Rv0231

Tuberculist information
Gene namefadE4
Protein functionProbable acyl-CoA dehydrogenase FadE4
Functional category(tuberculist)lipid metabolism
Gene location(kb)276.058
Molecular mass(da)63494.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 568
	  		  	1    MLLNPNHLTRKYPDRRSGEIMAATVDFFESRGKARLKHDDHERIWYSDFLDFVGRERIFA   60
			  	61   SLLTPASYGADDCRWDTYRISEFAEIMGFYGLSYWYPFQVTALGLGPIWMSANEDAKRKA  120
			  	121  AAGLEAGEVFAFGLSEQTHGADVYQTDMILTPSDGGWTANGEKYYIGNANVARMVSTFGK  180
			  	181  IAGTPESQEYVFFVADSQHERYDLIKNVVNSQNYVANYALRDYPVTEADILHRGAEAFHA  240
			  	241  ALNTVNVCKYNLGWGAIGMCTHALYESVTHAANRHLYGTVVTDFSHVRRLLTDAYVRLIA  300
			  	301  MKLVASRASDYMRSASAADRRYLLYSPLTKAKVTSEGERVITALWDVIAAKGVEKDTFFE  360
			  	361  TVAREIGLLPRLEGTVHINIGLLGKFMPNYLFAPDSTLPVIPRRDDAADDAFLFAQGPTG  420
			  	421  GLGKVRFHDWRASFDTCAHLPNVALLREQVDVFAELLASATPDAAQQKDIDFAFGVGQLF  480
			  	481  ANVPYAQLILEEARLSGVDEALIDEIFGVLVRDFNTHAVELHGRSATTAEQARFAMRMVR  540
			  	541  RPVHDPARYDQIWKDHVLALNGAYQMAP

Known structures in the PDB
No Known structures
1 57 113 169 225 281 337 393 449 505 561 Range: 131 to 183  |  Coverage: 9% Acyl-CoA_dh_M Range: 236 to 387  |  Coverage: 26% Acyl-CoA_dh_1 Range: 11 to 388  |  Coverage: 66% 1 Range: 3 to 568  |  Coverage: 99% 2 Range: 8 to 396  |  Coverage: 68% 1 Range: 1 to 524  |  Coverage: 92% 2 Range: 236 to 387  |  Coverage: 26% 3 Range: 118 to 247  |  Coverage: 22% 4 Range: 1 to 248  |  Coverage: 43% 5
Number of amino acids : 568
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_MPF02770131-183
Acyl-CoA_dh_1PF00441236-387
Mtb Structural Proteome models
Model Number1
Model nameRv0231
Template2D29    APDBCREDO
Template coverage3_384
Template Identity(%)19.3
Model coverage(%)66.4
Normalized DOPE score-0.643

Model Number2
Model nameRv0231.1
Template2DDH    APDBCREDO
Template coverage14_619
Template Identity(%)9.2
Model coverage(%)99.5
Normalized DOPE score0.351

Structure Models from Chopin
Model Number1
Profile1.20.140.10, 2.40.110.10
Click for model details
zscore44.83
Residue begin8
Residue end396
Model Number2
Profilea.29.3.1, e.6.1.1
Click for model details
zscore40.71
Residue begin1
Residue end524
Model Number3
Profilea.29.3.1
Click for model details
zscore30.81
Residue begin236
Residue end387
Model Number4
Profile2.40.110.10
Click for model details
zscore15.46
Residue begin118
Residue end247
Model Number5
Profilee.6.1.2
Click for model details
zscore9.15
Residue begin1
Residue end248
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0231Gene nameConfidence Score
Rv2679echA150.937
Rv0456cechA20.937
Rv1135ARv1135A0.934
Rv0675echA50.934
Rv1935cechA130.931
Rv0673echA40.931
Rv3561fadD30.93
Rv1071cechA90.93
Rv1071cechA90.93
Rv2831echA160.93
Rv1141cechA110.93
Rv3550echA200.93
Rv3561fadD30.93
Rv1142cechA100.928
Rv0753cmmsA0.921
Rv0222echA10.92
Rv0632cechA30.92
Rv0971cechA70.92
Rv0860fadB0.919
Rv0860fadB0.919
Rv0860fadB0.919
Rv3516echA190.915
Rv0859fadA0.911
Rv0859fadA0.911
Rv3774echA210.911
Rv1867Rv18670.91
Rv3667acs0.907
Rv3667acs0.907
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv0231.141xkk_FMM_A_91PDBCREDO0.6270.1480.5150.009
Rv0231.143sm2_478_A_126PDBCREDO0.5960.1840.5150.009
Rv0231.142v0z_C41_C_1328PDBCREDO0.5910.1900.5110.009
Rv0231.142v0z_C41_O_1327PDBCREDO0.6270.1480.5020.011
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
myristoyl-CoAPubChem0.9977.89
3-methylcrotonyl-CoAPubChem0.9849.635
C05273PubChem0.9975.874
1,5-dihydro-FADPubChem0.9787.566
AR-1A9122PubChem0.9787.566
hexanoyl-CoAPubChem0.9865.677
adenosine triphosphatePubChem0.9507.181
C03221PubChem0.9947.821
2MCPubChem0.9835.608
Co-APubChem0.9767.534
lauroyl-CoAPubChem0.9949.837
formatePubChem0.945.0174
palmitoyl-CoAPubChem0.91005.94
FADH2PubChem0.9787.566
C05275PubChem0.9919.768
octanoyl-CoAPubChem0.9893.73
propionyl-CoAPubChem0.9823.597
protiumPubChem0.92.01576
trans-2-hexadecenoyl-CoAPubChem0.91003.93
flavin adenine dinucleotidePubChem0.9785.55
NSC112207PubChem0.9785.55
methylcrotonyl CoAPubChem0.9849.635
adenosine monophosphatePubChem0.9347.221
C05276PubChem0.9891.714
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
decanoyl-CoAPubChem0.9921.783
butyryl-CoAPubChem0.9837.624
hydroxyl radicalsPubChem0.917.0073
acryloyl-CoAPubChem0.9821.581
trans-2-enoyl-CoAsPubChem0.9821.581
coenzyme APubChem0.9767.534
pyrophosphatePubChem0.9177.975
methacrylyl-CoAPubChem0.9835.608
C05271PubChem0.9863.661
crotonyl-CoAPubChem0.9835.608