Rv0957

Tuberculist information
Gene namepurH
Protein functionProbable bifunctional purine biosynthesis protein PurH: phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase) (5'-phosphoribosyl-5-aminoimidazole-4-carboxamide formyltransferase) + inosinemonophosphate cyclohydrolase (imp cyclohydrolase) (inosinicase) (imp synthetase) (ATIC)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1068.2
Molecular mass(da)55026.2
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 523
	  		  	1    MSTDDGRRPIRRALISVYDKTGLVDLAQGLSAAGVEIISTGSTAKTIADTGIPVTPVEQL   60
			  	61   TGFPEVLDGRVKTLHPRVHAGLLADLRKSEHAAALEQLGIEAFELVVVNLYPFSQTVESG  120
			  	121  ASVDDCVEQIDIGGPAMVRAAAKNHPSAAVVTDPLGYHGVLAALRAGGFTLAERKRLASL  180
			  	181  AFQHIAEYDIAVASWMQQTLAPEHPVAAFPQWFGRSWRRVAMLRYGENPHQQAALYGDPT  240
			  	241  AWPGLAQAEQLHGKDMSYNNFTDADAAWRAAFDHEQTCVAIIKHANPCGIAISSVSVADA  300
			  	301  HRKAHECDPLSAYGGVIAANTEVSVEMAEYVSTIFTEVIVAPGYAPGALDVLARKKNIRV  360
			  	361  LVAAEPLAGGSELRPISGGLLIQQSDQLDAHGDNPANWTLATGSPADPATLTDLVFAWRA  420
			  	421  CRAVKSNAIVIAADGATVGVGMGQVNRVDAARLAVERGGERVRGAVAASDAFFPFPDGLE  480
			  	481  TLAAAGVTAVVHPGGSVRDEEVTEAAAKAGVTLYLTGARHFAH

Known structures in the PDB
PDB ID3ZZM
Total residue count1046
Number of chains2
MethodX-RAY
Resolution2.2
PDB ID4A1O
Total residue count1046
Number of chains2
MethodX-RAY
Resolution2.48
1 53 105 157 209 261 313 365 417 469 521 Range: 22 to 136  |  Coverage: 21% MGS Range: 141 to 458  |  Coverage: 60% AICARFT_IMPCHas Range: 13 to 523  |  Coverage: 97% 1 Range: 9 to 523  |  Coverage: 98% 1 Range: 168 to 523  |  Coverage: 67% 2 Range: 8 to 203  |  Coverage: 37% 3 Range: 369 to 523  |  Coverage: 29% 4
Number of amino acids : 523
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
MGSPF0214222-136
AICARFT_IMPCHasPF01808141-458
Mtb Structural Proteome models
Model Number1
Model nameRv0957
Template1G8M    APDBCREDO
Template coverage8_593
Template Identity(%)38.2
Model coverage(%)97.5
Normalized DOPE score0.339

Structure Models from Chopin
Model Number1
Profilec.24.1.3, c.97.1.4 - 1.10.287.440, 3.40.140.20, 3.40.50.1380
Click for model details
zscore70.79
Residue begin9
Residue end523
Model Number2
Profilec.97.1.4
Click for model details
zscore43.75
Residue begin168
Residue end523
Model Number3
Profilec.24.1.3
Click for model details
zscore41.93
Residue begin8
Residue end203
Model Number4
Profile3.40.140.20
Click for model details
zscore23.23
Residue begin369
Residue end523
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0957Gene nameConfidence Score
Rv0956purN0.999
Rv0772purD0.998
Rv0772purD0.998
Rv0772purD0.998
Rv0777purB0.998
Rv0357cpurA0.998
Rv0777purB0.998
Rv3356cfolD0.997
Rv3356cfolD0.997
Rv3275cpurE0.996
Rv3411cguaB20.996
Rv3411cguaB20.996
Rv0808purF0.996
Rv0808purF0.996
Rv3276cpurK0.995
Rv0389purT0.992
Rv0809purM0.991
Rv0809purM0.991
Rv2584capt0.99
Rv1093glyA10.989
Rv0070cglyA20.988
Rv3396cguaA0.986
Rv3396cguaA0.986
Rv3396cguaA0.986
Rv3624chpt0.983
Rv0788purQ0.982
Rv0780purC0.974
Rv1843cguaB10.972
Rv1843cguaB10.972
Rv1021Rv10210.968
Rv1605hisF0.966
Rv2139pyrD0.965
Rv2211cgcvT0.963
Rv2211cgcvT0.963
Rv1602hisH0.959
Rv1383carA0.954
Rv1383carA0.954
Rv0803purL0.945
Rv0803purL0.945
Rv0382cpyrE0.94
Rv3410cguaB30.939
Rv0189cilvD0.938
Rv2124cmetH0.931
Rv2124cmetH0.931
Rv2124cmetH0.931
Rv2124cmetH0.931
Rv2124cmetH0.931
Rv1380pyrB0.929
Rv1380pyrB0.929
Rv1379pyrR0.927
Rv1384carB0.926
Rv1384carB0.926
Rv1384carB0.926
Rv1384carB0.926
Rv0787ARv0787A0.912
Rv2763cdfrA0.912
Rv0952sucD0.907
Rv0952sucD0.907
Rv2904crplS0.905
Rv1699pyrG0.904
Rv1699pyrG0.904
Rv0350dnaK0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
aminoimidazole carboxamide ribonucleotidePubChem0.99338.211
5-aminoimidazole-4-carboxamide ribosidePubChem0.99338.211
xanthosine 5'-phosphatePubChem0.974364.205
xanthosine monophosphatePubChem0.974364.205
5-formamidoimidazole-4-carboxamide ribotidePubChem0.969366.221
FAIPubChem0.968366.221
phosphatePubChem0.96296.9872
SAICARPubChem0.955454.283
adenylosuccinatePubChem0.952463.293
inosine monophosphatePubChem0.95348.206
10-formyltetrahydrofolatePubChem0.945473.439
tetrahydrofolatePubChem0.94445.429
fumaratePubChem0.935116.072
hydroxyl radicalsPubChem0.90717.0073
guanosine diphosphatePubChem0.904443.201
NAD+PubChem0.903663.425
H(+)PubChem0.9022.01588
H4FPubChem0.9445.429
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
10-formyltetrahydropteroylglutamic acidPubChem0.9473.439
deuteriumPubChem0.92.01588
xanthosine-5'-phosphatePubChem0.9364.205
aspartatePubChem0.9133.103
NSC292227PubChem0.9338.211
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
protiumPubChem0.92.01576
guanosine triphosphatePubChem0.9523.18
5'-P-ribosyl-4-(N-succinocarboxamide)-5-aminoimidazolePubChem0.9454.283
potassium aspartatePubChem0.9133.103
potassiumPubChem0.80539.0983
potassium hydridePubChem0.79240.1062
Heterocycle, 1PubChem0.74188.165
compound CPubChem0.74399.488
93APubChem0.737400.259
methotrexatePubChem0.731454.439
2b1gPubChem0.73320.279
guanylatePubChem0.712363.221
SB203580PubChem0.706377.435