Rv3140

Tuberculist information
Gene namefadE23
Protein functionProbable acyl-CoA dehydrogenase FadE23
Functional category(tuberculist)lipid metabolism
Gene location(kb)3506.79
Molecular mass(da)43344.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 401
	  		  	1    MAINLELPRKLQAIIVKTHQGAAEMMRPIARKYDLKEHAYPVELDTLINLFEGAAESFNF   60
			  	61   AGAHSLRDEDEGKDENHNGANMAAVVQTMEASWGDVAMMLSLPYQGLGNAAISAVATDEQ  120
			  	121  LERLGKVWAAMAITEPEFGSDSAAVSTTATLDGDEYVINGEKIFVTAGSRATHIVVWATL  180
			  	181  DKSLGRPAIKSFIVPREHPGVTVERLEHKLGIKGSDTAVIRFDNARIPKGNLLGNPEIEV  240
			  	241  GKGFAGVMETFDNTRPIVAAMAVGIGRAALEEIRSVLTGAGVEISYDKPSHTQSAAAAEF  300
			  	301  LRMEADWEASYLLSLRAAWQADNNIPNSKEASMSKAKAGRMASDVTCKTVELAGTTGYSE  360
			  	361  QSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSSELK

Known structures in the PDB
No Known structures
1 41 81 121 161 201 241 281 321 361 401 Range: 130 to 181  |  Coverage: 12% Acyl-CoA_dh_M Range: 241 to 393  |  Coverage: 37% Acyl-CoA_dh_1 Range: 4 to 397  |  Coverage: 98% 1 Range: 1 to 401  |  Coverage: 99% 1 Range: 239 to 401  |  Coverage: 40% 2 Range: 1 to 240  |  Coverage: 59% 3
Number of amino acids : 401
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_MPF02770130-181
Acyl-CoA_dh_1PF00441241-393
Mtb Structural Proteome models
Model Number1
Model nameRv3140
Template1JQI    APDBCREDO
Template coverage7_387
Template Identity(%)31.0
Model coverage(%)98.0
Normalized DOPE score-0.156

Structure Models from Chopin
Model Number1
Profilea.29.3.1, e.6.1.1 - 1.10.540.10, 1.20.140.10, 2.40.110.10
Click for model details
zscore59.1
Residue begin1
Residue end401
Model Number2
Profilea.29.3.1
Click for model details
zscore34.06
Residue begin239
Residue end401
Model Number3
Profilee.6.1.1
Click for model details
zscore16.27
Residue begin1
Residue end240
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3140Gene nameConfidence Score
Rv3774echA210.963
Rv0243fadA20.949
Rv0243fadA20.949
Rv0675echA50.936
Rv3546fadA50.935
Rv3546fadA50.935
Rv3556cfadA60.933
Rv3556cfadA60.933
Rv1074cfadA30.932
Rv1074cfadA30.932
Rv0914cRv0914c0.93
Rv0914cRv0914c0.93
Rv0859fadA0.925
Rv0859fadA0.925
Rv3139fadE240.92
Rv3139fadE240.92
Rv3139fadE240.92
Rv0860fadB0.919
Rv0860fadB0.919
Rv0860fadB0.919
Rv1323fadA40.914
Rv1323fadA40.914
Rv2724cfadE200.913
Rv2724cfadE200.913
Rv2724cfadE200.913
Rv0408pta0.907
Rv0408pta0.907
Rv0408pta0.907
Rv3667acs0.904
Rv2790cltp10.904
Rv2790cltp10.904
Rv2502caccD10.904
Rv3667acs0.904
Rv3561fadD30.903
Rv1071cechA90.903
Rv3561fadD30.903
Rv1071cechA90.903
Rv0166fadD50.902
Rv0166fadD50.902
Rv0753cmmsA0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
flavin adenine dinucleotidePubChem0.917785.55
octanoyl-CoAPubChem0.907893.73
butyryl-CoAPubChem0.906837.624
CO8PubChem0.904893.73
hexanoyl-CoAPubChem0.903865.677
propionyl-CoAPubChem0.903823.597
coenzyme APubChem0.902767.534
acryloyl-CoAPubChem0.902821.581
trans-2-enoyl-CoAsPubChem0.901821.581
crotonyl-CoAPubChem0.901835.608
adenosine triphosphatePubChem0.9507.181
C05276PubChem0.9891.714
2MCPubChem0.9835.608
methacrylyl-CoAPubChem0.9835.608
lauroyl-CoAPubChem0.9949.837
formatePubChem0.945.0174
NSC112207PubChem0.9785.55
4-cis-decenoyl-CoAPubChem0.9919.768
palmitoyl-CoAPubChem0.91005.94
protiumPubChem0.92.01576
H(+)PubChem0.92.01588
trans-2-decenoyl-coenzyme APubChem0.9919.768
C05271PubChem0.9863.661
decanoyl coenzyme APubChem0.9921.783
methylcrotonyl CoAPubChem0.9849.635
adenosine monophosphatePubChem0.9347.221
C05273PubChem0.9975.874
deuteriumPubChem0.92.01588
FADH2PubChem0.9787.566
decanoyl-CoAPubChem0.9921.783
C03221PubChem0.9947.821
hydroxyl radicalsPubChem0.917.0073
2-trans,4-cis-decadienoyl-CoAPubChem0.9917.752
AR-1A9122PubChem0.9787.566
pyrophosphatePubChem0.9177.975
trans-2-octenoyl-coenzyme APubChem0.9891.714
C05275PubChem0.9919.768
Co-APubChem0.9767.534
myristoyl-CoAPubChem0.9977.89
3-methylcrotonyl-CoAPubChem0.9849.635
trans-2-hexadecenoyl-CoAPubChem0.91003.93
1,5-dihydro-FADPubChem0.9787.566