SInCRe - Rv3432c

Tuberculist information

Gene name	gadB
Protein function	Probable glutamate decarboxylase GadB
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	3850.37
Molecular mass(da)	50747.7
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 460

	  		  	1    VSRSHPSVPAHSIAPAYTGRMFTAPVPALRMPDESMDPEAAYRFIHDELMLDGSSRLNLA   60
			  	61   TFVTTWMDPEAEKLMAETFDKNMIDKDEYPATAAIEARCVSMVADLFHAEGLRDHDPTSA  120
			  	121  TGVSTIGSSEAVMLGGLALKWRWRQRVGSWKGRMPNLVMGSNVQVVWEKFCRYFDVEPRY  180
			  	181  LPMERGRYVITPEQVLAAVDENTIGVVAILGTTYTGELEPIAEICAALDKLAAGGGVDVP  240
			  	241  VHVDAASGGFVVPFLHPDLVWDFRLPRVVSINVSGHKYGLTYPGVGFVVWRGPEHLPEDL  300
			  	301  VFRVNYLGGDMPTFTLNFSRPGNQVVGQYYNFLRLGRDGYTKVMQALSHTARWLGDQLRE  360
			  	361  VDHCEVISDGSAIPVVSFRLAGDRGYTEFDVSHELRTFGWQVPAYTMPDNATDVAVLRIV  420
			  	421  VREGLSADLARALHDDAVTALAALDKVKPGGHFDAQHFAH

Known structures in the PDB

No Known structures

Number of amino acids : 460

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
Pyridoxal_deC	PF00282	32-381

Mtb Structural Proteome models

Model Number	1
Model name	Rv3432c
Template	2DGK APDB CREDO
Template coverage	29_465
Template Identity(%)	49.0
Model coverage(%)	93.9
Normalized DOPE score	-0.655

Structure Models from Chopin

Model Number	1
Profile	c.67.1.6 Click for model details
zscore	52.11
Residue begin	1
Residue end	450

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv3432c	Gene name	Confidence Score
Rv3859c	gltB	0.973
Rv3859c	gltB	0.973
Rv3859c	gltB	0.973
Rv3859c	gltB	0.973
Rv2589	gabT	0.96
Rv2858c	aldC	0.937
Rv0458	Rv0458	0.936
Rv2220	glnA1	0.932
Rv2220	glnA1	0.932
Rv0768	aldA	0.931
Rv2222c	glnA2	0.927
Rv2222c	glnA2	0.927
Rv3858c	gltD	0.925
Rv3858c	gltD	0.925
Rv3858c	gltD	0.925
Rv0147	Rv0147	0.924
Rv1187	rocA	0.917
Rv2860c	glnA4	0.908
Rv2860c	glnA4	0.908
Rv2394	ggtB	0.906
Rv0773c	ggtA	0.903
Rv3406	Rv3406	0.901

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
glutamatePubChem	0.98	147.129
gamma-aminobutyric acidPubChem	0.976	103.12
phosphorylethanolaminePubChem	0.91	141.063
sphingosine 1-phosphatePubChem	0.907	379.472
carbon dioxidePubChem	0.905	44.0095
hexadecenalPubChem	0.9	238.409
cysteine sulfinic acidPubChem	0.9	153.157
palmitoylPubChem	0.9	240.425
pyridoxal phosphatePubChem	0.9	247.142
cysteatePubChem	0.9	169.156
taurinePubChem	0.9	125.147
protiumPubChem	0.9	2.01576
dihydrosphingosine-1-phosphatePubChem	0.9	381.488
cysteic acidPubChem	0.9	169.156
alpha-ketoglutaratePubChem	0.9	146.098
deuteriumPubChem	0.9	2.01588
H(+)PubChem	0.9	2.01588
beta-alaninePubChem	0.9	89.0932
succinic semialdehydePubChem	0.9	102.089
cysteinesulfinic acidPubChem	0.9	152.149
aspartatePubChem	0.9	133.103
acetatePubChem	0.714	59.044
hydride acetatePubChem	0.708	61.0599