Rv2501c

Tuberculist information
Gene nameaccA1
Protein functionProbable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA1: biotin carboxylase + biotin carboxyl carrier protein (BCCP)
Functional category(tuberculist)lipid metabolism
Gene location(kb)2814.92
Molecular mass(da)70592.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 654
	  		  	1    MFDTVLVANRGEIAVRVIRTLRRLGIRSVAVYSDPDVDARHVLEADAAVRLGPAPARESY   60
			  	61   LDIGKVLDAAARTGAQAIHPGYGFLAENADFAAACERARVVFLGPPARAIEVMGDKIAAK  120
			  	121  NAVAAFDVPVVPGVARAGLTDDALVTAAAEVGYPVLIKPSAGGGGKGMRLVQDPARLPEA  180
			  	181  LVSARREAMSSFGDDTLFLERFVLRPRHIEVQVLADAHGNVVHLGERECSLQRRHQKVIE  240
			  	241  EAPSPLLDPQTRERIGVAACNTARCVDYVGAGTVEFIVSAQRPDEFFFMEMNTRLQVEHP  300
			  	301  VTEAITGLDLVEWQLRVGAGEKLGFAQNDIELRGHAIEARVYAEDPAREFLPTGGRVLAV  360
			  	361  FEPAGPGVRVDSSLLGGTVVGSDYDPLLTKVIAHGADREEALDRLDQALARTAVLGVQTN  420
			  	421  VEFLRFLLADERVRVGDLDTAVLDERSADFTARPAPDDVLAAGGLYRQWALARRAQGDLW  480
			  	481  AAPSGWRGGGHMAPVRTAMRTPLRSETVSVWGPPESAQVQVGDGEIDCASVQVTREQMSV  540
			  	541  TISGLRRDYRWAEADRHLWIADERGTWHLREAEEHKIHRAVGARPAEVVSPMPGSVIAVQ  600
			  	601  VESGSQISAGDVVVVVEAMKMEHSLEAPVSGRVQVLVSVGDQVKVEQVLARIKD

Known structures in the PDB
No Known structures
1 66 131 196 261 326 391 456 521 586 651 Range: 1 to 110  |  Coverage: 16% CPSase_L_chain Range: 115 to 326  |  Coverage: 32% CPSase_L_D2 Range: 338 to 444  |  Coverage: 16% Biotin_carb_C Range: 586 to 652  |  Coverage: 10% Biotin_lipoyl Range: 588 to 652  |  Coverage: 9% 1 Range: 1 to 454  |  Coverage: 69% 2 Range: 1 to 447  |  Coverage: 68% 1 Range: 115 to 326  |  Coverage: 32% 2 Range: 333 to 447  |  Coverage: 17% 3 Range: 572 to 654  |  Coverage: 12% 4 Range: 1 to 654  |  Coverage: 99% 5 Range: 114 to 396  |  Coverage: 43% 6 Range: 1 to 320  |  Coverage: 48% 7 Range: 115 to 223  |  Coverage: 16% 8 Range: 1 to 110  |  Coverage: 16% 9
Number of amino acids : 654
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CPSase_L_chainPF002891-110
CPSase_L_D2PF02786115-326
Biotin_carb_CPF02785338-444
Biotin_lipoylPF00364586-652
Mtb Structural Proteome models
Model Number1
Model nameRv2501c.2
Template2B8F    APDBCREDO
Template coverage3_68
Template Identity(%)38.5
Model coverage(%)9.8
Normalized DOPE score-0.596

Model Number2
Model nameRv2501c
Template1ULZ    APDBCREDO
Template coverage1_451
Template Identity(%)43.9
Model coverage(%)69.2
Normalized DOPE score-0.435

