Rv3336c

Tuberculist information
Gene nametrpS
Protein functionProbable tryptophanyl-tRNA synthetase TrpS (tryptophan--tRNA ligase) (TRPRS) (tryptophan translase)
Functional category(tuberculist)information pathways
Gene location(kb)3722.62
Molecular mass(da)36272
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 336
	  		  	1    MSTPTGSRRIFSGVQPTSDSLHLGNALGAVAQWVGLQDDHDAFFCVVDLHAITIPQDPEA   60
			  	61   LRRRTLITAAQYLALGIDPGRATIFVQSQVPAHTQLAWVLGCFTGFGQASRMTQFKDKSA  120
			  	121  RQGSEATTVGLFTYPVLQAADVLAYDTELVPVGEDQRQHLELARDVAQRFNSRFPGTLVV  180
			  	181  PDVLIPKMTAKIYDLQDPTSKMSKSAGTDAGLINLLDDPALSAKKIRSAVTDSERDIRYD  240
			  	241  PDVKPGVSNLLNIQSAVTGTDIDVLVDGYAGHGYGDLKKDTAEAVVEFVNPIQARVDELT  300
			  	301  ADPAELEAVLAAGAQRAHDVASKTVQRVYDRLGFLL

Known structures in the PDB
No Known structures
1 34 67 100 133 166 199 232 265 298 331 Range: 3 to 290  |  Coverage: 85% tRNA-synt_1b Range: 8 to 334  |  Coverage: 97% 1 Range: 1 to 336  |  Coverage: 99% 1
Number of amino acids : 336
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
tRNA-synt_1bPF005793-290
Mtb Structural Proteome models
Model Number1
Model nameRv3336c
Template1I6K    APDBCREDO
Template coverage2_324
Template Identity(%)51.4
Model coverage(%)97.0
Normalized DOPE score-1.209

Structure Models from Chopin
Model Number1
Profilec.26.1.1
Click for model details
zscore27.91
Residue begin1
Residue end336
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv3336cGene nameConfidence Score
Rv1689tyrS0.993
Rv1689tyrS0.993
Rv1612trpB0.989
Rv2614cthrS0.981
Rv2614cthrS0.981
Rv2614cthrS0.981
Rv0041leuS0.971
Rv0041leuS0.971
Rv0041leuS0.971
Rv3834cserS0.967
Rv3834cserS0.967
Rv1292argS0.965
Rv1292argS0.965
Rv1292argS0.965
Rv1611trpC0.961
Rv1613trpA0.959
Rv2580chisS0.954
Rv2580chisS0.954
Rv1649pheS0.953
Rv1649pheS0.953
Rv3598clysS0.953
Rv3598clysS0.953
Rv2572caspS0.948
Rv2572caspS0.948
Rv2572caspS0.948
Rv1609trpE0.943
Rv1609trpE0.943
Rv1536ileS0.936
Rv1536ileS0.936
Rv2192ctrpD0.936
Rv2192ctrpD0.936
Rv2448cvalS0.935
Rv2448cvalS0.935
Rv2448cvalS0.935
Rv1633uvrB0.934
Rv1633uvrB0.934
Rv1633uvrB0.934
Rv1633uvrB0.934
Rv0350dnaK0.933
Rv0013trpG0.933
Rv2534cefp0.93
Rv2534cefp0.93
Rv2534cefp0.93
Rv1007cmetS0.925
Rv2404clepA0.924
Rv1408rpe0.924
Rv2404clepA0.924
Rv2404clepA0.924
Rv2404clepA0.924
Rv3442crpsI0.923
Rv3356cfolD0.921
Rv3356cfolD0.921
Rv2533cnusB0.92
Rv0716rplE0.92
Rv0716rplE0.92
Rv2839cinfB0.919
Rv2839cinfB0.919
Rv2839cinfB0.919
Rv2839cinfB0.919
Rv2882cfrr0.916
Rv0056rplI0.915
Rv0056rplI0.915
Rv2538caroB0.913
Rv0070cglyA20.902
Rv2539caroK0.901
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
L-tryptophanPubChem0.99204.225
pyrophosphatePubChem0.931177.975
adenosine triphosphatePubChem0.928507.181
adenosine monophosphatePubChem0.921347.221
glycerolPubChem0.80292.0938
sulfatePubChem0.78896.0626
hydron sulfatePubChem0.788196.157
selenomethioninePubChem0.762196.106
SeMetPubChem0.742196.106
WSAPubChem0.712532.53
calciumPubChem0.70340.078