Rv0904c

Tuberculist information
Gene nameaccD3
Protein functionPutative acetyl-coenzyme A carboxylase carboxyl transferase (subunit beta) AccD3 (accase beta chain)
Functional category(tuberculist)lipid metabolism
Gene location(kb)1006.69
Molecular mass(da)51740.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 495
	  		  	1    VSRITTDQLRHAVLDRGSFVSWDSEPLAVPVADSYARELAAARAATGADESVQTGEGRVF   60
			  	61   GRRVAVVACEFDFLGGSIGVAAAERITAAVERATAERLPLLASPSSGGTRMQEGTVAFLQ  120
			  	121  MVKIAAAIQLHNQARLPYLVYLRHPTTGGVFASWGSLGHLTVAEPGALIGFLGPRVYELL  180
			  	181  YGDPFPSGVQTAENLRRHGIIDGVVALDRLRPMLDRALTVLIDAPEPLPAPQTPAPVPDV  240
			  	241  PTWDSVVASRRPDRPGVRQLLRHGATDRVLLSGTDQGEAATTLLALARFGGQPTVVLGQQ  300
			  	301  RAVGGGGSTVGPAALREARRGMALAAELCLPLVLVIDAAGPALSAAAEQGGLAGQIAHCL  360
			  	361  AELVTLDTPTVSILLGQGSGGPALAMLPADRVLAALHGWLAPLPPEGASAIVFRDTAHAA  420
			  	421  ELAAAQGIRSADLLKSGIVDTIVPEYPDAADEPIEFALRLSNAIAAEVHALRKIPAPERL  480
			  	481  ATRLQRYRRIGLPRD

Known structures in the PDB
No Known structures
1 50 99 148 197 246 295 344 393 442 491 Range: 12 to 482  |  Coverage: 94% Carboxyl_trans Range: 2 to 477  |  Coverage: 95% 1 Range: 20 to 495  |  Coverage: 95% 1
Number of amino acids : 495
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Carboxyl_transPF0103912-482
Mtb Structural Proteome models
Model Number1
Model nameRv0904c
Template1ON3    APDBCREDO
Template coverage43_517
Template Identity(%)21.7
Model coverage(%)96.0
Normalized DOPE score0.592

Structure Models from Chopin
Model Number1
Profilec.14.1.4
Click for model details
zscore16.48
Residue begin20
Residue end495
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0904cGene nameConfidence Score
Rv3285accA30.997
Rv3285accA30.997
Rv3285accA30.997
Rv3285accA30.997
Rv2501caccA10.996
Rv2501caccA10.996
Rv2501caccA10.996
Rv2501caccA10.996
Rv2243fabD0.995
Rv2244acpM0.982
Rv0533cfabH0.964
Rv0533cfabH0.964
Rv0533cfabH0.964
Rv2245kasA0.95
Rv2245kasA0.95
Rv0408pta0.944
Rv0408pta0.944
Rv0408pta0.944
Rv2524cfas0.939
Rv2524cfas0.939
Rv2524cfas0.939
Rv2524cfas0.939
Rv2524cfas0.939
Rv2524cfas0.939
Rv2524cfas0.939
Rv3667acs0.934
Rv3667acs0.934
Rv1323fadA40.924
Rv1323fadA40.924
Rv0649fabD20.922
Rv2447cfolC0.92
Rv2447cfolC0.92
Rv1837cglcB0.92
Rv1074cfadA30.917
Rv1074cfadA30.917
Rv3556cfadA60.914
Rv3556cfadA60.914
Rv0859fadA0.913
Rv0859fadA0.913
Rv3546fadA50.91
Rv3546fadA50.91
Rv0243fadA20.906
Rv0243fadA20.906
Rv2495cbkdC0.904
Rv2495cbkdC0.904
Rv2495cbkdC0.904
Rv3710leuA0.903
Rv3710leuA0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
malonyl-CoAPubChem0.981853.58
acetyl-CoAPubChem0.976809.571
bicarbonatePubChem0.92162.0248
phosphatePubChem0.90196.9872
protiumPubChem0.92.01576
adenosine diphosphatePubChem0.9427.201
coenzyme APubChem0.9767.534
H(+)PubChem0.92.01588
deuteriumPubChem0.92.01588
Co-APubChem0.9767.534
adenosine triphosphatePubChem0.9507.181
acetyl coenzyme-APubChem0.9809.571
malonylcoenzyme APubChem0.9853.58