Rv1240

Tuberculist information
Gene namemdh
Protein functionProbable malate dehydrogenase Mdh
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1383.21
Molecular mass(da)34289.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 329
	  		  	1    VSASPLKVAVTGAAGQIGYSLLFRLASGSLLGPDRPIELRLLEIEPALQALEGVVMELDD   60
			  	61   CAFPLLSGVEIGSDPQKIFDGVSLALLVGARPRGAGMERSDLLEANGAIFTAQGKALNAV  120
			  	121  AADDVRVGVTGNPANTNALIAMTNAPDIPRERFSALTRLDHNRAISQLAAKTGAAVTDIK  180
			  	181  KMTIWGNHSATQYPDLFHAEVAGKNAAEVVNDQAWIEDEFIPTVAKRGAAIIDARGASSA  240
			  	241  ASAASATIDAARDWLLGTPADDWVSMAVVSDGSYGVPEGLISSFPVTTKGGNWTIVSGLE  300
			  	301  IDEFSRGRIDKSTAELADERSAVTELGLI

Known structures in the PDB
No Known structures
1 33 65 97 129 161 193 225 257 289 321 Range: 6 to 155  |  Coverage: 45% Ldh_1_N Range: 157 to 326  |  Coverage: 51% Ldh_1_C Range: 3 to 329  |  Coverage: 99% 1 Range: 1 to 329  |  Coverage: 99% 1 Range: 157 to 326  |  Coverage: 51% 2 Range: 6 to 155  |  Coverage: 45% 3 Range: 1 to 316  |  Coverage: 95% 4
Number of amino acids : 329
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Ldh_1_NPF000566-155
Ldh_1_CPF02866157-326
Mtb Structural Proteome models
Model Number1
Model nameRv1240
Template1Y7T    APDBCREDO
Template coverage1_332
Template Identity(%)63.8
Model coverage(%)99.1
Normalized DOPE score-1.145

Structure Models from Chopin
Model Number1
Profilec.2.1.5, d.162.1.1 - 3.40.50.720, 3.90.110.10
Click for model details
zscore35.92
Residue begin1
Residue end329
Model Number2
Profiled.162.1.1
Click for model details
zscore25.4
Residue begin157
Residue end326
Model Number3
Profilec.2.1.5
Click for model details
zscore23.01
Residue begin6
Residue end155
Model Number4
Profilec.2.1.5
Click for model details
zscore13.16
Residue begin1
Residue end316
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1240Gene nameConfidence Score
Rv1131prpC0.996
Rv2967cpca0.993
Rv1098cfum0.993
Rv2967cpca0.993
Rv1098cfum0.993
Rv2967cpca0.993
Rv2967cpca0.993
Rv2967cpca0.993
Rv2967cpca0.993
Rv0896gltA20.991
Rv0952sucD0.991
Rv0952sucD0.991
Rv2332mez0.99
Rv2332mez0.99
Rv0951sucC0.986
Rv0951sucC0.986
Rv1617pykA0.976
Rv1617pykA0.976
Rv0946cpgi0.974
Rv1437pgk0.967
Rv0211pckA0.966
Rv2498ccitE0.963
Rv1023eno0.963
Rv0733adk0.963
Rv1023eno0.963
Rv2852cmqo0.96
Rv3319sdhB0.95
Rv0889ccitA0.95
Rv3319sdhB0.95
Rv0337caspC0.948
Rv0467icl10.945
Rv1475cacn0.944
Rv1837cglcB0.944
Rv1438tpi0.944
Rv1475cacn0.944
Rv3339cicd10.941
Rv1436gap0.938
Rv1436gap0.938
Rv1493mutB0.934
Rv1493mutB0.934
Rv2213pepB0.926
Rv2213pepB0.926
Rv3075cRv3075c0.924
Rv3318sdhA0.919
Rv3318sdhA0.919
Rv1248cRv1248c0.91
Rv3858cgltD0.91
Rv3858cgltD0.91
Rv3858cgltD0.91
Rv1248cRv1248c0.91
Rv1248cRv1248c0.91
Rv2476cgdh0.908
Rv1659argH0.902
Rv1659argH0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00336DrugBankNitrofurazone
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NAD+PubChem0.994663.425
malatePubChem0.992134.087
oxaloacetatePubChem0.985132.072
citratePubChem0.968192.124
aspartatePubChem0.967133.103
alpha-ketoglutaratePubChem0.966146.098
glyoxylatePubChem0.96274.0355
phosphoenolpyruvatePubChem0.948168.042
fumaratePubChem0.943116.072
NADPPubChem0.941744.413
phosphatePubChem0.94196.9872
glutamatePubChem0.938147.129
acetyl-CoAPubChem0.936809.571
D-malatePubChem0.932134.087
H(+)PubChem0.9312.01588
deuteriumPubChem0.932.01588
adenosine diphosphatePubChem0.924427.201
carbon dioxidePubChem0.90444.0095
reduced nicotinamide adenine dinucleotidePubChem0.901665.441
malyl-CoAPubChem0.9883.606
malyl coenzyme APubChem0.9883.606
potassium aspartatePubChem0.9133.103
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
hydroxyl radicalsPubChem0.917.0073
coenzyme APubChem0.9767.534
protiumPubChem0.92.01576
acetyl coenzyme-APubChem0.9809.571
adenosine triphosphatePubChem0.9507.181
Co-APubChem0.9767.534
NADP(H)PubChem0.872745.421
magnesiumPubChem0.75124.305
Tris-HClPubChem0.722121.135
Na(+)PubChem0.71622.9898
NaXPubChem0.709683.456