Rv2967c

Tuberculist information
Gene namepca
Protein functionProbable pyruvate carboxylase Pca (pyruvic carboxylase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3319.66
Molecular mass(da)120392
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 1127
	  		  	1    VFSKVLVANRGEIAIRAFRAAYELGVGTVAVYPYEDRNSQHRLKADESYQIGDIGHPVHA   60
			  	61   YLSVDEIVATARRAGADAIYPGYGFLSENPDLAAACAAAGISFVGPSAEVLELAGNKSRA  120
			  	121  IAAAREAGLPVLMSSAPSASVDELLSVAAGMPFPLFVKAVAGGGGRGMRRVGDIAALPEA  180
			  	181  IEAASREAESAFGDPTVYLEQAVINPRHIEVQILADNLGDVIHLYERDCSVQRRHQKVIE  240
			  	241  LAPAPHLDAELRYKMCVDAVAFARHIGYSCAGTVEFLLDERGEYVFIEMNPRVQVEHTVT  300
			  	301  EEITDVDLVASQLRIAAGETLEQLGLRQEDIAPHGAALQCRITTEDPANGFRPDTGRISA  360
			  	361  LRTAGGAGVRLDGSTNLGAEISPYFDSMLVKLTCRGRDLPTAVSRARRAIAEFRIRGVST  420
			  	421  NIPFLQAVLDDPDFRAGRVTTSFIDERPQLLTARASADRGTKILNFLADVTVNNPYGSRP  480
			  	481  STIYPDDKLPDLDLRAAPPAGSKQRLVKLGPEGFARWLRESAAVGVTDTTFRDAHQSLLA  540
			  	541  TRVRTSGLSRVAPYLARTMPQLLSVECWGGATYDVALRFLKEDPWERLATLRAAMPNICL  600
			  	601  QMLLRGRNTVGYTPYPEIVTSAFVQEATATGIDIFRIFDALNNIESMRPAIDAVRETGSA  660
			  	661  IAEVAMCYTGDLTDPGEQLYTLDYYLKLAEQIVDAGAHVLAIKDMAGLLRPPAAQRLVSA  720
			  	721  LRSRFDLPVHLHTHDTPGGQLASYVAAWHAGADAVDGAAAPLAGTTSQPALSSIVAAAAH  780
			  	781  TEYDTGLSLSAVCALEPYWEALRKVYAPFESGLPGPTGRVYHHEIPGGQLSNLRQQAIAL  840
			  	841  GLGDRFEEIEEAYAGADRVLGRLVKVTPTSKVVGDLALALVGAGVSADEFASDPARFGIP  900
			  	901  ESVLGFLRGELGDPPGGWPEPLRTAALAGRGAARPTAQLAADDEIALSSVGAKRQATLNR  960
			  	961  LLFPSPTKEFNEHREAYGDTSQLSANQFFYGLRQGEEHRVKLERGVELLIGLEAISEPDE 1020
			  	1021 RGMRTVMCILNGQLRPVLVRDRSIASAVPAAEKADRGNPGHIAAPFAGVVTVGVCVGERV 1080
			  	1081 GAGQTIATIEAMKMEAPITAPVAGTVERVAVSDTAQVEGGDLLVVVS

Known structures in the PDB
PDB ID1L1E
Total residue count574
Number of chains2
MethodX-RAY
Resolution2
1 113 225 337 449 561 673 785 897 1009 1121 Range: 1 to 111  |  Coverage: 9% CPSase_L_chain Range: 116 to 324  |  Coverage: 18% CPSase_L_D2 Range: 339 to 445  |  Coverage: 9% Biotin_carb_C Range: 532 to 782  |  Coverage: 22% HMGL-like Range: 820 to 1012  |  Coverage: 17% PYC_OADA Range: 1059 to 1126  |  Coverage: 5% Biotin_lipoyl Range: 1 to 453  |  Coverage: 40% 1 Range: 1 to 1126  |  Coverage: 99% 1 Range: 1 to 448  |  Coverage: 39% 2 Range: 532 to 782  |  Coverage: 22% 3 Range: 116 to 324  |  Coverage: 18% 4 Range: 1 to 335  |  Coverage: 29% 5 Range: 947 to 1046  |  Coverage: 8% 6 Range: 824 to 992  |  Coverage: 14% 7 Range: 1043 to 1127  |  Coverage: 7% 8 Range: 334 to 448  |  Coverage: 10% 9 Range: 115 to 396  |  Coverage: 24% 10 Range: 1 to 111  |  Coverage: 9% 11
Number of amino acids : 1127
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CPSase_L_chainPF002891-111
CPSase_L_D2PF02786116-324
Biotin_carb_CPF02785339-445
HMGL-likePF00682532-782
PYC_OADAPF02436820-1012
Biotin_lipoylPF003641059-1126
Mtb Structural Proteome models
Model Number1
Model nameRv2967c
Template1ULZ    APDBCREDO
Template coverage1_449
Template Identity(%)45.2
Model coverage(%)40.1
Normalized DOPE score-0.571

