Rv0154c

Tuberculist information
Gene namefadE2
Protein functionProbable acyl-CoA dehydrogenase FadE2
Functional category(tuberculist)lipid metabolism
Gene location(kb)181.987
Molecular mass(da)44343.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 403
	  		  	1    MSAKAIDYRTRLSDFMTEHVFGAEADYDDYRRAAGPADHTAPPIIEELKTKAKDRGLWNL   60
			  	61   FLSAESGLTNLEYAPLAEMTGWSMEIAPEALNCAAPDTGNMEILHMFGTEQQRAQWLRPL  120
			  	121  LDGKIRSAFSMTEPAVASSDARNIETTISRDGADYVINGRKWWTSGAADPRCKILIVMGR  180
			  	181  TNPDAAAHQQQSMVLVPIDTPGVTIVRSTPVFGWQDRHGHCEIDYHNVRVPATNLLGEEG  240
			  	241  SGFAIAQARLGPGRIHHCMRALGAAERALALMVNRVRNRVAFGRPLAEQGVVQQAIAQSR  300
			  	301  NEIDQARLLCEKAAWTIDQHGNKEARHLVAMIKAVAPRVACDVIDRAIQVHGAAGVSDDT  360
			  	361  PLARLYGWHRAMRIFDGPDEVHLRSIARAELSREKSTFAAAVT

Known structures in the PDB
No Known structures
1 41 81 121 161 201 241 281 321 361 401 Range: 2 to 124  |  Coverage: 30% Acyl-CoA_dh_N Range: 128 to 182  |  Coverage: 13% Acyl-CoA_dh_M Range: 240 to 391  |  Coverage: 37% Acyl-CoA_dh_1 Range: 1 to 392  |  Coverage: 97% 1 Range: 1 to 397  |  Coverage: 98% 1 Range: 238 to 403  |  Coverage: 40% 2 Range: 1 to 243  |  Coverage: 60% 3 Range: 2 to 124  |  Coverage: 30% 4 Range: 1 to 362  |  Coverage: 89% 5
Number of amino acids : 403
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Acyl-CoA_dh_NPF027712-124
Acyl-CoA_dh_MPF02770128-182
Acyl-CoA_dh_1PF00441240-391
Mtb Structural Proteome models
Model Number1
Model nameRv0154c
Template1BUC    APDBCREDO
Template coverage5_383
Template Identity(%)28.5
Model coverage(%)97.0
Normalized DOPE score-0.504

Structure Models from Chopin
Model Number1
Profile1.10.540.10, 2.40.110.10
Click for model details
zscore50.37
Residue begin1
Residue end397
Model Number2
Profilea.29.3.1
Click for model details
zscore33.4
Residue begin238
Residue end403
Model Number3
Profilee.6.1.1
Click for model details
zscore16.13
Residue begin1
Residue end243
Model Number4
Profile1.10.540.10
Click for model details
zscore10.07
Residue begin2
Residue end124
Model Number5
Profilee.6.1.2
Click for model details
zscore8.39
Residue begin1
Residue end362
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0154cGene nameConfidence Score
Rv3761cfadE360.969
Rv2790cltp10.933
Rv2790cltp10.933
Rv1071cechA90.932
Rv0456cechA20.932
Rv1071cechA90.932
Rv2679echA150.931
Rv0675echA50.93
Rv1935cechA130.93
Rv1135ARv1135A0.93
Rv0673echA40.93
Rv2831echA160.928
Rv1141cechA110.928
Rv0860fadB0.924
Rv0859fadA0.924
Rv0859fadA0.924
Rv0860fadB0.924
Rv0860fadB0.924
Rv3550echA200.923
Rv1074cfadA30.923
Rv1074cfadA30.923
Rv0632cechA30.922
Rv1323fadA40.921
Rv3556cfadA60.921
Rv3556cfadA60.921
Rv1142cechA100.921
Rv1323fadA40.921
Rv0222echA10.92
Rv0753cmmsA0.919
Rv0971cechA70.919
Rv3546fadA50.918
Rv3546fadA50.918
Rv0243fadA20.916
Rv0243fadA20.916
Rv3516echA190.915
Rv1070cechA80.91
Rv3667acs0.908
Rv2502caccD10.908
Rv3667acs0.908
Rv3774echA210.907
Rv0408pta0.907
Rv0408pta0.907
Rv0408pta0.907
Rv2187fadD150.905
Rv0400cfadE70.904
Rv0914cRv0914c0.904
Rv0914cRv0914c0.904
Rv0400cfadE70.904
Rv0400cfadE70.904
Rv3280accD50.903
Rv1867Rv18670.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acryloyl-CoAPubChem0.902821.581
methacrylyl-CoAPubChem0.901835.608
myristoyl-CoAPubChem0.9977.89
C05273PubChem0.9975.874
3-methylcrotonyl-CoAPubChem0.9849.635
hexanoyl-CoAPubChem0.9865.677
C03221PubChem0.9947.821
octanoyl-CoAPubChem0.9893.73
lauroyl-CoAPubChem0.9949.837
2MCPubChem0.9835.608
C05275PubChem0.9919.768
propionyl-CoAPubChem0.9823.597
trans-2-hexadecenoyl-CoAPubChem0.91003.93
methylcrotonyl CoAPubChem0.9849.635
C05276PubChem0.9891.714
butyryl-CoAPubChem0.9837.624
decanoyl-CoAPubChem0.9921.783
crotonyl-CoAPubChem0.9835.608
trans-2-enoyl-CoAsPubChem0.9821.581
palmitoyl-CoAPubChem0.91005.94
C05271PubChem0.9863.661