Rv2332

Tuberculist information
Gene namemez
Protein functionProbable [NAD] dependent malate oxidoreductase Mez (malic enzyme) (NAD-malic enzyme) (malate dehydrogenase (oxaloacetate decarboxylating)) (pyruvic-malic carboxylase) (NAD-me)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2605.11
Molecular mass(da)59422.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 548
	  		  	1    MSDARVPRIPAALSAPSLNRGVGFTHAQRRRLGLTGRLPSAVLTLDQQAERVWHQLQSLA   60
			  	61   TELGRNLLLEQLHYRHEVLYFKVLADHLPELMPVVYTPTVGEAIQRFSDEYRGQRGLFLS  120
			  	121  IDEPDEIEEAFNTLGLGPEDVDLIVCTDAEAILGIGDWGVGGIQIAVGKLALYTAGGGVD  180
			  	181  PRRCLAVSLDVGTDNEQLLADPFYLGNRHARRRGREYDEFVSRYIETAQRLFPRAILHFE  240
			  	241  DFGPANARKILDTYGTDYCVFNDDMQGTGAVVLAAVYSGLKVTGIPLRDQTIVVFGAGTA  300
			  	301  GMGIADQIRDAMVADGATLEQAVSQIWPIDRPGLLFDDMDDLRDFQVPYAKNRHQLGVAV  360
			  	361  GDRVGLSDAIKIASPTILLGCSTVYGAFTKEVVEAMTASCKHPMIFPLSNPTSRMEAIPA  420
			  	421  DVLAWSNGRALLATGSPVAPVEFDETTYVIGQANNVLAFPGIGLGVIVAGARLITRRMLH  480
			  	481  AAAKAIAHQANPTNPGDSLLPDVQNLRAISTTVAEAVYRAAVQDGVASRTHDDVRQAIVD  540
			  	541  TMWLPAYD

Known structures in the PDB
No Known structures
1 55 109 163 217 271 325 379 433 487 541 Range: 73 to 255  |  Coverage: 33% malic Range: 265 to 522  |  Coverage: 46% Malic_M Range: 7 to 548  |  Coverage: 98% 1 Range: 4 to 548  |  Coverage: 99% 1 Range: 5 to 262  |  Coverage: 46% 2 Range: 73 to 255  |  Coverage: 33% 3 Range: 265 to 522  |  Coverage: 46% 4 Range: 11 to 543  |  Coverage: 97% 5
Number of amino acids : 548
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
malicPF0039073-255
Malic_MPF03949265-522
Mtb Structural Proteome models
Model Number1
Model nameRv2332
Template1GQ2    APDBCREDO
Template coverage23_563
Template Identity(%)37.4
Model coverage(%)98.7
Normalized DOPE score-0.984

Structure Models from Chopin
Model Number1
Profilec.2.1.7, c.58.1.3 - 3.40.50.10380, 3.40.50.720
Click for model details
zscore77.43
Residue begin4
Residue end548
Model Number2
Profile3.40.50.10380
Click for model details
zscore50.8
Residue begin5
Residue end262
Model Number3
Profilec.58.1.3
Click for model details
zscore43.08
Residue begin73
Residue end255
Model Number4
Profilec.2.1.7
Click for model details
zscore15.64
Residue begin265
Residue end522
Model Number5
Profilec.2.1.7
Click for model details
zscore8.17
Residue begin11
Residue end543
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2332Gene nameConfidence Score
Rv1617pykA0.997
Rv1617pykA0.997
Rv2967cpca0.996
Rv2967cpca0.996
Rv2967cpca0.996
Rv2967cpca0.996
Rv2967cpca0.996
Rv2967cpca0.996
Rv1240mdh0.99
Rv1240mdh0.99
Rv2852cmqo0.969
Rv2241aceE0.951
Rv2497cbkdA0.943
Rv0694lldD10.941
Rv1127cppdK0.939
Rv1127cppdK0.939
Rv1131prpC0.936
Rv2496cbkdB0.933
Rv2496cbkdB0.933
Rv1837cglcB0.931
Rv2988cleuC0.93
Rv0896gltA20.929
Rv1872clldD20.924
Rv3003cilvB10.913
Rv3003cilvB10.913
Rv3003cilvB10.913
Rv0843Rv08430.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
malatePubChem0.993134.087
NAD+PubChem0.972663.425
phosphoenolpyruvatePubChem0.967168.042
pyruvic acidPubChem0.94888.0621
carbon dioxidePubChem0.94344.0095
reduced nicotinamide adenine dinucleotidePubChem0.941665.441
H(+)PubChem0.9312.01588
deuteriumPubChem0.9312.01588
D-malatePubChem0.926134.087
phosphatePubChem0.92296.9872
adenosine triphosphatePubChem0.92507.181
adenosine monophosphatePubChem0.915347.221
protiumPubChem0.9052.01576
hydroxyl radicalsPubChem0.90317.0073
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
fumaratePubChem0.797116.072
NADPPubChem0.79744.413
lactatePubChem0.72590.0779
oxaloacetatePubChem0.725132.072
malic acidPubChem0.708134.087