Rv1074c

Tuberculist information
Gene namefadA3
Protein functionProbable beta-ketoacyl CoA thiolase FadA3
Functional category(tuberculist)lipid metabolism
Gene location(kb)1198.16
Molecular mass(da)42655.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 405
	  		  	1    MPEAVIVSTARSPIGRAMKGSLVGMRPDDLAVQMVRAALDKVPALNPHQIDDLMMGCGLP   60
			  	61   GGESGFNIARVVAVALGYDFLPGTTVNRYCSSSLQTTRMAFHAIKAGEGDAFISAGVETV  120
			  	121  SRFAKGNSDSWPDTKNPLFDGAQERSAAAAAGADEWHDPRTDQKLPDIYIAMGQTAENVA  180
			  	181  IMTGISREEQDRWGVRSQNRAEEAIKNGFFEREITPVTLPDGTTVSTDDGPRPGTTYEKV  240
			  	241  SELKPAFRPNGTVTAGNACPLNDGAAAVVITSDTKAKELGLTPLARIVSTGVSGLSPEIM  300
			  	301  GLGPIEASKKALERAGMAITDIDLVEINEAFAVQVLGSARELGIDEDKLNISGGAIALGH  360
			  	361  PFGMTGARITTTLLNNLQTYDKTFGLETMCVGGGQGMAMVIERLA

Known structures in the PDB
No Known structures
1 41 81 121 161 201 241 281 321 361 401 Range: 1 to 274  |  Coverage: 67% Thiolase_N Range: 281 to 403  |  Coverage: 30% Thiolase_C Range: 3 to 402  |  Coverage: 98% 1 Range: 1 to 279  |  Coverage: 68% 1
Number of amino acids : 405
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Thiolase_NPF001081-274
Thiolase_CPF02803281-403
Mtb Structural Proteome models
Model Number1
Model nameRv1074c
Template1ULQ    APDBCREDO
Template coverage3_398
Template Identity(%)42.9
Model coverage(%)98.5
Normalized DOPE score-0.444

Structure Models from Chopin
Model Number1
Profilec.95.1.1
Click for model details
zscore43.06
Residue begin1
Residue end279
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1074cGene nameConfidence Score
Rv2504cscoA0.987
Rv0860fadB0.978
Rv0860fadB0.978
Rv0468fadB20.978
Rv0468fadB20.978
Rv0860fadB0.978
Rv2503cscoB0.977
Rv1715fadB30.956
Rv3667acs0.956
Rv1715fadB30.956
Rv3667acs0.956
Rv0896gltA20.952
Rv0408pta0.95
Rv0408pta0.95
Rv0408pta0.95
Rv0975cfadE130.948
Rv0975cfadE130.948
Rv0975cfadE130.948
Rv3535chsaG0.945
Rv3535chsaG0.945
Rv3140fadE230.932
Rv3140fadE230.932
Rv2790cltp10.93
Rv2790cltp10.93
Rv0154cfadE20.923
Rv0154cfadE20.923
Rv0154cfadE20.923
Rv1131prpC0.922
Rv0131cfadE10.919
Rv0131cfadE10.919
Rv0131cfadE10.919
Rv0904caccD30.917
Rv0889ccitA0.916
Rv2495cbkdC0.904
Rv2495cbkdC0.904
Rv2495cbkdC0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
acetoacetyl-CoAPubChem0.965851.607
acetyl-CoAPubChem0.947809.571
coenzyme APubChem0.932767.534
propionyl-CoAPubChem0.919823.597
butyryl-CoAPubChem0.917837.624
Co-APubChem0.914767.534
3-ketohexanoyl-CoAPubChem0.905879.661
2-methylacetoacetyl-coenzyme APubChem0.905865.634
NAD+PubChem0.903663.425
2-methylacetoacetyl-CoAPubChem0.902865.634
deuteriumPubChem0.9012.01588
H(+)PubChem0.92.01588
C05989PubChem0.9837.581
n-propionyl-CoAPubChem0.9823.597
C04405PubChem0.9867.65
CHEBI:15489PubChem0.9837.581
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
acetyl coenzyme-APubChem0.9809.571
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
protiumPubChem0.92.01576
2-methyl-3-hydroxybutyryl-CoAPubChem0.9867.65