Rv0753c

Tuberculist information
Gene namemmsA
Protein functionProbable methylmalonate-semialdehyde dehydrogenase MmsA (methylmalonic acid semialdehyde dehydrogenase) (MMSDH)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)844.421
Molecular mass(da)54453.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 510
	  		  	1    MTTQISHFIDGQRTAGQSTRSADVFDPNTGQIQAKVPMAGKSDIDAAVASAVEAQKGWAA   60
			  	61   WNPQRRARVLMRFIELVNDTIDELAELLSREHGKTLADARGDVQRGIEVIEFCLGIPHLL  120
			  	121  KGEYTEGAGPGIDVYSLRQPLGVVAGITPFNFPAMIPLWKAGPALACGNAFVLKPSERDP  180
			  	181  SVPVRLAELFIEAGLPAGVFQVVHGDKEAVDAILHHPDIKAVGFVGSSDIAQYIYAGAAA  240
			  	241  TGKRAQCFGGAKNHMIVMPDADLDQAVDALIGAGYGSAGERCMAISVAVPVGDQTAERLR  300
			  	301  ARLIERINNLRVGHSLDPKADYGPLVTGAALARVRDYIGQGVAAGAELVVDGRDRASDDL  360
			  	361  TFGLPEGDANLEGGFFIGPTLFDHVAAHMSIYTDEIFGPVLCMVRARDYEEALRLPSEHE  420
			  	421  YGNGVAIFTRDGDAARDFVSRVQVGMVGVNVPIPVPVAYHTFGGWKRSGFGDLNQHGPAA  480
			  	481  IQFYTKVKTVTSRWPSGIKDGAEFVIPTMS

Known structures in the PDB
No Known structures
1 52 103 154 205 256 307 358 409 460 511 Range: 14 to 490  |  Coverage: 93% Aldedh Range: 3 to 496  |  Coverage: 96% 1 Range: 1 to 510  |  Coverage: 99% 1 Range: 248 to 471  |  Coverage: 43% 2
Number of amino acids : 510
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
AldedhPF0017114-490
Mtb Structural Proteome models
Model Number1
Model nameRv0753c
Template1T90    APDBCREDO
Template coverage5_483
Template Identity(%)42.0
Model coverage(%)96.7
Normalized DOPE score-0.957

Structure Models from Chopin
Model Number1
Profilec.82.1.1
Click for model details
zscore56.75
Residue begin1
Residue end510
Model Number2
Profile3.40.309.10
Click for model details
zscore41.61
Residue begin248
Residue end471
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0753cGene nameConfidence Score
Rv0751cmmsB0.996
Rv0751cmmsB0.996
Rv3667acs0.959
Rv3667acs0.959
Rv2589gabT0.94
Rv0231fadE40.921
Rv0231fadE40.921
Rv0131cfadE10.92
Rv0131cfadE10.92
Rv0860fadB0.92
Rv0131cfadE10.92
Rv0860fadB0.92
Rv0860fadB0.92
Rv0154cfadE20.919
Rv0154cfadE20.919
Rv0154cfadE20.919
Rv0770Rv07700.914
Rv2790cltp10.914
Rv0770Rv07700.914
Rv2790cltp10.914
Rv2858caldC0.914
Rv0768aldA0.912
Rv0408pta0.912
Rv0408pta0.912
Rv0408pta0.912
Rv0752cfadE90.911
Rv0752cfadE90.911
Rv0752cfadE90.911
Rv0458Rv04580.909
Rv0147Rv01470.908
Rv0975cfadE130.906
Rv0975cfadE130.906
Rv0975cfadE130.906
Rv0973caccA20.904
Rv0973caccA20.904
Rv0973caccA20.904
Rv0973caccA20.904
Rv3140fadE230.902
Rv3140fadE230.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.956663.425
propionyl-CoAPubChem0.924823.597
methylmalonate semialdehydePubChem0.922102.089
coenzyme APubChem0.917767.534
H(+)PubChem0.9032.01588
bicarbonatePubChem0.90262.0248
deuteriumPubChem0.9022.01588
propionyl-coenzyme APubChem0.9823.597
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
C06002PubChem0.9102.089
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
Co-APubChem0.9767.534
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
carbon dioxidePubChem0.944.0095
n-propionyl-CoAPubChem0.9823.597