Rv3470c

Tuberculist information
Gene nameilvB2
Protein functionProbable acetolactate synthase (large subunit) IlvB2 (AHAS) (acetohydroxy-acid synthase large subunit) (ALS)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3887.14
Molecular mass(da)57224.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 552
	  		  	1    VTVGDHLVARMRAAGISVVCGLPTSRLDSLLVRLSRDAGFQIVLARHEGGAGYLADGFAR   60
			  	61   ASGKSAAVFVAGPGATNVISAVANASVNQVPMLILTGEVAVGEFGLHSQQDTSDDGLGLG  120
			  	121  ATFRRFCRCSVSIESIANARSKIDSAFRALASIPRGPVHIALPRDLVDERLPAHQLGTAA  180
			  	181  AGLGGLRTLAPCGPDVADEVIGRLDRSRAPMLVLGNGCRLDGIGEQIVAFCEKAGLPFAT  240
			  	241  TPNGRGIVAETHPLSLGVLGIFGDGRADEYLFDTPCDLLIAVGVSFGGLVTRSFSPRWRG  300
			  	301  LKADVVHVDPDPSAVGRFVATSLGITTSGRAFVNALNCGRPPRFCRRVGVRPPAPAALPG  360
			  	361  TPQARGESIHPLELMHELDRELAPNATICADVGTCISWTFRGIPVRRPGRFFATVDFSPM  420
			  	421  GCGIAGAIGVALARPEEHVICIAGDGAFLMHGTEISTAVAHGIRVTWAVLNDGQMSASAG  480
			  	481  PVSGRMDPSPVARIGANDLAAMARALGAEGIRVDTRCELRAGVQKALAATGPCVLDIAID  540
			  	541  PEINKPDIGLGR

Known structures in the PDB
No Known structures
1 56 111 166 221 276 331 386 441 496 551 Range: 1 to 175  |  Coverage: 31% TPP_enzyme_N Range: 197 to 336  |  Coverage: 25% TPP_enzyme_M Range: 391 to 537  |  Coverage: 26% TPP_enzyme_C Range: 2 to 551  |  Coverage: 99% 1 Range: 1 to 552  |  Coverage: 99% 1 Range: 391 to 537  |  Coverage: 26% 2 Range: 1 to 175  |  Coverage: 31% 3 Range: 352 to 552  |  Coverage: 36% 4 Range: 197 to 336  |  Coverage: 25% 5 Range: 177 to 374  |  Coverage: 35% 6
Number of amino acids : 552
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
TPP_enzyme_NPF027761-175
TPP_enzyme_MPF00205197-336
TPP_enzyme_CPF02775391-537
Mtb Structural Proteome models
Model Number1
Model nameRv3470c
Template1YBH    APDBCREDO
Template coverage98_654
Template Identity(%)25.1
Model coverage(%)99.3
Normalized DOPE score-0.465

Structure Models from Chopin
Model Number1
Profilec.31.1.3, c.36.1.5, c.36.1.9
Click for model details
zscore73.95
Residue begin1
Residue end552
Model Number2
Profilec.36.1.9
Click for model details
zscore30.5
Residue begin391
Residue end537
Model Number3
Profilec.36.1.5
Click for model details
zscore27.97
Residue begin1
Residue end175
Model Number4
Profilec.36.1.9
Click for model details
zscore22.31
Residue begin352
Residue end552
Model Number5
Profilec.31.1.3
Click for model details
zscore21.58
Residue begin197
Residue end336
Model Number6
Profilec.31.1.3
Click for model details
zscore19.74
Residue begin177
Residue end374
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3470cGene nameConfidence Score
Rv3001cilvC0.986
Rv3001cilvC0.986
Rv3002cilvN0.975
Rv3002cilvN0.975
Rv0694lldD10.963
Rv2995cleuB0.952
Rv2241aceE0.943
Rv1559ilvA0.938
Rv1559ilvA0.938
Rv2496cbkdB0.903
Rv2496cbkdB0.903
Rv2497cbkdA0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
DrugBank IDDrug Name
DB00336DrugBankNitrofurazone
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
alpha-ketobutyratePubChem0.912102.089
CID-22PubChem0.908132.115
CID-21PubChem0.907146.141
L-threoninePubChem0.902119.119
deuteriumPubChem0.9022.01588
carbon dioxidePubChem0.90144.0095
H(+)PubChem0.9012.01588
C05125PubChem0.9469.367
C04272PubChem0.9134.13
ammoniaPubChem0.917.0305
(S)-2-acetolactatePubChem0.9132.115
alpha,beta-dihydroxyisovaleric acidPubChem0.9134.13
(2R,3R)-2,3-dihydroxy-3-methylvaleratePubChem0.9148.157
NADPPubChem0.9744.413
2,3-dihydroxy-3-methylpentanoic acidPubChem0.9148.157
pyruvic acidPubChem0.988.0621
L-allo-threoninePubChem0.9119.119
C06006PubChem0.9146.141
protiumPubChem0.92.01576
NADP(H)PubChem0.9745.421