Structure Models from Chopin
Model Number1
Profileb.84.2.1, c.30.1.1, d.142.1.2 - 3.30.1490.20, 3.30.470.20
Click for model details
zscore60.78
Residue begin1
Residue end447
Model Number2
Profiled.142.1.2
Click for model details
zscore22.46
Residue begin115
Residue end326
Model Number3
Profileb.84.2.1
Click for model details
zscore18.32
Residue begin333
Residue end447
Model Number4
Profileb.84.1.1 - 2.40.50.100
Click for model details
zscore16.07
Residue begin572
Residue end654
Model Number5
Profilea.92.1.1, c.24.1.1, c.30.1.1, d.142.1.2 - 1.10.1030.10, 3.30.1490.20, 3.30.470.20, 3.40.50.1380, 3.40.50.20
Click for model details
zscore15.58
Residue begin1
Residue end654
Model Number6
Profiled.142.1.2
Click for model details
zscore15.05
Residue begin114
Residue end396
Model Number7
Profilec.30.1.5, d.142.1.3 - 3.30.1490.20, 3.30.470.20, 3.40.50.20
Click for model details
zscore12.39
Residue begin1
Residue end320
Model Number8
Profile3.30.1490.20
Click for model details
zscore10.4
Residue begin115
Residue end223
Model Number9
Profilec.30.1.1
Click for model details
zscore7.41
Residue begin1
Residue end110
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2501cGene nameConfidence Score
Rv2502caccD10.999
Rv0904caccD30.996
Rv3279cbirA0.971
Rv3279cbirA0.971
Rv3280accD50.962
Rv0533cfabH0.932
Rv0533cfabH0.932
Rv0533cfabH0.932
Rv0973caccA20.921
Rv0973caccA20.921
Rv0973caccA20.921
Rv0973caccA20.921
Rv3799caccD40.918
Rv2504cscoA0.903
Potential ligand/drug binding sites
Protein ModelPocket NumberDrug Binding Site PMIN ScorePvalue PMINPMAX ScorePvalue PMAX
Rv2501c.213ret_SAL_B_201PDBCREDO0.6190.1570.6190.001
Rv2501c.213ret_SAL_A_201PDBCREDO0.6160.1610.6160.002
Rv2501c.213hgx_SAL_B_104PDBCREDO0.6040.1750.6040.002
Rv2501c.213hgx_SAL_A_102PDBCREDO0.5900.1910.5900.003
Rv2501c.213rem_SAL_B_301PDBCREDO0.6530.1210.5580.004
Rv2501c.213rem_SAL_A_301PDBCREDO0.6400.1350.5460.005
Rv2501c.213ug2_IRE_A_1PDBCREDO0.6700.1060.5440.006
Rv2501c.213rf4_FUN_B_202PDBCREDO0.6040.1750.5150.009
Rv2501c.213rf4_FUN_A_201PDBCREDO0.6010.1780.5130.009
Rv2501c.213rf4_FUN_C_203PDBCREDO0.5990.1800.5120.009
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
propionyl-CoAPubChem0.974823.597
bicarbonatePubChem0.95662.0248
methylmalonyl-CoAPubChem0.945867.607
adenosine diphosphatePubChem0.94427.201
phosphatePubChem0.92796.9872
carbon dioxidePubChem0.92744.0095
adenosine triphosphatePubChem0.927507.181
(2S)-methylmalonyl-CoAPubChem0.913867.607
coenzyme APubChem0.911767.534
methylmalonyl-coenzyme APubChem0.909867.607
methyl-malonyl-CoAPubChem0.906867.607
L-methylmalonyl-CoAPubChem0.905867.607
methyl-malonyl-coenzyme APubChem0.904862.567
deuteriumPubChem0.9012.01588
protiumPubChem0.92.01576
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
H(+)PubChem0.92.01588
CHEBI:15466PubChem0.9867.607
n-propionyl-CoAPubChem0.9823.597
alpha-ketobutyratePubChem0.9102.089
NAD+PubChem0.9663.425
Co-APubChem0.9767.534
acetyl-CoAPubChem0.778809.571
malonyl-CoAPubChem0.704853.58