Rv1127c

Tuberculist information
Gene nameppdK
Protein functionProbable pyruvate, phosphate dikinase PpdK
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1249.93
Molecular mass(da)52004.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 490
	  		  	1    MTRITRANGCPDGTLENAVVALDGGANYPREILGNKGHGIDMMRRHHLPVPPAFCITTEV   60
			  	61   GVRYLAAPGSTIAAIWDDVLDRMSWLETETSCTFGRGPNPLLVSVRSGATQSMPGMMDTI  120
			  	121  LDVGMTDAVERVLARPGAADFAHDTRRRFTSMYRRIVGSAGPITDDPYAQLRASIEAVFA  180
			  	181  SWNSPRAVAYRDHHGLDDQGGTAVVVQAMVFGNLTANSGAGVLSSRNPITGANEPFGEWL  240
			  	241  PGGQGDDVVSGLVAVAPITALRDQQPAVYDQLMAAARSLERMAGDVQEIEFTVEDSQLWL  300
			  	301  LQTRGAERSAQAAVRLALQLHHEGLIDDTETLRRVTPTHIETLLRPSLQTETRLAAPLLA  360
			  	361  KGLPACPGVVSGTAYTEVDEALDAADRGEPVILVRDHTRPEDVMGMLAAQGIVTEVGGAA  420
			  	421  SHAAVVSRELGRVAVVGCGPGVAAALAGKEITVDGYEGEVRQGVLALSAWSESDTPELRE  480
			  	481  LADIAQRISS

Known structures in the PDB
No Known structures
1 50 99 148 197 246 295 344 393 442 491 Range: 26 to 329  |  Coverage: 61% PPDK_N Range: 380 to 458  |  Coverage: 15% PEP-utilizers Range: 16 to 489  |  Coverage: 96% 1 Range: 10 to 490  |  Coverage: 97% 1 Range: 26 to 329  |  Coverage: 61% 2 Range: 343 to 470  |  Coverage: 25% 3 Range: 380 to 458  |  Coverage: 15% 4 Range: 309 to 384  |  Coverage: 15% 5
Number of amino acids : 490
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
PPDK_NPF0132626-329
PEP-utilizersPF00391380-458
Mtb Structural Proteome models
Model Number1
Model nameRv1127c
Template1H6Z    APDBCREDO
Template coverage3_560
Template Identity(%)38.8
Model coverage(%)96.5
Normalized DOPE score0.373

Structure Models from Chopin
Model Number1
Profilec.1.12.2, c.8.1.1, d.142.1.5 - 1.10.189.10, 1.20.80.30, 3.20.20.60, 3.30.1490.20, 3.30.470.20, 3.50.30.10
Click for model details
zscore84.22
Residue begin10
Residue end490
Model Number2
Profiled.142.1.5
Click for model details
zscore55.93
Residue begin26
Residue end329
Model Number3
Profilec.8.1.1
Click for model details
zscore26.48
Residue begin343
Residue end470
Model Number4
Profile3.50.30.10
Click for model details
zscore22.3
Residue begin380
Residue end458
Model Number5
Profile1.10.189.10
Click for model details
zscore13.84
Residue begin309
Residue end384
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1127cGene nameConfidence Score
Rv2967cpca0.977
Rv2967cpca0.977
Rv2967cpca0.977
Rv2967cpca0.977
Rv2967cpca0.977
Rv2967cpca0.977
Rv0211pckA0.969
Rv1126cRv1126c0.957
Rv2496cbkdB0.94
Rv2496cbkdB0.94
Rv1617pykA0.94
Rv1617pykA0.94
Rv2332mez0.939
Rv2332mez0.939
Rv1872clldD20.922
Rv0843Rv08430.919
Rv0694lldD10.915
Rv2497cbkdA0.913
Rv0409ackA0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
phosphoenolpyruvatePubChem0.976168.042
pyrophosphatePubChem0.975177.975
adenosine triphosphatePubChem0.958507.181
adenosine monophosphatePubChem0.957347.221
phosphatePubChem0.94396.9872
deuteriumPubChem0.92.01588
pyruvic acidPubChem0.988.0621
protiumPubChem0.92.01576
H(+)PubChem0.92.01588
pyruvate phosphatePubChem0.708269.08