Rv1613

Tuberculist information
Gene nametrpA
Protein functionProbable tryptophan synthase, alpha subunit TrpA
Functional category(tuberculist)intermediary metabolism and respiration
Gene location(kb)1812.36
Molecular mass(da)27727.7
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 270
	  		  	1    MVAVEQSEASRLGPVFDSCRANNRAALIGYLPTGYPDVPASVAAMTALVESGCDIIEVGV   60
			  	61   PYSDPGMDGPTIARATEAALRGGVRVRDTLAAVEAISIAGGRAVVMTYWNPVLRYGVDAF  120
			  	121  ARDLAAAGGLGLITPDLIPDEAQQWLAASEEHRLDRIFLVAPSSTPERLAATVEASRGFV  180
			  	181  YAASTMGVTGARDAVSQAAPELVGRVKAVSDIPVGVGLGVRSRAQAAQIAQYADGVIVGS  240
			  	241  ALVTALTEGLPRLRALTGELAAGVRLGMSA

Known structures in the PDB
No Known structures
1 28 55 82 109 136 163 190 217 244 271 Range: 16 to 265  |  Coverage: 92% Trp_syntA Range: 14 to 269  |  Coverage: 94% 1 Range: 1 to 270  |  Coverage: 99% 1
Number of amino acids : 270
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
Trp_syntAPF0029016-265
Mtb Structural Proteome models
Model Number1
Model nameRv1613
Template1UJP    APDBCREDO
Template coverage5_254
Template Identity(%)43.2
Model coverage(%)94.4
Normalized DOPE score-1.142

Structure Models from Chopin
Model Number1
Profilec.1.2.4 - 3.20.20.70
Click for model details
zscore28.56
Residue begin1
Residue end270
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1613Gene nameConfidence Score
Rv1611trpC0.999
Rv1612trpB0.999
Rv2192ctrpD0.994
Rv2192ctrpD0.994
Rv1609trpE0.994
Rv1609trpE0.994
Rv3336ctrpS0.959
Rv3042cserB20.956
Rv3042cserB20.956
Rv1559ilvA0.948
Rv1559ilvA0.948
Rv0013trpG0.945
Rv0069csdaA0.94
Rv0069csdaA0.94
Rv0070cglyA20.938
Rv1093glyA10.937
Rv2965ckdtB0.926
Rv1077cbs0.922
Rv1077cbs0.922
Rv2540caroF0.919
Rv0505cserB10.917
Rv2538caroB0.916
Rv2335cysE0.915
Rv3227aroA0.915
Rv2335cysE0.915
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
indole-3-glycerol phosphatePubChem0.988287.206
L-serinePubChem0.983105.093
D-glyceraldehyde-3-phosphatePubChem0.973170.058
indolePubChem0.973117.148
L-tryptophanPubChem0.956204.225
IGPSPubChem0.943287.206
DL-serinePubChem0.94105.093
H(+)PubChem0.92.01588
deuteriumPubChem0.92.01588
protiumPubChem0.92.01576
1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-PPubChem0.9349.23
C01302PubChem0.9349.23
glyceraldehyde-3-phosphatePubChem0.9170.058
hydroxyl radicalsPubChem0.917.0073
carbon dioxidePubChem0.944.0095
pyridoxal phosphatePubChem0.857247.142
hydron sulfatePubChem0.774196.157
sulfatePubChem0.77496.0626
indole-3-propanol phosphatePubChem0.773255.207
anthranilic acidPubChem0.737137.136