Rv1384

Tuberculist information
Gene namecarB
Protein functionProbable carbamoyl-phosphate synthase large chain CarB (carbamoyl-phosphate synthetase ammonia chain)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1557.1
Molecular mass(da)118929
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 1115
	  		  	1    VPRRTDLHHVLVIGSGPIVIGQACEFDYSGTQACRVLRAEGLQVSLVNSNPATIMTDPEF   60
			  	61   ADHTYVEPITPAFVERVIAQQAERGNKIDALLATLGGQTALNTAVALYESGVLEKYGVEL  120
			  	121  IGADFDAIQRGEDRQRFKDIVAKAGGESARSRVCFTMAEVRETVAELGLPVVVRPSFTMG  180
			  	181  GLGSGIAYSTDEVDRMAGAGLAASPSANVLIEESIYGWKEFELELMRDGHDNVVVVCSIE  240
			  	241  NVDPMGVHTGDSVTVAPAMTLTDREYQRMRDLGIAILREVGVDTGGCNIQFAVNPRDGRL  300
			  	301  IVIEMNPRVSRSSALASKATGFPIAKIAAKLAIGYTLDEIVNDITGETPACFEPTLDYVV  360
			  	361  VKAPRFAFEKFPGADPTLTTTMKSVGEAMSLGRNFVEALGKVMRSLETTRAGFWTAPDPD  420
			  	421  GGIEEALTRLRTPAEGRLYDIELALRLGATVERVAEASGVDPWFIAQINELVNLRNELVA  480
			  	481  APVLNAELLRRAKHSGLSDHQIASLRPELAGEAGVRSLRVRLGIHPVYKTVDTCAAEFEA  540
			  	541  QTPYHYSSYELDPAAETEVAPQTERPKVLILGSGPNRIGQGIEFDYSCVHAATTLSQAGF  600
			  	601  ETVMVNCNPETVSTDYDTADRLYFEPLTFEDVLEVYHAEMESGSGGPGVAGVIVQLGGQT  660
			  	661  PLGLAHRLADAGVPIVGTPPEAIDLAEDRGAFGDLLSAAGLPAPKYGTATTFAQARRIAE  720
			  	721  EIGYPVLVRPSYVLGGRGMEIVYDEETLQGYITRATQLSPEHPVLVDRFLEDAVEIDVDA  780
			  	781  LCDGAEVYIGGIMEHIEEAGIHSGDSACALPPVTLGRSDIAKVRKATEAIAHGIGVVGLL  840
			  	841  NVQYALKDDVLYVLEANPRASRTVPFVSKATAVPLAKACARIMLGATIAQLRAEGLLAVT  900
			  	901  GDGAHAARNAPIAVKEAVLPFHRFRRADGAAIDSLLGPEMKSTGEVMGIDRDFGSAFAKS  960
			  	961  QTAAYGSLPAQGTVFVSVANRDKRSLVFPVKRLADLGFRVLATEGTAEMLRRNGIPCDDV 1020
			  	1021 RKHFEPAQPGRPTMSAVDAIRAGEVNMVINTPYGNSGPRIDGYEIRSAAVAGNIPCITTV 1080
			  	1081 QGASAAVQGIEAGIRGDIGVRSLQELHRVIGGVER

Known structures in the PDB
No Known structures
1 112 223 334 445 556 667 778 889 1000 1111 Range: 6 to 128  |  Coverage: 10% CPSase_L_chain Range: 133 to 340  |  Coverage: 18% CPSase_L_D2 Range: 426 to 549  |  Coverage: 11% CPSase_L_D3 Range: 564 to 683  |  Coverage: 10% CPSase_L_chain Range: 688 to 891  |  Coverage: 18% CPSase_L_D2 Range: 985 to 1078  |  Coverage: 8% MGS Range: 1 to 111  |  Coverage: 9% 1 Range: 1 to 123  |  Coverage: 10% 1 Range: 426 to 549  |  Coverage: 11% 2 Range: 985 to 1078  |  Coverage: 8% 3 Range: 133 to 340  |  Coverage: 18% 4 Range: 688 to 895  |  Coverage: 18% 5 Range: 1 to 123  |  Coverage: 10% 6 Range: 564 to 686  |  Coverage: 10% 7
Number of amino acids : 1115
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
CPSase_L_chainPF002896-128
CPSase_L_D2PF02786133-340
CPSase_L_D3PF02787426-549
CPSase_L_chainPF00289564-683
CPSase_L_D2PF02786688-891
MGSPF02142985-1078
Mtb Structural Proteome models
Model Number1
Model nameRv1384
Template1A9X    APDBCREDO
Template coverage1_1073
Template Identity(%)53.4
Model coverage(%)99.5
Normalized DOPE score-0.843

