Rv1633

Tuberculist information
Gene nameuvrB
Protein functionProbable excinuclease ABC (subunit B - helicase) UvrB
Functional category(tuberculist)information pathways
Gene location(kb)1837.07
Molecular mass(da)78038.3
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 698
	  		  	1    VRAGGHFEVVSPHAPAGDQPAAIDELERRINAGERDVVLLGATGTGKSATTAWLIERLQR   60
			  	61   PTLVMAPNKTLAAQLANELREMLPHNAVEYFVSYYDYYQPEAYIAQTDTYIEKDSSINDD  120
			  	121  VERLRHSATSALLSRRDVVVVASVSCIYGLGTPQSYLDRSVELKVGEEVPRDGLLRLLVD  180
			  	181  VQYTRNDMSFTRGSFRVRGDTVEIIPSYEELAVRIEFFGDEIEALYYLHPLTGEVIRQVD  240
			  	241  SLRIFPATHYVAGPERMAHAVSAIEEELAERLAELESQGKLLEAQRLRMRTNYDIEMMRQ  300
			  	301  VGFCSGIENYSRHIDGRGPGTPPATLLDYFPEDFLLVIDESHVTVPQIGGMYEGDISRKR  360
			  	361  NLVEYGFRLPSACDNRPLTWEEFADRIGQTVYLSATPGPYELSQTGGEFVEQVIRPTGLV  420
			  	421  DPKVVVKPTKGQIDDLIGEIRTRADADQRVLVTTLTKKMAEDLTDYLLEMGIRVRYLHSE  480
			  	481  VDTLRRVELLRQLRLGDYDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSSRSLIQTI  540
			  	541  GRAARNVSGEVHMYADKITDSMREAIDETERRRAKQIAYNEANGIDPQPLRKKIADILDQ  600
			  	601  VYREADDTAVVEVGGSGRNASRGRRAQGEPGRAVSAGVFEGRDTSAMPRAELADLIKDLT  660
			  	661  AQMMAAARDLQFELAARFRDEIADLKRELRGMDAAGLK

Known structures in the PDB
No Known structures
1 70 139 208 277 346 415 484 553 622 691 Range: 14 to 137  |  Coverage: 17% ResIII Range: 465 to 547  |  Coverage: 11% Helicase_C Range: 553 to 596  |  Coverage: 6% UvrB Range: 653 to 688  |  Coverage: 5% UVR Range: 6 to 682  |  Coverage: 96% 1 Range: 415 to 559  |  Coverage: 20% 1 Range: 14 to 137  |  Coverage: 17% 2 Range: 647 to 693  |  Coverage: 6% 3 Range: 1 to 698  |  Coverage: 99% 4
Number of amino acids : 698
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
ResIIIPF0485114-137
Helicase_CPF00271465-547
UvrBPF12344553-596
UVRPF02151653-688
Mtb Structural Proteome models
Model Number1
Model nameRv1633
Template2D7D    APDBCREDO
Template coverage4_654
Template Identity(%)62.1
Model coverage(%)96.8
Normalized DOPE score-0.376

Structure Models from Chopin
Model Number1
Profilec.37.1.14 - 3.40.50.300
Click for model details
zscore14.03
Residue begin415
Residue end559
Model Number2
Profilec.37.1.21 - 3.40.50.300
Click for model details
zscore8.65
Residue begin14
Residue end137
Model Number3
Profilea.2.9.1 - 4.10.860.10
Click for model details
zscore6.95
Residue begin647
Residue end693
Model Number4
Profilec.37.1.16, e.10.1.1 - 1.10.290.10, 1.10.460.10, 3.40.50.140, 3.40.50.300
Click for model details
zscore4.76
Residue begin1
Residue end698
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv1633Gene nameConfidence Score
Rv1420uvrC0.999
Rv1420uvrC0.999
Rv1638uvrA0.999
Rv1420uvrC0.999
Rv1420uvrC0.999
Rv2720lexA0.988
Rv2720lexA0.988
Rv2593cruvA0.978
Rv2593cruvA0.978
Rv0949uvrD10.978
Rv0949uvrD10.978
Rv2593cruvA0.978
Rv1696recN0.976
Rv3014cligA0.97
Rv3014cligA0.97
Rv3014cligA0.97
Rv1629polA0.97
Rv3014cligA0.97
Rv1629polA0.97
Rv3014cligA0.97
Rv1629polA0.97
Rv1316cogt0.945
Rv1316cogt0.945
Rv3674cnth0.943
Rv3674cnth0.943
Rv3674cnth0.943
Rv2592cruvB0.942
Rv2592cruvB0.942
Rv1108cxseA0.936
Rv1108cxseA0.936
Rv2594cruvC0.934
Rv3336ctrpS0.934
Rv2737crecA0.927
Rv2737crecA0.927
Rv0003recF0.926
Rv3240csecA10.925
Rv3240csecA10.925
Rv3240csecA10.925
Rv3198cuvrD20.923
Rv3198cuvrD20.923
Rv3198cuvrD20.923
Rv1023eno0.922
Rv1023eno0.922
Rv1437pgk0.919
Rv1634Rv16340.915
Rv0002dnaN0.914
Rv0002dnaN0.914
Rv0002dnaN0.914
Rv2924cfpg0.913
Rv2924cfpg0.913
Rv2924cfpg0.913
Rv3589mutY0.912
Rv3589mutY0.912
Rv3056dinP0.91
Rv2976cung0.91
Rv3056dinP0.91
Rv3715crecR0.909
Rv3715crecR0.909
Rv3715crecR0.909
Rv0629crecD0.906
Rv0629crecD0.906
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
mitomycin CPubChem0.802334.327
AI-2PubChem0.714192.94
4-nitroquinoline 1-oxidePubChem0.707190.156
octyl-beta-D-glucopyranosidePubChem0.707292.369
octylglucosidePubChem0.707292.369
hydron sulfatePubChem0.707196.157
sulfatePubChem0.70796.0626
AK-FLUORPubChem0.704332.306
selenomethioninePubChem0.704196.106
SeMetPubChem0.704196.106
adenosine diphosphatePubChem0.704427.201