SInCRe - Rv2394

Tuberculist information

Gene name	ggtB
Protein function	Probable gamma-glutamyltranspeptidase precursor GgtB (gamma-glutamyltransferase) (glutamyl transpeptidase)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	2688.01
Molecular mass(da)	66527.5
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 643

	  		  	1    VSVWLRAGALVAAVMLSLSGCGGFHAGAPSTAGPCEIVPNGTPAPKTPPATVPSSRNLAT   60
			  	61   NPEIATGYRRDMTVVRTAHYAAATANPLATQVACRVLRDGGTAADAVVAAQAVLGLVEPQ  120
			  	121  SSGIGGGGYLVYFDARTGSVQAYDGREVAPAAATENYLRWVSDVDRSAPRPNARASGRSI  180
			  	181  GVPGILRMLEMVHNEHGRTPWRDLFGPAVTLADGGFDISARMGAAISDAAPQLRDDPEAR  240
			  	241  KYFLNPDGSPKPAGTRLTNPAYSKTLSAIASAGANAFYSGDIAHDIVAAASDTSNGRTPG  300
			  	301  LLTIEDLAGYLAKRRQPLCTTYRGREICGMPSSGGVAVAATLGILEHFPMSDYAPSKVDL  360
			  	361  NGGRPTVMGVHLIAEAERLAYADRDQYIADVDFVRLPGGSLTTLVDPGYLAARAALISPQ  420
			  	421  HSMGSARPGDFGAPTAVAPPVPEHGTSHLSVVDSYGNAATLTTTVESSFGSYHLVDGFIL  480
			  	481  NNQLSDFSAEPHATDGSPVANRVEPGKRPRSSMAPTLVFDHSSAGRGALYAVLGSPGGSM  540
			  	541  IIQFVVKTLVAMLDWGLNPQQAVSLVDFGAANSPHTNLGGENPEINTSDDGDHDPLVQGL  600
			  	601  RALGHRVNLAEQSSGLSAITRSEAGWAGGADPRREGAVMGDDA

Known structures in the PDB

No Known structures

Number of amino acids : 643

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
G_glu_transpept	PF01019	94-636

Mtb Structural Proteome models

Model Number	1
Model name	Rv2394
Template	2DG5 APDB CREDO
Template coverage	44_385
Template Identity(%)	34.8
Model coverage(%)	56.6
Normalized DOPE score	0.409

Model Number	2
Model name	Rv2394.2
Template	2DG5 BPDB CREDO
Template coverage	391_579
Template Identity(%)	37.0
Model coverage(%)	30.2
Normalized DOPE score	0.788

Structure Models from Chopin

Model Number	1
Profile	d.153.1.6 Click for model details
zscore	66.79
Residue begin	59
Residue end	643

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv2394	Gene name	Confidence Score
Rv2213	pepB	0.95
Rv2213	pepB	0.95
Rv0266c	oplA	0.931
Rv0266c	oplA	0.931
Rv0266c	oplA	0.931
Rv1848	ureA	0.923
Rv2855	mtr	0.922
Rv2855	mtr	0.922
Rv2855	mtr	0.922
Rv3406	Rv3406	0.92
Rv3432c	gadB	0.906