Structure Models from Chopin
Model Number1
Profilea.92.1.1, c.24.1.1, c.30.1.1, d.142.1.2 - 1.10.1030.10, 3.30.1490.20, 3.30.470.20, 3.40.50.1380, 3.40.50.20
Click for model details
zscore34.88
Residue begin1
Residue end123
Model Number2
Profilea.92.1.1
Click for model details
zscore24.67
Residue begin426
Residue end549
Model Number3
Profilec.24.1.1
Click for model details
zscore22.07
Residue begin985
Residue end1078
Model Number4
Profiled.142.1.2
Click for model details
zscore18.25
Residue begin133
Residue end340
Model Number5
Profiled.142.1.2
Click for model details
zscore18.25
Residue begin688
Residue end895
Model Number6
Profilec.30.1.1
Click for model details
zscore13.99
Residue begin1
Residue end123
Model Number7
Profilec.30.1.1
Click for model details
zscore13.99
Residue begin564
Residue end686
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1384Gene nameConfidence Score
Rv1383carA0.999
Rv1380pyrB0.999
Rv1380pyrB0.999
Rv1383carA0.999
Rv1656argF0.998
Rv1656argF0.998
Rv1658argG0.997
Rv0808purF0.997
Rv0808purF0.997
Rv2139pyrD0.996
Rv1381pyrC0.992
Rv1659argH0.986
Rv1659argH0.986
Rv1379pyrR0.981
Rv1385pyrF0.967
Rv3436cglmS0.953
Rv3436cglmS0.953
Rv2222cglnA20.951
Rv2222cglnA20.951
Rv3859cgltB0.948
Rv3859cgltB0.948
Rv3859cgltB0.948
Rv3859cgltB0.948
Rv0382cpyrE0.945
Rv1080cgreA0.942
Rv1080cgreA0.942
Rv1653argJ0.942
Rv2220glnA10.938
Rv2220glnA10.938
Rv0957purH0.926
Rv0957purH0.926
Rv3396cguaA0.925
Rv3396cguaA0.925
Rv3396cguaA0.925
Rv3858cgltD0.922
Rv3858cgltD0.922
Rv3858cgltD0.922
Rv1654argB0.916
Rv2860cglnA40.904
Rv2860cglnA40.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
carbamoyl phosphatePubChem0.981141.02
polyglutaminePubChem0.978146.145
ornithinePubChem0.828132.161
polyuridylic acidPubChem0.77324.181
manganesePubChem0.71354.938
potassiumPubChem0.7139.0983
chloridePubChem0.70735.453
2-amino-4-(2-amino-2-carboxy-ethyl)sulfanylcarbonyl-butanoic AcidPubChem0.702250.272
potassium hydridePubChem0.70240.1062
hydron diphosphatePubChem0.702391.981
tetraethylammoniumPubChem0.702130.251
DB01974PubChem0.702263.271
inosine monophosphatePubChem0.702348.206
(2R)-2-amino-3-[[(3R)-5-[(1S)-1-amino-2-hydroxy-2-keto-ethyl]-4-isoxazolin-3-yl]thio]propionic acidPubChem0.702263.271
phosphatePubChem0.70296.9872
adenosine diphosphatePubChem0.702427.201
AMPPNPPubChem0.702506.196