Rv0733

Tuberculist information
Gene nameadk
Protein functionAdenylate kinase Adk (ATP-AMP transphosphorylase)
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)826.122
Molecular mass(da)20092.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 181
	  		  	1    VRVLLLGPPGAGKGTQAVKLAEKLGIPQISTGELFRRNIEEGTKLGVEAKRYLDAGDLVP   60
			  	61   SDLTNELVDDRLNNPDAANGFILDGYPRSVEQAKALHEMLERRGTDIDAVLEFRVSEEVL  120
			  	121  LERLKGRGRADDTDDVILNRMKVYRDETAPLLEYYRDQLKTVDAVGTMDEVFARALRALG  180
			  	181  K

Known structures in the PDB
PDB ID1P4S
Total residue count181
Number of chains1
MethodNMR
ResolutionN/A
PDB ID2CDN
Total residue count201
Number of chains1
MethodX-RAY
Resolution1.9
1 19 37 55 73 91 109 127 145 163 181 Range: 5 to 160  |  Coverage: 85% ADK Range: to 4  |  Coverage: 2% 1 Range: 1 to 181  |  Coverage: 99% 2 Range: 1 to 181  |  Coverage: 99% 1
Number of amino acids : 181
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ADKPF004065-160
Mtb Structural Proteome models
Model Number1
Model nameRv0733_2cdn_A
Template2CDN    APDBCREDO
Template coverage0_181
Template Identity(%)100.0
Model coverage(%)100.0
Normalized DOPE score-2.344

Model Number2
Model nameRv0733
Template2CDN    APDBCREDO
Template coverage1_181
Template Identity(%)100.0
Model coverage(%)99.4
Normalized DOPE score-1.927

Structure Models from Chopin
Model Number1
Profilec.37.1.1 - 3.40.50.300
Click for model details
zscore9.73
Residue begin1
Residue end181
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0733Gene nameConfidence Score
Rv0732secY0.998
Rv0734mapA0.998
Rv2445cndkA0.995
Rv1617pykA0.994
Rv1617pykA0.994
Rv2584capt0.988
Rv3624chpt0.987
Rv2861cmapB0.986
Rv1309atpG0.985
Rv2783cgpsI0.984
Rv2783cgpsI0.984
Rv0723rplO0.984
Rv2783cgpsI0.984
Rv1308atpA0.984
Rv1308atpA0.984
Rv2783cgpsI0.984
Rv1308atpA0.984
Rv2783cgpsI0.984
Rv0777purB0.982
Rv0777purB0.982
Rv1341Rv13410.981
Rv2213pepB0.98
Rv2213pepB0.98
Rv3051cnrdE0.979
Rv3458crpsD0.979
Rv3458crpsD0.979
Rv3051cnrdE0.979
Rv3051cnrdE0.979
Rv0701rplC0.978
Rv3457crpoA0.978
Rv3457crpoA0.978
Rv3457crpoA0.978
Rv3459crpsK0.977
Rv1311atpC0.977
Rv0684fusA10.976
Rv0684fusA10.976
Rv0684fusA10.976
Rv0684fusA10.976
Rv0684fusA10.976
Rv0946cpgi0.972
Rv3628ppa0.971
Rv1310atpD0.969
Rv1310atpD0.969
Rv1310atpD0.969
Rv3460crpsM0.969
Rv3048cnrdF20.966
Rv3456crplQ0.965
Rv0704rplB0.964
Rv0704rplB0.964
Rv0721rpsE0.963
Rv0721rpsE0.963
Rv1240mdh0.963
Rv1240mdh0.963
Rv0682rpsL0.962
Rv2202cadoK0.962
Rv3462cinfA0.961
Rv1389gmk0.96
Rv0716rplE0.959
Rv0716rplE0.959
Rv0639nusG0.959
Rv0639nusG0.959
Rv0719rplF0.958
Rv0718rpsH0.957
Rv0714rplN0.957
Rv0570nrdZ0.955
Rv0570nrdZ0.955
Rv0570nrdZ0.955
Rv1981cnrdF10.953
Rv0703rplW0.953
Rv0685tuf0.953
Rv0685tuf0.953
Rv0685tuf0.953
Rv0705rpsS0.953
Rv0707rpsC0.951
Rv3068cpgmA0.951
Rv0702rplD0.951
Rv0707rpsC0.951
Rv3068cpgmA0.951
Rv0652rplL0.951
Rv3068cpgmA0.951
Rv3068cpgmA0.951
Rv0667rpoB0.949
Rv0667rpoB0.949
Rv2448cvalS0.949
Rv0667rpoB0.949
Rv2448cvalS0.949
Rv0667rpoB0.949
Rv2448cvalS0.949
Rv0667rpoB0.949
Rv0667rpoB0.949
Rv0700rpsJ0.949
Rv0683rpsG0.947
Rv0720rplR0.946
Rv3309cupp0.945
Rv0357cpurA0.944
Rv0715rplX0.942
Rv0708rplP0.942
Rv0710rpsQ0.937
Rv0717rpsN10.934
Rv3396cguaA0.932
Rv3396cguaA0.932
Rv3396cguaA0.932
Rv1306atpF0.928
Rv2889ctsf0.927
Rv0668rpoC0.927
Rv0668rpoC0.927
Rv1437pgk0.927
Rv0668rpoC0.927
Rv0668rpoC0.927
Rv2889ctsf0.927
Rv0668rpoC0.927
Rv0706rplV0.924
Rv3010cpfkA0.924
Rv0641rplA0.921
Rv1304atpB0.92
Rv1436gap0.913
Rv1436gap0.913
Rv3014cligA0.909
Rv3014cligA0.909
Rv3014cligA0.909
Rv3913trxB20.909
Rv3014cligA0.909
Rv3913trxB20.909
Rv3014cligA0.909
Rv1023eno0.907
Rv1023eno0.907
Rv0640rplK0.903
Rv0640rplK0.903
Rv2883cpyrH0.903
Rv2984ppk10.902
Rv2984ppk10.902
Rv2984ppk10.902
Rv1307atpH0.901
Rv1307atpH0.901
Rv3442crpsI0.901
Rv1449ctkt0.901
Rv1449ctkt0.901
Rv1449ctkt0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
adenosine diphosphatePubChem0.999427.201
magnesiumPubChem0.99224.305
adenosine monophosphatePubChem0.986347.221
phosphatePubChem0.97396.9872
adenosine triphosphatePubChem0.965507.181
adenosine(5')pentaphospho(5')adenosinePubChem0.949916.367
dADPPubChem0.942411.202
zincPubChem0.9465.409
deuteriumPubChem0.9342.01588
H(+)PubChem0.9322.01588
Ap5APubChem0.911916.367
protiumPubChem0.92.01576
adenylosuccinatePubChem0.9463.293
hydroxyl radicalsPubChem0.917.0073
fumaratePubChem0.9116.072
sodium orthovanadatePubChem0.856183.908
Ap4APubChem0.823836.387
AMPPNPPubChem0.8506.196
adeninePubChem0.787135.127
sulfatePubChem0.77596.0626
hydron sulfatePubChem0.775196.157
calciumPubChem0.7740.078
nucleoside monophosphatePubChem0.748214.11
poly CPubChem0.74323.197
Ap6APubChem0.717996.347
polyuridylic acidPubChem0.709324.181
adenosine 5'-tetraphosphatePubChem0.701587.161