Rv3556c

Tuberculist information
Gene namefadA6
Protein functionProbable acetyl-CoA acetyltransferase FadA6 (acetoacetyl-CoA thiolase)
Functional category(tuberculist)lipid metabolism
Gene location(kb)3995.8
Molecular mass(da)40902.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 386
	  		  	1    MTEAYVIDAVRTAVGKRGGALAGIHPVDLGALAWRGLLDRTDIDPAAVDDVIAGCVDAIG   60
			  	61   GQAGNIARLSWLAAGYPEEVPGVTVDRQCGSSQQAISFGAQAIMSGTADVIVAGGVQNMS  120
			  	121  QIPISSAMTVGEQFGFTSPTNESKQWLHRYGDQEISQFRGSELIAEKWNLSREEMERYSL  180
			  	181  TSHERAFAAIRAGHFENEIITVETESGPFRVDEGPRESSLEKMAGLQPLVEGGRLTAAMA  240
			  	241  SQISDGASAVLLASERAVKDHGLRPRARIHHISARAADPVFMLTGPIPATRYALDKTGLA  300
			  	301  IDDIDTVEINEAFAPVVMAWLKEIKADPAKVNPNGGAIALGHPLGATGAKLFTTMLGELE  360
			  	361  RIGGRYGLQTMCEGGGTANVTIIERL

Known structures in the PDB
No Known structures
1 39 77 115 153 191 229 267 305 343 381 Range: 1 to 256  |  Coverage: 66% Thiolase_N Range: 263 to 385  |  Coverage: 31% Thiolase_C Range: 3 to 384  |  Coverage: 98% 1 Range: 1 to 256  |  Coverage: 66% 1
Number of amino acids : 386
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Thiolase_NPF001081-256
Thiolase_CPF02803263-385
Mtb Structural Proteome models
Model Number1
Model nameRv3556c
Template1ULQ    APDBCREDO
Template coverage3_398
Template Identity(%)41.9
Model coverage(%)98.7
Normalized DOPE score-0.591

Structure Models from Chopin
Model Number1
Profilec.95.1.1
Click for model details
zscore39.74
Residue begin1
Residue end256
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3556cGene nameConfidence Score
Rv0468fadB20.986
Rv0468fadB20.986
Rv2504cscoA0.985
Rv2503cscoB0.974
Rv0860fadB0.973
Rv0860fadB0.973
Rv0860fadB0.973
Rv1715fadB30.954
Rv1715fadB30.954
Rv3667acs0.953
Rv3667acs0.953
Rv0896gltA20.948
Rv0975cfadE130.946
Rv0975cfadE130.946
Rv0975cfadE130.946
Rv0408pta0.945
Rv0408pta0.945
Rv0408pta0.945
Rv3535chsaG0.939
Rv3535chsaG0.939
Rv1131prpC0.936
Rv3140fadE230.933
Rv3140fadE230.933
Rv2790cltp10.927
Rv2790cltp10.927
Rv0154cfadE20.921
Rv0154cfadE20.921
Rv0154cfadE20.921
Rv0131cfadE10.918
Rv0131cfadE10.918
Rv0131cfadE10.918
Rv0889ccitA0.915
Rv0904caccD30.914
Rv2495cbkdC0.901
Rv2495cbkdC0.901
Rv2495cbkdC0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetoacetyl-CoAPubChem0.962851.607
acetyl-CoAPubChem0.942809.571
coenzyme APubChem0.929767.534
3-hydroxybutyryl-CoAPubChem0.919853.623
Co-APubChem0.914767.534
butyryl-CoAPubChem0.914837.624
3-ketohexanoyl-CoAPubChem0.903879.661
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
acetoacetyl-S-CoAPubChem0.9851.607
carbon dioxidePubChem0.944.0095
H(+)PubChem0.92.01588
NAD+PubChem0.9663.425
pyruvic acidPubChem0.988.0621
acetyl coenzyme-APubChem0.9809.571
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576