Rv0468

Tuberculist information
Gene namefadB2
Protein function3-hydroxybutyryl-CoA dehydrogenase FadB2 (beta-hydroxybutyryl-CoA dehydrogenase) (BHBD)
Functional category(tuberculist)lipid metabolism
Gene location(kb)558.895
Molecular mass(da)30696.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 286
	  		  	1    VSDAIQRVGVVGAGQMGSGIAEVSARAGVEVTVFEPAEALITAGRNRIVKSLERAVSAGK   60
			  	61   VTERERDRALGLLTFTTDLNDLSDRQLVIEAVVEDEAVKSEIFAELDRVVTDPDAVLASN  120
			  	121  TSSIPIMKVAAATKQPQRVLGLHFFNPVPVLPLVELVRTLVTDEAAAARTEEFASTVLGK  180
			  	181  QVVRCSDRSGFVVNALLVPYLLSAIRMVEAGFATVEDVDKAVVAGLSHPMGPLRLSDLVG  240
			  	241  LDTLKLIADKMFEEFKEPHYGPPPLLLRMVEAGQLGKKSGRGFYTY

Known structures in the PDB
No Known structures
1 29 57 85 113 141 169 197 225 253 281 Range: 7 to 188  |  Coverage: 63% 3HCDH_N Range: 190 to 286  |  Coverage: 33% 3HCDH Range: 2 to 286  |  Coverage: 99% 1 Range: 2 to 286  |  Coverage: 99% 1 Range: 185 to 286  |  Coverage: 35% 2 Range: 1 to 102  |  Coverage: 35% 3
Number of amino acids : 286
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
3HCDH_NPF027377-188
3HCDHPF00725190-286
Mtb Structural Proteome models
Model Number1
Model nameRv0468
Template3HDH    APDBCREDO
Template coverage12_301
Template Identity(%)40.0
Model coverage(%)99.3
Normalized DOPE score-0.533

Structure Models from Chopin
Model Number1
Profilea.100.1.3, c.2.1.6 - 1.10.1040.10, 3.40.50.720
Click for model details
zscore54.59
Residue begin2
Residue end286
Model Number2
Profilea.100.1.3
Click for model details
zscore10.39
Residue begin185
Residue end286
Model Number3
Profilec.5.1.1
Click for model details
zscore4.68
Residue begin1
Residue end102
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0468Gene nameConfidence Score
Rv1070cechA80.996
Rv3556cfadA60.986
Rv3556cfadA60.986
Rv1323fadA40.984
Rv1323fadA40.984
Rv1074cfadA30.978
Rv1074cfadA30.978
Rv3039cechA170.975
Rv0859fadA0.973
Rv0859fadA0.973
Rv0905echA60.971
Rv3546fadA50.971
Rv3546fadA50.971
Rv1472echA120.97
Rv3774echA210.968
Rv0222echA10.966
Rv1142cechA100.963
Rv3516echA190.963
Rv1071cechA90.962
Rv1071cechA90.962
Rv2831echA160.96
Rv0971cechA70.957
Rv3373echA180.956
Rv0675echA50.955
Rv0243fadA20.948
Rv0243fadA20.948
Rv1141cechA110.946
Rv2503cscoB0.946
Rv0860fadB0.946
Rv0860fadB0.946
Rv0860fadB0.946
Rv2486echA140.944
Rv0467icl10.941
Rv0632cechA30.94
Rv3550echA200.937
Rv2504cscoA0.936
Rv2679echA150.928
Rv0914cRv0914c0.922
Rv0914cRv0914c0.922
Rv3523ltp30.919
Rv0673echA40.917
Rv3028cfixB0.916
Rv3028cfixB0.916
Rv1935cechA130.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetoacetyl-CoAPubChem0.989851.607
3-hydroxybutyryl-CoAPubChem0.985853.623
NAD+PubChem0.982663.425
acetoacetyl-coenzyme APubChem0.958851.607
reduced nicotinamide adenine dinucleotidePubChem0.946665.441
c0030PubChem0.945853.623
coenzyme APubChem0.941767.534
3-hydroxydecanoyl-CoAPubChem0.932937.783
acetyl-CoAPubChem0.925809.571
3-ketohexanoyl-CoAPubChem0.911879.661
crotonyl-CoAPubChem0.907835.608
deuteriumPubChem0.9012.01588
H(+)PubChem0.9012.01588
C01144PubChem0.9853.623
3-oxooctanoyl-CoAPubChem0.9907.714
CHEBI:27668PubChem0.9965.836
protiumPubChem0.92.01576
acetyl coenzyme-APubChem0.9809.571
C05262PubChem0.9965.836
3-oxodecanoyl-coenzyme APubChem0.9935.767
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
3-hydroxyhexanoyl-coenzyme APubChem0.9881.677
C05266PubChem0.9909.73
3-oxododecanoyl-coenzyme APubChem0.9963.82
3-Ketohexanoyl-coenzyme APubChem0.9879.661
C05268PubChem0.9881.677
CHEBI:28632PubChem0.9909.73
acetoacetyl-S-CoAPubChem0.9851.607
hydroxyl radicalsPubChem0.917.0073
C05263PubChem0.9963.82
3-Hydroxydecanoyl-coenzyme APubChem0.9937.783
Co-APubChem0.9767.534
C05265PubChem0.9935.767
3-oxooctanoyl-coenzyme APubChem0.9907.714