Rv0211

Tuberculist information
Gene namepckA
Protein functionProbable iron-regulated phosphoenolpyruvate carboxykinase [GTP] PckA (phosphoenolpyruvate carboxylase) (PEPCK)(pep carboxykinase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)251.782
Molecular mass(da)67253.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 606
	  		  	1    MTSATIPGLDTAPTNHQGLLSWVEEVAELTQPDRVVFTDGSEEEFQRLCDQLVEAGTFIR   60
			  	61   LNPEKHKNSYLALSDPSDVARVESRTYICSAKEIDAGPTNNWMDPGEMRSIMKDLYRGCM  120
			  	121  RGRTMYVVPFCMGPLGAEDPKLGVEITDSEYVVVSMRTMTRMGKAALEKMGDDGFFVKAL  180
			  	181  HSVGAPLEPGQKDVAWPCSETKYITHFPETREIWSYGSGYGGNALLGKKCYSLRIASAMA  240
			  	241  HDEGWLAEHMLILKLISPENKAYYFAAAFPSACGKTNLAMLQPTIPGWRAETLGDDIAWM  300
			  	301  RFGKDGRLYAVNPEFGFFGVAPGTNWKSNPNAMRTIAAGNTVFTNVALTDDGDVWWEGLE  360
			  	361  GDPQHLIDWKGNDWYFRETETNAAHPNSRYCTPMSQCPILAPEWDDPQGVPISGILFGGR  420
			  	421  RKTTVPLVTEARDWQHGVFIGATLGSEQTAAAEGKVGNVRRDPMAMLPFLGYNVGDYFQH  480
			  	481  WINLGKHADESKLPKVFFVNWFRRGDDGRFLWPGFGENSRVLKWIVDRIEHKAGGATTPI  540
			  	541  GTVPAVEDLDLDGLDVDAADVAAALAVDADEWRQELPLIEEWLQFVGEKLPTGVKDEFDA  600
			  	601  LKERLG

Known structures in the PDB
No Known structures
1 61 121 181 241 301 361 421 481 541 601 Range: 21 to 606  |  Coverage: 96% PEPCK Range: 9 to 605  |  Coverage: 98% 1 Range: 1 to 606  |  Coverage: 99% 1 Range: 245 to 606  |  Coverage: 59% 2 Range: 294 to 398  |  Coverage: 17% 3 Range: 2 to 245  |  Coverage: 40% 4
Number of amino acids : 606
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PEPCKPF0082121-606
Mtb Structural Proteome models
Model Number1
Model nameRv0211
Template1KHB    APDBCREDO
Template coverage20_619
Template Identity(%)53.1
Model coverage(%)98.3
Normalized DOPE score-1.172

Structure Models from Chopin
Model Number1
Profile2.170.8.10, 3.40.449.10, 3.90.228.20
Click for model details
zscore52.12
Residue begin1
Residue end606
Model Number2
Profilec.91.1.1
Click for model details
zscore34.68
Residue begin245
Residue end606
Model Number3
Profile2.170.8.10
Click for model details
zscore20.96
Residue begin294
Residue end398
Model Number4
Profile3.40.449.10
Click for model details
zscore19.98
Residue begin2
Residue end245
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0211Gene nameConfidence Score
Rv2967cpca0.984
Rv2967cpca0.984
Rv2967cpca0.984
Rv2967cpca0.984
Rv2967cpca0.984
Rv2967cpca0.984
Rv1617pykA0.978
Rv1617pykA0.978
Rv0896gltA20.976
Rv1127cppdK0.969
Rv1127cppdK0.969
Rv1240mdh0.966
Rv1240mdh0.966
Rv1023eno0.962
Rv1023eno0.962
Rv1131prpC0.955
Rv0889ccitA0.938
Rv2852cmqo0.907
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
phosphoenolpyruvatePubChem0.986168.042
oxaloacetatePubChem0.985132.072
guanosine triphosphatePubChem0.947523.18
guanosine diphosphatePubChem0.936443.201
carbon dioxidePubChem0.93244.0095
manganesePubChem0.82454.938
acetatePubChem0.77959.044
palmitatePubChem0.71256.424