Rv0808

Tuberculist information
Gene namepurF
Protein functionAmidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)902.111
Molecular mass(da)56129.6
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 527
	  		  	1    VAVDSDYVTDRAAGSRQTVTGQQPEQDLNSPREECGVFGVWAPGEDVAKLTYYGLYALQH   60
			  	61   RGQEAAGIAVADGSQVLVFKDLGLVSQVFDEQTLAAMQGHVAIGHCRYSTTGDTTWENAQ  120
			  	121  PVFRNTAAGTGVALGHNGNLVNAAALAARARDAGLIATRCPAPATTDSDILGALLAHGAA  180
			  	181  DSTLEQAALDLLPTVRGAFCLTFMDENTLYACRDPYGVRPLSLGRLDRGWVVASETAALD  240
			  	241  IVGASFVRDIEPGELLAIDADGVRSTRFANPTPKGCVFEYVYLARPDSTIAGRSVHAARV  300
			  	301  EIGRRLARECPVEADLVIGVPESGTPAAVGYAQESGVPYGQGLMKNAYVGRTFIQPSQTI  360
			  	361  RQLGIRLKLNPLKEVIRGKRLIVVDDSIVRGNTQRALVRMLREAGAVELHVRIASPPVKW  420
			  	421  PCFYGIDFPSPAELIANAVENEDEMLEAVRHAIGADTLGYISLRGMVAASEQPTSRLCTA  480
			  	481  CFDGKYPIELPRETALGKNVIEHMLANAARGAALGELAADDEVPVGR

Known structures in the PDB
No Known structures
1 53 105 157 209 261 313 365 417 469 521 Range: 88 to 235  |  Coverage: 27% GATase_6 Range: 293 to 415  |  Coverage: 23% Pribosyltran Range: 35 to 498  |  Coverage: 87% 1 Range: 35 to 155  |  Coverage: 22% 1 Range: 1 to 58  |  Coverage: 10% 2 Range: 293 to 415  |  Coverage: 23% 3
Number of amino acids : 527
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
GATase_6PF1352288-235
PribosyltranPF00156293-415
Mtb Structural Proteome models
Model Number1
Model nameRv0808
Template1AO0    APDBCREDO
Template coverage1_457
Template Identity(%)43.7
Model coverage(%)87.9
Normalized DOPE score-0.257

Structure Models from Chopin
Model Number1
Profiled.153.1.1
Click for model details
zscore23.39
Residue begin35
Residue end155
Model Number2
Profilec.61.1.1, d.153.1.1 - 3.40.50.2020, 3.60.20.10
Click for model details
zscore11.35
Residue begin1
Residue end58
Model Number3
Profilec.61.1.1 - 3.40.50.2020
Click for model details
zscore5.44
Residue begin293
Residue end415
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0808Gene nameConfidence Score
Rv0809purM0.999
Rv0809purM0.999
Rv0772purD0.999
Rv0772purD0.999
Rv0772purD0.999
Rv1384carB0.997
Rv1384carB0.997
Rv1384carB0.997
Rv1384carB0.997
Rv3275cpurE0.996
Rv0957purH0.996
Rv0957purH0.996
Rv0777purB0.995
Rv0777purB0.995
Rv1383carA0.995
Rv3276cpurK0.995
Rv1383carA0.995
Rv0788purQ0.991
Rv0956purN0.99
Rv3396cguaA0.99
Rv3396cguaA0.99
Rv3396cguaA0.99
Rv1017cprsA0.988
Rv1017cprsA0.988
Rv0780purC0.979
Rv0803purL0.978
Rv0803purL0.978
Rv0357cpurA0.973
Rv2220glnA10.972
Rv2220glnA10.972
Rv3436cglmS0.969
Rv3436cglmS0.969
Rv2222cglnA20.969
Rv2222cglnA20.969
Rv3858cgltD0.95
Rv3858cgltD0.95
Rv3859cgltB0.95
Rv3859cgltB0.95
Rv3859cgltB0.95
Rv3859cgltB0.95
Rv3858cgltD0.95
Rv2139pyrD0.948
Rv1699pyrG0.946
Rv1699pyrG0.946
Rv0389purT0.943
Rv3411cguaB20.933
Rv3411cguaB20.933
Rv0787ARv0787A0.932
Rv1658argG0.929
Rv3455ctruA0.928
Rv2201asnB0.923
Rv2201asnB0.923
Rv2860cglnA40.915
Rv2860cglnA40.915
Rv1602hisH0.911
Rv0382cpyrE0.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
guanylatePubChem0.994363.221
phosphoribosylpyrophosphatePubChem0.989390.07
adenosine monophosphatePubChem0.988347.221
inosine monophosphatePubChem0.974348.206
adenosine diphosphatePubChem0.968427.201
phosphoribosylaminePubChem0.962229.125
glycinamide ribonucleotidePubChem0.96286.176
polyglutaminePubChem0.954146.145
pyrophosphatePubChem0.943177.975
5-phosphoribosylaminePubChem0.937229.125
D-ribose 5-phosphatePubChem0.933230.11
phosphatePubChem0.92396.9872
glutamatePubChem0.905147.129
adenosine triphosphatePubChem0.903507.181
Fe(III)PubChem0.90355.845
polysulfurPubChem0.996.195
polyglycinePubChem0.975.0666
glutaminPubChem0.9146.145
deuteriumPubChem0.92.01588
RIBOSE-15-BISPHOSPHATEPubChem0.9310.09
protiumPubChem0.92.01576
hydroxyl radicalsPubChem0.917.0073
NSC333308PubChem0.9286.176
H(+)PubChem0.92.01588
ribose 1,5-bisphosphatePubChem0.9310.09
magnesiumPubChem0.81624.305
hypoxanthinePubChem0.8136.111
adeninePubChem0.789135.127
5'-phosphoribosylformylglycinamidinePubChem0.78313.202
FGAMPubChem0.775312.194
aminoimidazolePubChem0.77483.0919
4Fe-4SPubChem0.70688.9179