Rv3509c

Tuberculist information
Gene nameilvX
Protein functionProbable acetohydroxyacid synthase IlvX (acetolactate synthase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3936.88
Molecular mass(da)52040.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 515
	  		  	1    VNGAQALINTLVDGGVDVCFANPGTSEMHFVAALDAVPRMRGMLTLFEGVATGAADGYAR   60
			  	61   IAGRPAAVLLHLGPGLGNGLANLHNARRARVPMVVVVGDHATYHKKYDAPLESDIDAVAG  120
			  	121  TVSGWVRRTEAAADVGADAEAAIAASRSGSQIATLILPADVCWSDGAHAAAGVPAQAAAA  180
			  	181  PVDVGPVAGVLRSGEPAMMLIGGDATRGPGLTAAARIVQATGARWLCETFPTCLERGAGI  240
			  	241  PAVERLAYFAEGAAAQLDGVKHLVLAGARSPVSFFAYPGMPSDLVPAGCEVHVLAEPGGA  300
			  	301  ADALAALADEVAPGTVAPVAGASRPQLPTGDLTSVSAADVVGALLPERAIVVDESNTCGV  360
			  	361  LLPQATAGAPAHDWLTLTGGAIGYGIPAAVGAAVAAPDRPVLCLESDGSAMYTISGLWSQ  420
			  	421  ARENLDVTTVIYNNGAYDILRIELQRVGAGSDPGPKALDLLDISRPTMDFVKIAEGMGVP  480
			  	481  ARRVTTCEEFADALRAAFAEPGPHLIDVVVPSLVG

Known structures in the PDB
No Known structures
1 52 103 154 205 256 307 358 409 460 511 Range: 1 to 169  |  Coverage: 32% TPP_enzyme_N Range: 360 to 508  |  Coverage: 28% TPP_enzyme_C Range: 9 to 510  |  Coverage: 97% 1 Range: 1 to 515  |  Coverage: 99% 1 Range: 1 to 169  |  Coverage: 32% 2 Range: 360 to 508  |  Coverage: 28% 3 Range: 315 to 515  |  Coverage: 38% 4 Range: 164 to 345  |  Coverage: 35% 5
Number of amino acids : 515
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
TPP_enzyme_NPF027761-169
TPP_enzyme_CPF02775360-508
Mtb Structural Proteome models
Model Number1
Model nameRv3509c
Template1Q6Z    APDBCREDO
Template coverage10_523
Template Identity(%)24.9
Model coverage(%)97.3
Normalized DOPE score0.266

Structure Models from Chopin
Model Number1
Profilec.31.1.3, c.36.1.5, c.36.1.9 - 1.20.5.740, 3.40.50.1220, 3.40.50.970
Click for model details
zscore79.76
Residue begin1
Residue end515
Model Number2
Profilec.36.1.5
Click for model details
zscore29.54
Residue begin1
Residue end169
Model Number3
Profilec.36.1.9
Click for model details
zscore24.91
Residue begin360
Residue end508
Model Number4
Profilec.36.1.9
Click for model details
zscore16.33
Residue begin315
Residue end515
Model Number5
Profilec.31.1.3
Click for model details
zscore8.26
Residue begin164
Residue end345
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3509cGene nameConfidence Score
Rv1872clldD20.912
Rv2241aceE0.904
Rv3001cilvC0.903
Rv3001cilvC0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
NADPPubChem0.904744.413
carbon dioxidePubChem0.90344.0095
deuteriumPubChem0.9032.01588
C05125PubChem0.9469.367
C04272PubChem0.9134.13
ammoniaPubChem0.917.0305
(S)-2-acetolactatePubChem0.9132.115
alpha,beta-dihydroxyisovaleric acidPubChem0.9134.13
(2R,3R)-2,3-dihydroxy-3-methylvaleratePubChem0.9148.157
2,3-dihydroxy-3-methylpentanoic acidPubChem0.9148.157
CID-22PubChem0.9132.115
pyruvic acidPubChem0.988.0621
L-allo-threoninePubChem0.9119.119
L-threoninePubChem0.9119.119
C06006PubChem0.9146.141
protiumPubChem0.92.01576
CID-21PubChem0.9146.141
NADP(H)PubChem0.9745.421
H(+)PubChem0.92.01588
alpha-ketobutyratePubChem0.9102.089