Rv1602

Tuberculist information
Gene namehisH
Protein functionProbable amidotransferase HisH
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1802.66
Molecular mass(da)21386.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 206
	  		  	1    VTAKSVVVLDYGSGNLRSAQRALQRVGAEVEVTADTDAAMTADGLVVPGVGAFAACMAGL   60
			  	61   RKISGERIIAERVAAGRPVLGVCVGMQILFACGVEFGVQTPGCGHWPGAVIRLEAPVIPH  120
			  	121  MGWNVVDSAAGSALFKGLDVDARFYFVHSYAAQRWEGSPDALLTWATYRAPFLAAVEDGA  180
			  	181  LAATQFHPEKSGDAGAAVLSSWVDGL

Known structures in the PDB
No Known structures
1 21 41 61 81 101 121 141 161 181 201 Range: 7 to 205  |  Coverage: 96% GATase Range: 5 to 200  |  Coverage: 94% 1 Range: 1 to 206  |  Coverage: 99% 1
Number of amino acids : 206
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GATasePF001177-205
Mtb Structural Proteome models
Model Number1
Model nameRv1602
Template1KA9    HPDBCREDO
Template coverage4_191
Template Identity(%)39.9
Model coverage(%)94.7
Normalized DOPE score-0.453

Structure Models from Chopin
Model Number1
Profilec.23.16.1 - 3.40.50.880
Click for model details
zscore19.91
Residue begin1
Residue end206
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1602Gene nameConfidence Score
Rv1599hisD0.999
Rv1601hisB0.999
Rv1603hisA0.999
Rv1605hisF0.999
Rv1606hisI0.998
Rv2121chisG0.996
Rv1600hisC10.996
Rv2121chisG0.996
Rv0013trpG0.968
Rv3772hisC20.96
Rv0957purH0.959
Rv0957purH0.959
Rv1612trpB0.957
Rv1609trpE0.954
Rv1609trpE0.954
Rv1611trpC0.946
Rv0777purB0.942
Rv0777purB0.942
Rv2192ctrpD0.934
Rv2192ctrpD0.934
Rv2584capt0.929
Rv2580chisS0.926
Rv2580chisS0.926
Rv3838cpheA0.914
Rv3838cpheA0.914
Rv2210cilvE0.911
Rv0808purF0.911
Rv0808purF0.911
Rv3002cilvN0.903
Rv3002cilvN0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
imidazole glycerol phosphatePubChem0.977238.135
PRFARPubChem0.967577.331
5-aminoimidazole-4-carboxamide ribosidePubChem0.958338.211
aminoimidazole carboxamide ribonucleotidePubChem0.958338.211
Chebi:17805PubChem0.9238.135
indole-3-glycerol phosphatePubChem0.743287.206
L-arogenatePubChem0.734227.214
imidazole acetol phosphatePubChem0.732220.12
arogenatePubChem0.727227.214
IGPSPubChem0.724287.206
histidinol phosphatePubChem0.716221.151
prephenatePubChem0.705226.183