Structure Models from Chopin
Model Number1
Profile2.40.50.100, 3.10.600.10, 3.20.20.70, 3.30.470.20, 3.40.50.20
Click for model details
zscore128.28
Residue begin1
Residue end1126
Model Number2
Profileb.84.2.1, c.30.1.1, d.142.1.2 - 3.30.1490.20, 3.30.470.20
Click for model details
zscore60.46
Residue begin1
Residue end448
Model Number3
Profilec.1.10.5
Click for model details
zscore34.29
Residue begin532
Residue end782
Model Number4
Profiled.142.1.2
Click for model details
zscore22.08
Residue begin116
Residue end324
Model Number5
Profilec.30.1.2, d.142.1.1 - 3.30.1490.20, 3.30.470.20, 3.40.50.20
Click for model details
zscore20.52
Residue begin1
Residue end335
Model Number6
Profile3.10.600.10
Click for model details
zscore19.88
Residue begin947
Residue end1046
Model Number7
Profilea.5.7.2
Click for model details
zscore19.58
Residue begin824
Residue end992
Model Number8
Profileb.84.1.1 - 2.40.50.100
Click for model details
zscore15.88
Residue begin1043
Residue end1127
Model Number9
Profileb.84.2.1
Click for model details
zscore15.15
Residue begin334
Residue end448
Model Number10
Profiled.142.1.2
Click for model details
zscore11.45
Residue begin115
Residue end396
Model Number11
Profilec.30.1.1
Click for model details
zscore7.7
Residue begin1
Residue end111
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2967cGene nameConfidence Score
Rv1617pykA0.997
Rv1617pykA0.997
Rv2332mez0.996
Rv2332mez0.996
Rv1240mdh0.993
Rv1240mdh0.993
Rv0211pckA0.984
Rv1131prpC0.983
Rv0896gltA20.979
Rv2852cmqo0.977
Rv1127cppdK0.977
Rv1127cppdK0.977
Rv2496cbkdB0.967
Rv2496cbkdB0.967
Rv2498ccitE0.951
Rv1493mutB0.948
Rv1493mutB0.948
Rv2497cbkdA0.943
Rv2241aceE0.942
Rv0889ccitA0.935
Rv3667acs0.933
Rv3667acs0.933
Rv0694lldD10.932
Rv0467icl10.931
Rv0337caspC0.93
Rv3003cilvB10.928
Rv3003cilvB10.928
Rv3003cilvB10.928
Rv3279cbirA0.927
Rv3279cbirA0.927
Rv1872clldD20.925
Rv3858cgltD0.918
Rv3858cgltD0.918
Rv3858cgltD0.918
Rv3710leuA0.917
Rv3710leuA0.917
Rv3075cRv3075c0.916
Rv1837cglcB0.907
Rv0843Rv08430.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
oxaloacetatePubChem0.991132.072
aspartatePubChem0.979133.103
manganesePubChem0.97754.938
pyruvic acidPubChem0.97688.0621
bicarbonatePubChem0.96962.0248
alpha-ketoglutaratePubChem0.965146.098
phosphatePubChem0.96396.9872
adenosine triphosphatePubChem0.962507.181
adenosine diphosphatePubChem0.961427.201
glutamatePubChem0.961147.129
d-biotinPubChem0.941244.311
carbon dioxidePubChem0.93944.0095
H(+)PubChem0.9032.01588
deuteriumPubChem0.9032.01588
protiumPubChem0.92.01576
potassium aspartatePubChem0.9133.103
lactatePubChem0.88690.0779
magnesiumPubChem0.86424.305
glycerolPubChem0.83492.0938
coenzyme APubChem0.819767.534
phosphoenolpyruvatePubChem0.816168.042
acetyl-CoAPubChem0.795809.571
glyoxylatePubChem0.79374.0355
BtiPubChem0.724228.311
Co-APubChem0.709767.534
acetatePubChem0.70859.044
formatePubChem0.745.0174
succinatePubChem0.7118.088