Rv2594c

Tuberculist information
Gene nameruvC
Protein functionProbable crossover junction endodeoxyribonuclease RuvC (holliday junction nuclease) (holliday junction resolvase)
Functional category(tuberculist)information pathways
Gene location(kb)2924.82
Molecular mass(da)19753.8
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 188
	  		  	1    VRVMGVDPGLTRCGLSLIESGRGRQLTALDVDVVRTPSDAALAQRLLAISDAVEHWLDTH   60
			  	61   HPEVVAIERVFSQLNVTTVMGTAQAGGVIALAAAKRGVDVHFHTPSEVKAAVTGNGSADK  120
			  	121  AQVTAMVTKILALQAKPTPADAADALALAICHCWRAPTIARMAEATSRAEARAAQQRHAY  180
			  	181  LAKLKAAR

Known structures in the PDB
No Known structures
1 19 37 55 73 91 109 127 145 163 181 Range: 3 to 152  |  Coverage: 79% RuvC Range: 2 to 161  |  Coverage: 84% 1 Range: 1 to 161  |  Coverage: 85% 1
Number of amino acids : 188
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
RuvCPF020753-152
Mtb Structural Proteome models
Model Number1
Model nameRv2594c
Template1HJR    APDBCREDO
Template coverage2_158
Template Identity(%)38.9
Model coverage(%)84.6
Normalized DOPE score-0.586

Structure Models from Chopin
Model Number1
Profilec.55.3.6 - 3.30.420.10
Click for model details
zscore33.97
Residue begin1
Residue end161
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2594cGene nameConfidence Score
Rv2592cruvB0.999
Rv2592cruvB0.999
Rv2593cruvA0.999
Rv2593cruvA0.999
Rv2593cruvA0.999
Rv3715crecR0.981
Rv3715crecR0.981
Rv3715crecR0.981
Rv0003recF0.97
Rv1696recN0.966
Rv2720lexA0.965
Rv2720lexA0.965
Rv0054ssb0.964
Rv2973crecG0.963
Rv2973crecG0.963
Rv2973crecG0.963
Rv0631crecC0.961
Rv0629crecD0.948
Rv0629crecD0.948
Rv0001dnaA0.943
Rv0001dnaA0.943
Rv1633uvrB0.934
Rv1633uvrB0.934
Rv1633uvrB0.934
Rv1633uvrB0.934
Rv0630crecB0.926
Rv0630crecB0.926
Rv0630crecB0.926
Rv1341Rv13410.925
Rv2603cRv2603c0.924
Rv1638uvrA0.923
Rv2150cftsZ0.919
Rv2150cftsZ0.919
Rv1020mfd0.915
Rv1020mfd0.915
Rv1020mfd0.915
Rv1020mfd0.915
Rv1629polA0.904
Rv1629polA0.904
Rv1629polA0.904
Rv2737crecA0.902
Rv2737crecA0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
RuvA proteinPubChem0.807361.48