Rv3002c

Tuberculist information
Gene nameilvN
Protein functionProbable acetolactate synthase (small subunit) IlvN (acetohydroxy-acid synthase) (AHAS) (ALS)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3360.62
Molecular mass(da)18186.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 168
	  		  	1    MSPKTHTLSVLVEDKPGVLARVAALFSRRGFNIESLAVGATECKDRSRMTIVVSAEDTPL   60
			  	61   EQITKQLNKLINVIKIVEQDDEHSVSRELALIKVQADAGSRSQVIEAVNLFRANVIDVSP  120
			  	121  ESLTVEATGNRGKLEALLRVLEPFGIREIAQSGMVSLSRGPRGIGTAK

Known structures in the PDB
No Known structures
1 17 33 49 65 81 97 113 129 145 161 Range: 14 to 76  |  Coverage: 36% ACT_5 Range: 86 to 160  |  Coverage: 44% ALS_ss_C Range: 4 to 165  |  Coverage: 95% 1 Range: 3 to 162  |  Coverage: 94% 1 Range: 78 to 166  |  Coverage: 52% 2 Range: 1 to 81  |  Coverage: 47% 3
Number of amino acids : 168
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ACT_5PF1371014-76
ALS_ss_CPF1036986-160
Mtb Structural Proteome models
Model Number1
Model nameRv3002c
Template2FGD    APDBCREDO
Template coverage1_162
Template Identity(%)46.9
Model coverage(%)95.8
Normalized DOPE score-1.306

Structure Models from Chopin
Model Number1
Profiled.58.18.6 - 3.30.70.1150, 3.30.70.260
Click for model details
zscore30.48
Residue begin3
Residue end162
Model Number2
Profiled.58.18.6
Click for model details
zscore16.43
Residue begin78
Residue end166
Model Number3
Profiled.58.18.14 - 3.30.70.1150
Click for model details
zscore8.34
Residue begin1
Residue end81
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3002cGene nameConfidence Score
Rv3003cilvB10.999
Rv3003cilvB10.999
Rv3001cilvC0.999
Rv3001cilvC0.999
Rv3003cilvB10.999
Rv1559ilvA0.996
Rv2995cleuB0.996
Rv1559ilvA0.996
Rv3710leuA0.994
Rv3710leuA0.994
Rv0189cilvD0.99
Rv2987cleuD0.98
Rv2988cleuC0.977
Rv3470cilvB20.975
Rv3470cilvB20.975
Rv3470cilvB20.975
Rv2496cbkdB0.951
Rv2496cbkdB0.951
Rv2241aceE0.946
Rv1820ilvG0.942
Rv1820ilvG0.942
Rv1820ilvG0.942
Rv2497cbkdA0.909
Rv2210cilvE0.905
Rv3838cpheA0.903
Rv3838cpheA0.903
Rv1602hisH0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
alpha-ketobutyratePubChem0.957102.089
CID-21PubChem0.956146.141
selenomethioninePubChem0.908196.106
pyruvic acidPubChem0.988.0621
C06006PubChem0.9146.141
ammoniaPubChem0.917.0305
protiumPubChem0.92.01576
carbon dioxidePubChem0.944.0095
C05125PubChem0.9469.367
(2R,3R)-2,3-dihydroxy-3-methylvaleratePubChem0.9148.157
H(+)PubChem0.92.01588
CID-22PubChem0.9132.115
NADP(H)PubChem0.9745.421
L-threoninePubChem0.9119.119
(S)-2-acetolactatePubChem0.9132.115
deuteriumPubChem0.92.01588
2,3-dihydroxy-3-methylpentanoic acidPubChem0.9148.157
NADPPubChem0.9744.413
L-allo-threoninePubChem0.9119.119
SeMetPubChem0.788196.106
magnesiumPubChem0.78724.305
calciumPubChem0.75340.078
acetolactatePubChem0.716132.115
succinatePubChem0.704118.088
hydron; succinatePubChem0.704119.096