Rv0914c

Tuberculist information
Gene nameRv0914c
Protein functionPossible lipid carrier protein or keto acyl-CoA thiolase
Functional category(tuberculist)lipid metabolism
Gene location(kb)1018.73
Molecular mass(da)43874.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 412
	  		  	1    MDDGVWILGGYQSDFARNLSKENRDFADLTREVVDGTLTAAKVDAADLAAAGVVHVANAF   60
			  	61   GEMFARQGHLGAMPATVCDDLWDTPATRHEAACASGSVATLAAMADLRSGAYRVALVVGL  120
			  	121  ELEKTVPGDTAAEHLSAAAWTGHEGAEARYLWPSMFAQVADEYDRRYGLDDTHLRAIAQL  180
			  	181  NFANARRNPNAQTRGWTIPDPITDDDATNPLTEGRLRRFDCSQMTDGGAGLVLVSDAYLR  240
			  	241  DHRDARPIGRIDGWGHRTVGLGLRQKLDRVAQGDSAPYLLPHVRATVLDALRRARVTLDD  300
			  	301  LDGIEVHDCFTPSEYLAIDHIGLTGPGESWKAIENGEIEIGGRLPINPSGGLIGGGHPVG  360
			  	361  ASGVRMLLDAAKQVSGIAGDYQVENAEAFGTLNFGGSTATTVSFVVSTTRGS

Known structures in the PDB
No Known structures
1 42 83 124 165 206 247 288 329 370 411 Range: 15 to 149  |  Coverage: 32% Thiolase_N Range: 266 to 399  |  Coverage: 32% Thiolase_C Range: 2 to 409  |  Coverage: 98% 1 Range: 15 to 149  |  Coverage: 32% 1 Range: 1 to 412  |  Coverage: 99% 2
Number of amino acids : 412
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Thiolase_NPF0010815-149
Thiolase_CPF02803266-399
Mtb Structural Proteome models
Model Number1
Model nameRv0914c
Template1WL4    APDBCREDO
Template coverage5_397
Template Identity(%)18.1
Model coverage(%)98.8
Normalized DOPE score0.422

Structure Models from Chopin
Model Number1
Profilec.95.1.1
Click for model details
zscore8.92
Residue begin15
Residue end149
Model Number2
Profilec.95.1.1
Click for model details
zscore8.42
Residue begin1
Residue end412
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0914cGene nameConfidence Score
Rv0913cRv0913c0.968
Rv2504cscoA0.947
Rv0975cfadE130.935
Rv0975cfadE130.935
Rv0975cfadE130.935
Rv3140fadE230.93
Rv3140fadE230.93
Rv3535chsaG0.93
Rv2503cscoB0.93
Rv3535chsaG0.93
Rv3667acs0.922
Rv0468fadB20.922
Rv3667acs0.922
Rv0468fadB20.922
Rv0408pta0.921
Rv0408pta0.921
Rv0408pta0.921
Rv2790cltp10.92
Rv2790cltp10.92
Rv1715fadB30.919
Rv0896gltA20.919
Rv1715fadB30.919
Rv0131cfadE10.914
Rv0131cfadE10.914
Rv0131cfadE10.914
Rv1131prpC0.91
Rv0889ccitA0.907
Rv0154cfadE20.904
Rv0154cfadE20.904
Rv0154cfadE20.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetoacetyl-CoAPubChem0.909851.607
acetyl-CoAPubChem0.9809.571
3-ketohexanoyl-CoAPubChem0.9879.661
butyryl-CoAPubChem0.9837.624