Potential ligand/drug binding sites

Protein Model	Pocket Number	Drug Binding Site	PMIN Score	Pvalue PMIN	PMAX Score	Pvalue PMAX
Rv2394.2	5	3mg0_BO2_V_1401 PDB CREDO	0.617	0.160	0.588	0.003
Rv2394.2	3	3ut5_LOC_B_502 PDB CREDO	0.800	0.025	0.587	0.003
Rv2394.2	4	3ads_IMN_B_3 PDB CREDO	0.586	0.196	0.586	0.003
Rv2394.2	4	1ie4_T44_A_128 PDB CREDO	0.636	0.138	0.585	0.003
Rv2394.2	3	2nni_MTK_A_501 PDB CREDO	0.729	0.060	0.584	0.003
Rv2394.2	5	3mg0_BO2_H_1400 PDB CREDO	0.635	0.139	0.578	0.003
Rv2394.2	3	2v0z_C41_O_1327 PDB CREDO	0.577	0.208	0.577	0.003
Rv2394.2	4	2itz_IRE_A_2021 PDB CREDO	0.652	0.122	0.576	0.003
Rv2394.2	4	2ity_IRE_A_2020 PDB CREDO	0.676	0.100	0.573	0.003
Rv2394.2	5	3ue0_AZR_A_998 PDB CREDO	0.600	0.178	0.573	0.003
Rv2394.2	4	4dta_ADN_A_401 PDB CREDO	0.616	0.160	0.564	0.004
Rv2394.2	4	3r9c_ECL_A_452 PDB CREDO	0.586	0.197	0.561	0.004
Rv2394.2	4	1uay_ADN_A_1001 PDB CREDO	0.638	0.136	0.559	0.004
Rv2394.2	4	1jg3_ADN_B_550 PDB CREDO	0.682	0.095	0.556	0.005
Rv2394.2	4	1m17_AQ4_A_999 PDB CREDO	0.604	0.174	0.555	0.005
Rv2394.2	4	1ict_T44_C_128 PDB CREDO	0.603	0.175	0.554	0.005
Rv2394.2	4	2ceo_T44_A_1395 PDB CREDO	0.575	0.210	0.550	0.005
Rv2394.2	3	3ut5_LOC_D_502 PDB CREDO	0.796	0.026	0.549	0.005
Rv2394.2	3	1sa1_POD_B_700 PDB CREDO	0.704	0.078	0.548	0.005
Rv2394.2	4	2ceo_T44_B_1395 PDB CREDO	0.572	0.214	0.548	0.005
Rv2394.2	3	1sa1_POD_D_701 PDB CREDO	0.723	0.064	0.546	0.005
Rv2394.2	5	1lik_ADN_A_699 PDB CREDO	0.570	0.217	0.542	0.006
Rv2394.2	4	1sn5_T3_C_601 PDB CREDO	0.565	0.223	0.542	0.006
Rv2394.2	4	2riw_T44_A_1395 PDB CREDO	0.562	0.228	0.538	0.006
Rv2394.2	4	3kw2_ADN_B_300 PDB CREDO	0.634	0.141	0.537	0.006
Rv2394.2	4	3lfa_1N1_A_361 PDB CREDO	0.557	0.234	0.534	0.007
Rv2394.2	4	1ie4_T44_B_328 PDB CREDO	0.654	0.121	0.533	0.007
Rv2394.2	3	2v0z_C41_C_1328 PDB CREDO	0.575	0.210	0.532	0.007
Rv2394.2	4	2xn7_T44_A_1355 PDB CREDO	0.603	0.175	0.532	0.007
Rv2394.2	4	2uxo_TAC_B_1211 PDB CREDO	0.599	0.180	0.529	0.007
Rv2394.2	5	3ndv_AIC_C_375 PDB CREDO	0.554	0.238	0.528	0.007
Rv2394.2	5	3ny4_SMX_A_308 PDB CREDO	0.553	0.240	0.527	0.007
Rv2394.2	5	1lii_ADN_A_699 PDB CREDO	0.552	0.241	0.526	0.007
Rv2394.2	5	3ndv_AIC_A_375 PDB CREDO	0.552	0.242	0.526	0.007
Rv2394.2	4	1jg3_ADN_A_500 PDB CREDO	0.721	0.066	0.525	0.007
Rv2394.2	4	2uxp_CLM_B_1211 PDB CREDO	0.598	0.181	0.524	0.008
Rv2394.2	4	2xn6_T44_A_1370 PDB CREDO	0.593	0.187	0.523	0.008
Rv2394.2	4	1sn0_T44_C_601 PDB CREDO	0.571	0.216	0.523	0.008
Rv2394.2	4	2ito_IRE_A_2020 PDB CREDO	0.662	0.113	0.520	0.008
Rv2394.2	4	1sn5_T3_D_602 PDB CREDO	0.566	0.223	0.518	0.008
Rv2394.2	4	2uxp_CLM_A_1211 PDB CREDO	0.592	0.189	0.518	0.008
Rv2394.2	4	3mdz_EZL_A_264 PDB CREDO	0.518	0.291	0.518	0.008
Rv2394.2	4	3adx_IMN_B_3 PDB CREDO	0.586	0.196	0.518	0.008
Rv2394.2	4	2ydo_ADN_A_400 PDB CREDO	0.538	0.261	0.515	0.009
Rv2394.2	3	3sm2_478_A_126 PDB CREDO	0.554	0.238	0.513	0.009
Rv2394.2	4	3uq6_ADN_A_401 PDB CREDO	0.614	0.163	0.512	0.009
Rv2394.2	5	3ndv_AIC_B_376 PDB CREDO	0.559	0.232	0.508	0.010
Rv2394.2	3	1hwk_117_B_1 PDB CREDO	0.614	0.162	0.507	0.010
Rv2394.2	4	3sxr_1N1_B_2 PDB CREDO	0.574	0.211	0.507	0.010
Rv2394.2	4	3oht_1N1_A_1000 PDB CREDO	0.671	0.105	0.507	0.010
Rv2394.2	5	3ndv_AIC_D_374 PDB CREDO	0.556	0.235	0.506	0.010
Rv2394.2	4	3kw2_ADN_A_300 PDB CREDO	0.669	0.107	0.505	0.010
Rv2394.2	4	1r9o_FLP_A_501 PDB CREDO	0.577	0.207	0.505	0.010
Rv2394.2	4	3ubo_ADN_B_353 PDB CREDO	0.505	0.310	0.505	0.010
Rv2394.2	4	3uq6_ADN_B_401 PDB CREDO	0.605	0.173	0.505	0.010
Rv2394.2	5	3ue0_AZR_B_999 PDB CREDO	0.688	0.091	0.503	0.010
Rv2394.2	4	3q1e_T44_D_328 PDB CREDO	0.502	0.315	0.502	0.011
Rv2394.2	4	4dt8_ADN_A_401 PDB CREDO	0.548	0.246	0.502	0.011
Rv2394.2	4	3f4x_KLT_A_300 PDB CREDO	0.640	0.134	0.502	0.011
Rv2394.2	4	3s20_CER_B_1 PDB CREDO	0.630	0.145	0.501	0.011

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
glutamatePubChem	0.981	147.129
cysteinylglycinePubChem	0.941	178.21
Cys-GlyPubChem	0.94	178.21
reduced glutathionePubChem	0.923	307.323
taurinePubChem	0.9	125.147
acivicinPubChem	0.865	178.574