Rv0859

Tuberculist information
Gene namefadA
Protein functionPossible acyl-CoA thiolase FadA
Functional category(tuberculist)lipid metabolism
Gene location(kb)955.077
Molecular mass(da)42414.5
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 403
	  		  	1    MSEEAFIYEAIRTPRGKQKNGSLHEVKPLSLVVGLIDELRKRHPDLDENLISDVILGCVS   60
			  	61   PVGDQGGDIARAAVLASGMPVTSGGVQLNRFCASGLEAVNTAAQKVRSGWDDLVLAGGVE  120
			  	121  SMSRVPMGSDGGAMGLDPATNYDVMFVPQSIGADLIATIEGFSREDVDAYALRSQQKAAE  180
			  	181  AWSGGYFAKSVVPVRDQNGLLILDHDEHMRPDTTKEGLAKLKPAFEGLAALGGFDDVALQ  240
			  	241  KYHWVEKINHVHTGGNSSGIVDGAALVMIGSAAAGKLQGLTPRARIVATATSGADPVIML  300
			  	301  TGPTPATRKVLDRAGLTVDDIDLFELNEAFASVVLKFQKDLNIPDEKLNVNGGAIAMGHP  360
			  	361  LGATGAMILGTMVDELERRNARRALITLCIGGGMGVATIIERV

Known structures in the PDB
PDB ID4B3H
Total residue count2278
Number of chains4
MethodX-RAY
Resolution2.3
PDB ID4B3I
Total residue count2278
Number of chains4
MethodX-RAY
Resolution2.63
PDB ID4B3J
Total residue count2278
Number of chains4
MethodX-RAY
Resolution2.5
1 41 81 121 161 201 241 281 321 361 401 Range: 2 to 230  |  Coverage: 56% Thiolase_N Range: 280 to 402  |  Coverage: 30% Thiolase_C Range: 3 to 403  |  Coverage: 99% 1 Range: 2 to 230  |  Coverage: 56% 1
Number of amino acids : 403
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Thiolase_NPF001082-230
Thiolase_CPF02803280-402
Mtb Structural Proteome models
Model Number1
Model nameRv0859
Template1WDK    CPDBCREDO
Template coverage6_391
Template Identity(%)40.2
Model coverage(%)99.3
Normalized DOPE score-0.146

Structure Models from Chopin
Model Number1
Profilec.95.1.1
Click for model details
zscore42.3
Residue begin2
Residue end230
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0859Gene nameConfidence Score
Rv0860fadB0.999
Rv0860fadB0.999
Rv0860fadB0.999
Rv2504cscoA0.985
Rv2503cscoB0.979
Rv0468fadB20.973
Rv0468fadB20.973
Rv1715fadB30.952
Rv1715fadB30.952
Rv0896gltA20.951
Rv0975cfadE130.95
Rv0975cfadE130.95
Rv0975cfadE130.95
Rv3667acs0.949
Rv3667acs0.949
Rv0408pta0.942
Rv0408pta0.942
Rv0408pta0.942
Rv3535chsaG0.934
Rv3535chsaG0.934
Rv2790cltp10.926
Rv2790cltp10.926
Rv3140fadE230.925
Rv3140fadE230.925
Rv0154cfadE20.924
Rv0154cfadE20.924
Rv0154cfadE20.924
Rv1131prpC0.92
Rv0131cfadE10.916
Rv0131cfadE10.916
Rv0131cfadE10.916
Rv0889ccitA0.914
Rv0904caccD30.913
Rv0231fadE40.911
Rv0231fadE40.911
Rv2495cbkdC0.901
Rv2495cbkdC0.901
Rv2495cbkdC0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetoacetyl-CoAPubChem0.955851.607
acetyl-CoAPubChem0.939809.571
butyryl-CoAPubChem0.914837.624
3-ketohexanoyl-CoAPubChem0.904879.661