Rv2213

Tuberculist information
Gene namepepB
Protein functionProbable aminopeptidase PepB
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)2478.34
Molecular mass(da)53449.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 515
	  		  	1    VTTEPGYLSPSVAVATSMPKRGVGAAVLIVPVVSTGEEDRPGAVVASAEPFLRADTVAEI   60
			  	61   EAGLRALDATGASDQVHRLAVPSLPVGSVLTVGLGKPRREWPADTIRCAAGVAARALNSS  120
			  	121  EAVITTLAELPGDGICSATVEGLILGSYRFSAFRSDKTAPKDAGLRKITVLCCAKDAKKR  180
			  	181  ALHGAAVATAVATARDLVNTPPSHLFPAEFAKRAKTLSESVGLDVEVIDEKALKKAGYGG  240
			  	241  VIGVGQGSSRPPRLVRLIHRGSRLAKNPQKAKKVALVGKGITFDTGGISIKPAASMHHMT  300
			  	301  SDMGGAAAVIATVTLAARLRLPIDVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNT  360
			  	361  DAEGRLILADAIVRACEDKPDYLIETSTLTGAQTVALGTRIPGVMGSDEFRDRVAAISQR  420
			  	421  VGENGWPMPLPDDLKDDLKSTVADLANVSGQRFAGMLVAGVFLREFVAESVDWAHIDVAG  480
			  	481  PAYNTGSAWGYTPKGATGVPTRTMFAVLEDIAKNG

Known structures in the PDB
No Known structures
1 52 103 154 205 256 307 358 409 460 511 Range: 29 to 157  |  Coverage: 24% Peptidase_M17_N Range: 191 to 506  |  Coverage: 61% Peptidase_M17 Range: 37 to 512  |  Coverage: 92% 1 Range: 11 to 515  |  Coverage: 97% 1 Range: 191 to 506  |  Coverage: 61% 2 Range: 29 to 157  |  Coverage: 24% 3 Range: 11 to 193  |  Coverage: 35% 4
Number of amino acids : 515
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Peptidase_M17_NPF0278929-157
Peptidase_M17PF00883191-506
Mtb Structural Proteome models
Model Number1
Model nameRv2213
Template1GYT    APDBCREDO
Template coverage11_497
Template Identity(%)36.6
Model coverage(%)92.2
Normalized DOPE score-0.337

Structure Models from Chopin
Model Number1
Profilec.50.1.1, c.56.5.3 - 3.40.220.10, 3.40.630.10
Click for model details
zscore73.05
Residue begin11
Residue end515
Model Number2
Profilec.56.5.3
Click for model details
zscore64.57
Residue begin191
Residue end506
Model Number3
Profile3.40.220.10
Click for model details
zscore16.45
Residue begin29
Residue end157
Model Number4
Profile3.40.220.10
Click for model details
zscore10.38
Residue begin11
Residue end193
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2213Gene nameConfidence Score
Rv0733adk0.98
Rv0946cpgi0.979
Rv2394ggtB0.95
Rv0773cggtA0.932
Rv1240mdh0.926
Rv1240mdh0.926
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
bestatinPubChem0.932308.373
Cys-GlyPubChem0.923178.21
cysteinylglycinePubChem0.92178.21
half-cystinePubChem0.901121.158
polyglycinePubChem0.975.0666
zincPubChem0.88165.409
Na(+)PubChem0.84122.9898
magnesiumPubChem0.83224.305
bicarbonatePubChem0.80262.0248
chloridePubChem0.79735.453
sulfatePubChem0.79496.0626
hydron sulfatePubChem0.794196.157
manganesePubChem0.79154.938
DB07448PubChem0.741361.372
potassiumPubChem0.72739.0983
diethylene glycolPubChem0.723106.12
potassium hydridePubChem0.72340.1062
amastatinPubChem0.721474.548
polyethylene glycolPubChem0.71462.0678
ethylene glycol; hydronPubChem0.71463.0758
L-leucinePubChem0.706131.173