Rv2852c

Tuberculist information
Gene namemqo
Protein functionProbable malate:quinone oxidoreductase Mqo (malate dehydrogenase [acceptor])
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3160.58
Molecular mass(da)53563.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 493
	  		  	1    VSDLARTDVVLIGAGIMSATLGVLLRRLEPNWSITLIERLDAVAAESSGPWNNAGTGHSA   60
			  	61   LCEMNYTPEMPDGSIDITKAVRVNEQFQVTRQFWAYAAENGILTDVRSFLNPVPHVSFVH  120
			  	121  GSRGVEYLRRRQKALAGNPLFAGTEFIESPDEFARRLPFMAAKRAFSEPVALNWAADGTD  180
			  	181  VDFGALAKQLIGYCVQNGTTALFGHEVRNLSRQSDGSWTVTMCNRRTGEKRKLNTKFVFV  240
			  	241  GAGGDTLPVLQKSGIKEVKGFAGFPIGGRFLRAGNPALTASHRAKVYGFPAPGAPPLGAL  300
			  	301  HLDLRFVNGKSWLVFGPYAGWSPKFLKHGQISDLPRSIRPDNLLSVLGVGLTERRLLNYL  360
			  	361  ISQLRLSEPERVSALREFAPSAIDSDWELTIAGQRVQVIRRDERNGGVLEFGTTVIGDAD  420
			  	421  GSIAGLLGGSPGASTAVAIMLDVLQKCFANRYQSWLPTLKEMVPSLGVQLSNEPALFDEV  480
			  	481  WSWSTKALKLGAA

Known structures in the PDB
No Known structures
1 50 99 148 197 246 295 344 393 442 491 Range: 3 to 490  |  Coverage: 98% Mqo Range: 6 to 489  |  Coverage: 97% 1
Number of amino acids : 493
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MqoPF060393-490
Mtb Structural Proteome models
Model Number1
Model nameRv2852c
Template1PJ5    APDBCREDO
Template coverage4_412
Template Identity(%)14.4
Model coverage(%)98.0
Normalized DOPE score0.517

Structure Models from Chopin
CHOPIN models not available for this query
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2852cGene nameConfidence Score
Rv2967cpca0.977
Rv2967cpca0.977
Rv2967cpca0.977
Rv2967cpca0.977
Rv2967cpca0.977
Rv2967cpca0.977
Rv2332mez0.969
Rv2332mez0.969
Rv1240mdh0.96
Rv1240mdh0.96
Rv0896gltA20.939
Rv1131prpC0.936
Rv1837cglcB0.91
Rv0211pckA0.907
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
malatePubChem0.976134.087
oxaloacetatePubChem0.973132.072
ubiquinonesPubChem0.71250.29