Rv2222c

Tuberculist information
Gene nameglnA2
Protein functionProbable glutamine synthetase GlnA2 (glutamine synthase) (GS-II)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2492.4
Molecular mass(da)49607.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 446
	  		  	1    MDRQKEFVLRTLEERDIRFVRLWFTDVLGFLKSVAIAPAELEGAFEEGIGFDGSSIEGFA   60
			  	61   RVSESDTVAHPDPSTFQVLPWATSSGHHHSARMFCDITMPDGSPSWADPRHVLRRQLTKA  120
			  	121  GELGFSCYVHPEIEFFLLKPGPEDGSVPVPVDNAGYFDQAVHDSALNFRRHAIDALEFMG  180
			  	181  ISVEFSHHEGAPGQQEIDLRFADALSMADNVMTFRYVIKEVALEEGARASFMPKPFGQHP  240
			  	241  GSAMHTHMSLFEGDVNAFHSADDPLQLSEVGKSFIAGILEHACEISAVTNQWVNSYKRLV  300
			  	301  QGGEAPTAASWGAANRSALVRVPMYTPHKTSSRRVEVRSPDSACNPYLTFAVLLAAGLRG  360
			  	361  VEKGYVLGPQAEDNVWDLTPEERRAMGYRELPSSLDSALRAMEASELVAEALGEHVFDFF  420
			  	421  LRNKRTEWANYRSHVTPYELRTYLSL

Known structures in the PDB
No Known structures
1 45 89 133 177 221 265 309 353 397 441 Range: 16 to 100  |  Coverage: 18% Gln-synt_N Range: 106 to 357  |  Coverage: 56% Gln-synt_C Range: 4 to 446  |  Coverage: 99% 1 Range: 3 to 446  |  Coverage: 99% 1 Range: 106 to 446  |  Coverage: 76% 2 Range: 108 to 357  |  Coverage: 55% 3 Range: 4 to 108  |  Coverage: 23% 4
Number of amino acids : 446
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Gln-synt_NPF0395116-100
Gln-synt_CPF00120106-357
Mtb Structural Proteome models
Model Number1
Model nameRv2222c
Template1F52    APDBCREDO
Template coverage1_468
Template Identity(%)37.5
Model coverage(%)99.1
Normalized DOPE score-0.35

Structure Models from Chopin
Model Number1
Profiled.128.1.1, d.15.9.1 - 3.10.20.70, 3.30.590.10
Click for model details
zscore68.41
Residue begin3
Residue end446
Model Number2
Profiled.128.1.1
Click for model details
zscore55.6
Residue begin106
Residue end446
Model Number3
Profile3.30.590.10
Click for model details
zscore52.96
Residue begin108
Residue end357
Model Number4
Profiled.15.9.1
Click for model details
zscore22.15
Residue begin4
Residue end108
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2222cGene nameConfidence Score
Rv3859cgltB0.985
Rv3859cgltB0.985
Rv3859cgltB0.985
Rv3859cgltB0.985
Rv3858cgltD0.979
Rv3858cgltD0.979
Rv3858cgltD0.979
Rv2221cglnE0.972
Rv2221cglnE0.972
Rv1383carA0.97
Rv1383carA0.97
Rv0808purF0.969
Rv0808purF0.969
Rv2391sirA0.968
Rv2391sirA0.968
Rv3704cgshA0.966
Rv2211cgcvT0.952
Rv2211cgcvT0.952
Rv1384carB0.951
Rv1384carB0.951
Rv1384carB0.951
Rv1384carB0.951
Rv3436cglmS0.95
Rv3436cglmS0.95
Rv2919cglnB0.947
Rv2201asnB0.939
Rv2201asnB0.939
Rv1538cansA0.935
Rv2992cgltS0.934
Rv0252nirB0.933
Rv0252nirB0.933
Rv0252nirB0.933
Rv0252nirB0.933
Rv0252nirB0.933
Rv2476cgdh0.931
Rv3432cgadB0.927
Rv2920camt0.925
Rv0253nirD0.924
Rv0075Rv00750.922
Rv2294Rv22940.914
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
ammoniaPubChem0.95817.0305
glutamatePubChem0.952147.129
polyglutaminePubChem0.941146.145
adenosine diphosphatePubChem0.914427.201
phosphatePubChem0.90796.9872
glutaminPubChem0.9146.145
protiumPubChem0.92.01576
deuteriumPubChem0.92.01588
H(+)PubChem0.92.01588
adenosine triphosphatePubChem0.9507.181