Rv1872c

Tuberculist information
Gene namelldD2
Protein functionPossible L-lactate dehydrogenase (cytochrome) LldD2
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2121.91
Molecular mass(da)45341.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 414
	  		  	1    MAVNRRVPRVRDLAPLLQFNRPQFDTSKRRLGAALTIQDLRRIAKRRTPRAAFDYADGGA   60
			  	61   EDELSIARARQGFRDIEFHPTILRDVTTVCAGWNVLGQPTVLPFGIAPTGFTRLMHTEGE  120
			  	121  IAGARAAAAAGIPFSLSTLATCAIEDLVIAVPQGRKWFQLYMWRDRDRSMALVRRVAAAG  180
			  	181  FDTMLVTVDVPVAGARLRDVRNGMSIPPALTLRTVLDAMGHPRWWFDLLTTEPLAFASLD  240
			  	241  RWPGTVGEYLNTVFDPSLTFDDLAWIKSQWPGKLVVKGIQTLDDARAVVDRGVDGIVLSN  300
			  	301  HGGRQLDRAPVPFHLLPHVARELGKHTEILVDTGIMSGADIVAAIALGARCTLIGRAYLY  360
			  	361  GLMAGGEAGVNRAIEILQTGVIRTMRLLGVTCLEELSPRHVTQLRRLGPIGAPT

Known structures in the PDB
No Known structures
1 42 83 124 165 206 247 288 329 370 411 Range: 44 to 403  |  Coverage: 86% FMN_dh Range: 33 to 401  |  Coverage: 88% 1 Range: 1 to 414  |  Coverage: 99% 1
Number of amino acids : 414
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
FMN_dhPF0107044-403
Mtb Structural Proteome models
Model Number1
Model nameRv1872c
Template1P4C    APDBCREDO
Template coverage4_353
Template Identity(%)38.9
Model coverage(%)88.9
Normalized DOPE score-0.441

Structure Models from Chopin
Model Number1
Profilec.1.4.1 - 3.20.20.70
Click for model details
zscore19.28
Residue begin1
Residue end414
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1872cGene nameConfidence Score
Rv1617pykA0.969
Rv1617pykA0.969
Rv0694lldD10.931
Rv2967cpca0.925
Rv2967cpca0.925
Rv2967cpca0.925
Rv2967cpca0.925
Rv2967cpca0.925
Rv2967cpca0.925
Rv2332mez0.924
Rv2332mez0.924
Rv2241aceE0.923
Rv1127cppdK0.922
Rv1127cppdK0.922
Rv2496cbkdB0.92
Rv2496cbkdB0.92
Rv3509cilvX0.912
Rv3509cilvX0.912
Rv2497cbkdA0.91
Rv1905caao0.909
Rv0843Rv08430.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
lactatePubChem0.9890.0779
L-lactatePubChem0.96690.0779
pyruvic acidPubChem0.94588.0621
flavin mononucleotidePubChem0.779456.344