SInCRe - Rv3309c

Tuberculist information

Gene name	upp
Protein function	Probable uracil phosphoribosyltransferase Upp (UMP pyrophosphorylase) (uprtase) (UMP diphosphorylase)
Functional category(tuberculist)	intermediary metabolism and respiration
Gene location(kb)	3696.47
Molecular mass(da)	21866.2
External sites	TB Database TubercuList WebTB

Protein sequence

Number of amino acids : 207

	  		  	1    VQVHVVDHPLAAARLTTLRDERTDNAGFRAALRELTLLLIYEATRDAPCEPVPIRTPLAE   60
			  	61   TVGSRLTKPPLLVPVLRAGLGMVDEAHAALPEAHVGFVGVARDEQTHQPVPYLDSLPDDL  120
			  	121  TDVPVMVLDPMVATGGSMTHTLGLLISRGAADITVLCVVAAPEGIAALQKAAPNVRLFTA  180
			  	181  AIDEGLNEVAYIVPGLGDAGDRQFGPR

Known structures in the PDB

	PDB ID	2VG2
	Total residue count	1136
	Number of chains	4
	Method	X-RAY
	Resolution	1.95

	PDB ID	2VG3
	Total residue count	1136
	Number of chains	4
	Method	X-RAY
	Resolution	1.8

	PDB ID	2VG4
	Total residue count	1136
	Number of chains	4
	Method	X-RAY
	Resolution	2.6

	PDB ID	4ONC
	Total residue count	568
	Number of chains	2
	Method	X-RAY
	Resolution	1.83

Number of amino acids : 207

Domains assigned based on sequence.

Mtb Structural proteome models

CHOPIN models

Profile-based domain assignment

Structural/Functional domain family	Pfam acc.no./SCOP ID	Domain Region
UPRTase	PF14681	5-206

Mtb Structural Proteome models

Model Number	1
Model name	Rv3309c
Template	1O5O APDB CREDO
Template coverage	6_206
Template Identity(%)	49.0
Model coverage(%)	96.1
Normalized DOPE score	-1.037

Structure Models from Chopin

Model Number	1
Profile	c.61.1.1 - 3.40.50.2020 Click for model details
zscore	11.73
Residue begin	1
Residue end	207

Binding pockets

STRING

Cytoscape Web will replace the contents of this div with protein-protein interaction network.

Protein interacting with Rv3309c	Gene name	Confidence Score
Rv3314c	deoA	0.999
Rv3314c	deoA	0.999
Rv3314c	deoA	0.999
Rv2883c	pyrH	0.994
Rv1379	pyrR	0.992
Rv1385	pyrF	0.99
Rv3315c	cdd	0.987
Rv2584c	apt	0.975
Rv0478	deoC	0.972
Rv2139	pyrD	0.969
Rv2465c	rpiB	0.966
Rv1380	pyrB	0.956
Rv1380	pyrB	0.956
Rv0070c	glyA2	0.952
Rv1093	glyA1	0.95
Rv1017c	prsA	0.95
Rv1017c	prsA	0.95
Rv1383	carA	0.946
Rv1383	carA	0.946
Rv0733	adk	0.945
Rv1021	Rv1021	0.943
Rv0382c	pyrE	0.933
Rv3307	deoD	0.931
Rv2992c	gltS	0.929
Rv3396c	guaA	0.926
Rv3396c	guaA	0.926
Rv3396c	guaA	0.926
Rv1699	pyrG	0.925
Rv1699	pyrG	0.925
Rv2448c	valS	0.922
Rv2448c	valS	0.922
Rv2448c	valS	0.922
Rv1649	pheS	0.92
Rv1649	pheS	0.92
Rv1299	prfA	0.914
Rv1299	prfA	0.914
Rv1712	cmk	0.913
Rv2445c	ndkA	0.912
Rv1298	rpmE	0.903

Potential ligand/drug binding sites

No binding sites identified

Similarity to known drug target from sensitive sequence analysis

No drug targets

List of small molecules tested from TIBLE

Data not available

Off-target activity - ligand based from TIBLE

Data not available

Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.

Data not available

STITCH interactions

Chemical Name	Confidence score	Molecular Weight
polyuridylic acidPubChem	0.989	324.181
pyrophosphatePubChem	0.968	177.975
phosphoribosylpyrophosphatePubChem	0.968	390.07
uracilPubChem	0.955	112.087
cytosinePubChem	0.927	111.102
uridinePubChem	0.901	244.201
ammoniaPubChem	0.9	17.0305
hydroxyl radicalsPubChem	0.9	17.0073
ribose 1-phosphatePubChem	0.9	230.11
phosphatePubChem	0.9	96.9872
hydron sulfatePubChem	0.8	196.157
sulfatePubChem	0.8	96.0626
selenomethioninePubChem	0.702	196.106
SeMetPubChem	0.702	196.106