Rv1093

Tuberculist information
Gene nameglyA1
Protein functionSerine hydroxymethyltransferase 1 GlyA1
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1220.57
Molecular mass(da)45029.4
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 426
	  		  	1    MSAPLAEVDPDIAELLAKELGRQRDTLEMIASENFVPRAVLQAQGSVLTNKYAEGLPGRR   60
			  	61   YYGGCEHVDVVENLARDRAKALFGAEFANVQPHSGAQANAAVLHALMSPGERLLGLDLAN  120
			  	121  GGHLTHGMRLNFSGKLYENGFYGVDPATHLIDMDAVRATALEFRPKVIIAGWSAYPRVLD  180
			  	181  FAAFRSIADEVGAKLLVDMAHFAGLVAAGLHPSPVPHADVVSTTVHKTLGGGRSGLIVGK  240
			  	241  QQYAKAINSAVFPGQQGGPLMHVIAGKAVALKIAATPEFADRQRRTLSGARIIADRLMAP  300
			  	301  DVAKAGVSVVSGGTDVHLVLVDLRDSPLDGQAAEDLLHEVGITVNRNAVPNDPRPPMVTS  360
			  	361  GLRIGTPALATRGFGDTEFTEVADIIATALATGSSVDVSALKDRATRLARAFPLYDGLEE  420
			  	421  WSLVGR

Known structures in the PDB
PDB ID3H7F
Total residue count894
Number of chains2
MethodX-RAY
Resolution1.5
1 43 85 127 169 211 253 295 337 379 421 Range: 5 to 386  |  Coverage: 89% SHMT Range: to 1  |  Coverage: 0% 1 Range: 5 to 410  |  Coverage: 95% 2 Range: 1 to 426  |  Coverage: 99% 1
Number of amino acids : 426
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
SHMTPF004645-386
Mtb Structural Proteome models
Model Number1
Model nameRv1093_3h7f_A
Template3H7F    APDBCREDO
Template coverage0_425
Template Identity(%)100.0
Model coverage(%)99.8
Normalized DOPE score-0.997

Model Number2
Model nameRv1093
Template1KKJ    APDBCREDO
Template coverage4_405
Template Identity(%)58.0
Model coverage(%)95.1
Normalized DOPE score-0.793

Structure Models from Chopin
Model Number1
Profilec.67.1.4
Click for model details
zscore12.07
Residue begin1
Residue end426
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1093Gene nameConfidence Score
Rv3356cfolD0.997
Rv2211cgcvT0.997
Rv3356cfolD0.997
Rv2211cgcvT0.997
Rv1832gcvB0.995
Rv1832gcvB0.995
Rv3042cserB20.993
Rv3042cserB20.993
Rv0957purH0.989
Rv0957purH0.989
Rv2763cdfrA0.982
Rv2764cthyA0.982
Rv2964purU0.981
Rv2964purU0.981
Rv1612trpB0.979
Rv1406fmt0.979
Rv1406fmt0.979
Rv0069csdaA0.968
Rv0069csdaA0.968
Rv2124cmetH0.964
Rv2124cmetH0.964
Rv2124cmetH0.964
Rv2124cmetH0.964
Rv2124cmetH0.964
Rv0956purN0.964
Rv1559ilvA0.957
Rv1559ilvA0.957
Rv0389purT0.955
Rv3309cupp0.95
Rv1023eno0.949
Rv1023eno0.949
Rv1826gcvH0.949
Rv1613trpA0.937
Rv2335cysE0.933
Rv2335cysE0.933
Rv1077cbs0.931
Rv1077cbs0.931
Rv1133cmetE0.928
Rv2614cthrS0.928
Rv2614cthrS0.928
Rv2614cthrS0.928
Rv1133cmetE0.928
Rv2448cvalS0.921
Rv1437pgk0.921
Rv2448cvalS0.921
Rv2448cvalS0.921
Rv1649pheS0.913
Rv1649pheS0.913
Rv2992cgltS0.909
Rv0505cserB10.907
Rv2580chisS0.903
Rv2580chisS0.903
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
tetrahydrofolatePubChem0.983445.429
L-serinePubChem0.973105.093
polyglycinePubChem0.96275.0666
glyoxylatePubChem0.95774.0355
5-methyltetrahydrofolatePubChem0.948459.456
5,10-methylenetetrahydrofolatePubChem0.948457.44
5,10-methenyltetrahydrofolatePubChem0.944456.432
H4FPubChem0.943445.429
methenyltetrahydrofolatePubChem0.934456.432
N5,N10-methylenetetrahydrofolatePubChem0.931457.44
thymidylatePubChem0.93322.208
phosphatePubChem0.92896.9872
homocysteinePubChem0.926135.185
methyltetrahydrofolatePubChem0.925459.456
dUMPPubChem0.921308.182
L-methioninePubChem0.92149.211
pyridoxal phosphatePubChem0.915247.142
L-homocysteinePubChem0.903135.185
dihydrofolatePubChem0.902443.413
NAD+PubChem0.9663.425
DL-serinePubChem0.9105.093
NADPPubChem0.9744.413
O-phosphoserinePubChem0.9185.072
Nchembio861-comp5PubChem0.9377.33
dihydronicotinamide formycin dinucleotidePubChem0.9665.441
hydroxyl radicalsPubChem0.917.0073
magnesiumPubChem0.924.305
reduced nicotinamide adenine dinucleotidePubChem0.9665.441
protiumPubChem0.92.01576
H(+)PubChem0.92.01588
NADP(H)PubChem0.9745.421
deuteriumPubChem0.92.01588
hydroxypyruvatePubChem0.9104.061
5-formyltetrahydrofolatePubChem0.74473.439
folatePubChem0.711441.397
leucovorinPubChem0.71473.439