Rv3001c

Tuberculist information
Gene nameilvC
Protein functionProbable KETOL-acid reductoisomerase IlvC (acetohydroxy-acid isomeroreductase) (alpha-keto-beta-hydroxylacil reductoisomerase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3359.58
Molecular mass(da)36090.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 333
	  		  	1    MFYDDDADLSIIQGRKVGVIGYGSQGHAHSLSLRDSGVQVRVGLKQGSRSRPKVEEQGLD   60
			  	61   VDTPAEVAKWADVVMVLAPDTAQAEIFAGDIEPNLKPGDALFFGHGLNVHFGLIKPPADV  120
			  	121  AVAMVAPKGPGHLVRRQFVDGKGVPCLVAVEQDPRGDGLALALSYAKAIGGTRAGVIKTT  180
			  	181  FKDETETDLFGEQTVLCGGTEELVKAGFEVMVEAGYPAELAYFEVLHELKLIVDLMYEGG  240
			  	241  LARMYYSVSDTAEFGGYLSGPRVIDAGTKERMRDILREIQDGSFVHKLVADVEGGNKQLE  300
			  	301  ELRRQNAEHPIEVVGKKLRDLMSWVDRPITETA

Known structures in the PDB
No Known structures
1 34 67 100 133 166 199 232 265 298 331 Range: 11 to 175  |  Coverage: 49% IlvN Range: 181 to 326  |  Coverage: 43% IlvC Range: 1 to 325  |  Coverage: 97% 1 Range: 1 to 333  |  Coverage: 99% 1 Range: 181 to 326  |  Coverage: 43% 2 Range: 11 to 175  |  Coverage: 49% 3
Number of amino acids : 333
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
IlvNPF0799111-175
IlvCPF01450181-326
Mtb Structural Proteome models
Model Number1
Model nameRv3001c
Template1NP3    APDBCREDO
Template coverage3_327
Template Identity(%)55.7
Model coverage(%)97.3
Normalized DOPE score-0.645

Structure Models from Chopin
Model Number1
Profilea.100.1.2, c.2.1.6 - 1.10.1040.10, 3.40.50.720
Click for model details
zscore54.92
Residue begin1
Residue end333
Model Number2
Profilea.100.1.2
Click for model details
zscore27.34
Residue begin181
Residue end326
Model Number3
Profilec.2.1.4
Click for model details
zscore11.68
Residue begin11
Residue end175
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3001cGene nameConfidence Score
Rv3003cilvB10.999
Rv3002cilvN0.999
Rv3002cilvN0.999
Rv3003cilvB10.999
Rv3003cilvB10.999
Rv0189cilvD0.999
Rv2210cilvE0.996
Rv1820ilvG0.994
Rv1820ilvG0.994
Rv1559ilvA0.994
Rv1559ilvA0.994
Rv1820ilvG0.994
Rv3710leuA0.993
Rv3710leuA0.993
Rv2995cleuB0.989
Rv2987cleuD0.989
Rv2988cleuC0.988
Rv3470cilvB20.986
Rv3470cilvB20.986
Rv3470cilvB20.986
Rv1133cmetE0.952
Rv1133cmetE0.952
Rv2773cdapB0.948
Rv2773cdapB0.948
Rv1295thrC0.933
Rv3838cpheA0.929
Rv3838cpheA0.929
Rv2883cpyrH0.911
Rv3509cilvX0.903
Rv3509cilvX0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
CID-21PubChem0.959146.141
(2R,3R)-2,3-dihydroxy-3-methylvaleratePubChem0.948148.157
CID-22PubChem0.946132.115
alpha-ketobutyratePubChem0.945102.089
NADPPubChem0.913744.413
NADP(H)PubChem0.902745.421
C06006PubChem0.9146.141
carbon dioxidePubChem0.944.0095
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
alpha-keto-beta-methylvaleric acidPubChem0.9130.142
pyruvic acidPubChem0.988.0621
C04272PubChem0.9134.13
(S)-2-acetolactatePubChem0.9132.115
alpha,beta-dihydroxyisovaleric acidPubChem0.9134.13
2,3-dihydroxy-3-methylpentanoic acidPubChem0.9148.157
hydroxyl radicalsPubChem0.917.0073
2-oxo-3-methylpentanoatePubChem0.9130.142
alpha-ketoisovaleratePubChem0.9116.115
acetolactatePubChem0.724132.115