Rv0889c

Tuberculist information
Gene namecitA
Protein functionProbable citrate synthase II CitA
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)988.74
Molecular mass(da)40146.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 373
	  		  	1    MTVVPENFVPGLDGVVAFTTEIAEPDKDGGALRYRGVDIEDLVSQRVTFGDVWALLVDGN   60
			  	61   FGSGLPPAEPFPLPIHSGDVRVDVQAGLAMLAPIWGYAPLLDIDDATARQQLARASVMAL  120
			  	121  SYVAQSARGIYQPAVPQRIIDECSTVTARFMTRWQGEPDPRHIEAIDAYWVSAAEHGMNA  180
			  	181  STFTARVIASTGADVAAALSGAIGAMSGPLHGGAPARVLPMLDEVERAGDARSVVKGILD  240
			  	241  RGEKLMGFGHRVYRAEDPRARVLRAAAERLGAPRYEVAVAVEQAALSELRERRPDRAIET  300
			  	301  NVEFWAAVVLDFARVPANMMPAMFTCGRTAGWCAHILEQKRLGKLVRPSAIYVGPGPRSP  360
			  	361  ESVDGWERVLTTA

Known structures in the PDB
No Known structures
1 38 75 112 149 186 223 260 297 334 371 Range: 11 to 69  |  Coverage: 15% Citrate_synt Range: 76 to 348  |  Coverage: 72% Citrate_synt Range: 11 to 364  |  Coverage: 94% 1
Number of amino acids : 373
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Citrate_syntPF0028511-69
Citrate_syntPF0028576-348
Mtb Structural Proteome models
Model Number1
Model nameRv0889c
Template1VGM    APDBCREDO
Template coverage8_376
Template Identity(%)29.4
Model coverage(%)94.6
Normalized DOPE score-0.377

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0889cGene nameConfidence Score
Rv1475cacn0.979
Rv1475cacn0.979
Rv1240mdh0.95
Rv1240mdh0.95
Rv0211pckA0.938
Rv2967cpca0.935
Rv2967cpca0.935
Rv2967cpca0.935
Rv2967cpca0.935
Rv2967cpca0.935
Rv2967cpca0.935
Rv1074cfadA30.916
Rv1074cfadA30.916
Rv3556cfadA60.915
Rv3556cfadA60.915
Rv0859fadA0.914
Rv1867Rv18670.914
Rv0859fadA0.914
Rv0243fadA20.912
Rv0243fadA20.912
Rv2215dlaT0.911
Rv2215dlaT0.911
Rv2215dlaT0.911
Rv3546fadA50.91
Rv1837cglcB0.91
Rv3546fadA50.91
Rv1323fadA40.907
Rv0914cRv0914c0.907
Rv1323fadA40.907
Rv0914cRv0914c0.907
Rv3523ltp30.906
Rv2495cbkdC0.905
Rv2495cbkdC0.905
Rv2495cbkdC0.905
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
citratePubChem0.95192.124
oxaloacetatePubChem0.931132.072
coenzyme APubChem0.927767.534
acetyl-CoAPubChem0.917809.571
Co-APubChem0.916767.534
glyoxylatePubChem0.90874.0355
pyruvic acidPubChem0.90588.0621
cis-aconitatePubChem0.903174.108
phosphatePubChem0.90296.9872
NAD+PubChem0.901663.425
malyl-CoAPubChem0.9883.606
malatePubChem0.9134.087
deuteriumPubChem0.92.01588
acetyl coenzyme-APubChem0.9809.571
formatePubChem0.945.0174
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
D-malatePubChem0.9134.087
malyl coenzyme APubChem0.9883.606
phosphoenolpyruvatePubChem0.9168.042
protiumPubChem0.92.01576
carbon dioxidePubChem0.944.0095
H(+)PubChem0.92.01588
hydroxyl radicalsPubChem0.917.0073