Rv3858c

Tuberculist information
Gene namegltD
Protein functionProbable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate synthase) (glutamate synthase (NADH)) (GLTS beta chain) (NADPH-GOGAT)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)4330.04
Molecular mass(da)53451.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 488
	  		  	1    MADPGGFLKYTHRKLPKRRPVPLRLRDWREVYEEFDNESLRQQATRCMDCGIPFCHNGCP   60
			  	61   LGNLIPEWNDLVRRGRWRDAIERLHATNNFPDFTGRLCPAPCEPACVLGINQDPVTIKQI  120
			  	121  ELEIIDKAFDEGWVQPRPPRKLTGQTVAVVGSGPAGLAAAQQLTRAGHTVTVFEREDRIG  180
			  	181  GLLRYGIPEFKMEKRHLDRRLDQMRSEGTEFRPGVNVGVDISAEKLRADFDAVVLAGGAT  240
			  	241  AWRELPIPGRELEGVHQAMEFLPWANRVQEGDDVLDEDGQPPITAKGKKVVIIGGGDTGA  300
			  	301  DCLGTVHRQGAIAVHQFEIMPRPPDARAESTPWPTYPLMYRVSAAHEEGGERVFSVNTEA  360
			  	361  FVGTDGRVSALRAHEVTMLDGKFVKVEGSDFELEADLVLLAMGFVGPERAGLLTDLGVKF  420
			  	421  TERGNVARGDDFDTSVPGVFVAGDMGRGQSLIVWAIAEGRAAAAAVDRYLMGSSALPAPV  480
			  	481  KPTAAPLQ

Known structures in the PDB
No Known structures
1 49 97 145 193 241 289 337 385 433 481 Range: 24 to 133  |  Coverage: 22% Fer4_20 Range: 146 to 450  |  Coverage: 62% Pyr_redox_2 Range: 146 to 217  |  Coverage: 14% Pyr_redox Range: 27 to 482  |  Coverage: 93% 1 Range: 1 to 488  |  Coverage: 99% 1 Range: 1 to 148  |  Coverage: 30% 2 Range: 233 to 406  |  Coverage: 35% 3 Range: 93 to 385  |  Coverage: 59% 4
Number of amino acids : 488
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Fer4_20PF1469124-133
Pyr_redox_2PF07992146-450
Pyr_redoxPF00070146-217
Mtb Structural Proteome models
Model Number1
Model nameRv3858c
Template1GTE    APDBCREDO
Template coverage58_519
Template Identity(%)20.4
Model coverage(%)93.2
Normalized DOPE score-0.131

Structure Models from Chopin
Model Number1
Profilea.1.2.2, c.1.4.1, c.3.1.1, d.58.1.5 - 1.10.1060.10, 3.20.20.70, 3.30.70.20, 3.50.50.60
Click for model details
zscore44.14
Residue begin1
Residue end488
Model Number2
Profilea.1.2.2
Click for model details
zscore14.87
Residue begin1
Residue end148
Model Number3
Profilec.3.1.1
Click for model details
zscore12.23
Residue begin233
Residue end406
Model Number4
Profilec.3.1.6 - 3.50.50.60
Click for model details
zscore10.44
Residue begin93
Residue end385
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3858cGene nameConfidence Score
Rv3859cgltB0.999
Rv3859cgltB0.999
Rv3859cgltB0.999
Rv3859cgltB0.999
Rv2220glnA10.982
Rv2220glnA10.982
Rv2222cglnA20.979
Rv2222cglnA20.979
Rv1383carA0.97
Rv1383carA0.97
Rv0808purF0.95
Rv0808purF0.95
Rv2476cgdh0.949
Rv3436cglmS0.941
Rv3436cglmS0.941
Rv2860cglnA40.938
Rv2860cglnA40.938
Rv3432cgadB0.925
Rv1384carB0.922
Rv1384carB0.922
Rv1384carB0.922
Rv1384carB0.922
Rv2967cpca0.918
Rv2967cpca0.918
Rv2967cpca0.918
Rv2967cpca0.918
Rv2967cpca0.918
Rv2967cpca0.918
Rv0896gltA20.91
Rv1240mdh0.91
Rv1240mdh0.91
Rv1878glnA30.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
glutamatePubChem0.964147.129
alpha-ketoglutaratePubChem0.907146.098
deuteriumPubChem0.92.01588
glutaminPubChem0.9146.145
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
polyglutaminePubChem0.9146.145
NAD+PubChem0.9663.425
H(+)PubChem0.92.01588
protiumPubChem0.92.01576