacetyl-S-CoAPubChem0.9851.607
trans-2-hexadecenoyl-CoAPubChem0.91003.93
2MCPubChem0.9835.608
C11947PubChem0.9935.767
3-hydroxydecanoyl-CoAPubChem0.9937.783
acetoacetyl-CoAPubChem0.9851.607
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
C05276PubChem0.9891.714
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
C14145PubChem0.9911.659