Rv3406

Tuberculist information
Gene nameRv3406
Protein functionProbable dioxygenase
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)3825.33
Molecular mass(da)32578.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 295
	  		  	1    MTDLITVKKLGSRIGAQIDGVRLGGDLDPAAVNEIRAALLAHKVVFFRGQHQLDDAEQLA   60
			  	61   FAGLLGTPIGHPAAIALADDAPIITPINSEFGKANRWHTDVTFAANYPAASVLRAVSLPS  120
			  	121  YGGSTLWANTAAAYAELPEPLKCLTENLWALHTNRYDYVTTKPLTAAQRAFRQVFEKPDF  180
			  	181  RTEHPVVRVHPETGERTLLAGDFVRSFVGLDSHESRVLFEVLQRRITMPENTIRWNWAPG  240
			  	241  DVAIWDNRATQHRAIDDYDDQHRLMHRVTLMGDVPVDVYGQASRVISGAPMEIAG

Known structures in the PDB
PDB ID4FFA
Total residue count1192
Number of chains4
MethodX-RAY
Resolution2.5
1 30 59 88 117 146 175 204 233 262 291 Range: 6 to 269  |  Coverage: 89% TauD Range: 4 to 287  |  Coverage: 95% 1 Range: 4 to 294  |  Coverage: 98% 1
Number of amino acids : 295
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
TauDPF026686-269
Mtb Structural Proteome models
Model Number1
Model nameRv3406
Template1OIH    APDBCREDO
Template coverage14_299
Template Identity(%)55.2
Model coverage(%)95.9
Normalized DOPE score-0.482

Structure Models from Chopin
Model Number1
Profile3.60.130.10
Click for model details
zscore59.38
Residue begin4
Residue end294
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3406Gene nameConfidence Score
Rv2394ggtB0.92
Rv0773cggtA0.912
Rv3432cgadB0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
taurinePubChem0.983125.147
bisulfitePubChem0.95180.0632
alpha-ketoglutaratePubChem0.876146.098
Fe(III)PubChem0.86555.845
succinatePubChem0.716118.088