Rv2592c

Tuberculist information
Gene nameruvB
Protein functionProbable holliday junction DNA helicase RuvB
Functional category(tuberculist)information pathways
Gene location(kb)2923.2
Molecular mass(da)36626.9
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 344
	  		  	1    MTERSDRDVSPALTVGEGDIDVSLRPRSLREFIGQPRVREQLQLVIEGAKNRGGTPDHIL   60
			  	61   LSGPPGLGKTSLAMIIAAELGSSLRVTSGPALERAGDLAAMLSNLVEHDVLFIDEIHRIA  120
			  	121  RPAEEMLYLAMEDFRVDVVVGKGPGATSIPLEVAPFTLVGATTRSGALTGPLRDRFGFTA  180
			  	181  HMDFYEPAELERVLARSAGILGIELGADAGAEIARRSRGTPRIANRLLRRVRDFAEVRAD  240
			  	241  GVITRDVAKAALEVYDVDELGLDRLDRAVLSALTRSFGGGPVGVSTLAVAVGEEAATVEE  300
			  	301  VCEPFLVRAGMVARTPRGRVATALAWTHLGMTPPVGASQPGLFE

Known structures in the PDB
No Known structures
1 35 69 103 137 171 205 239 273 307 341 Range: 7 to 240  |  Coverage: 67% RuvB_N Range: 257 to 332  |  Coverage: 21% RuvB_C Range: 24 to 334  |  Coverage: 90% 1 Range: 12 to 344  |  Coverage: 96% 1 Range: 7 to 240  |  Coverage: 67% 2 Range: 3 to 344  |  Coverage: 99% 3 Range: 258 to 332  |  Coverage: 21% 4
Number of amino acids : 344
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
RuvB_NPF054967-240
RuvB_CPF05491257-332
Mtb Structural Proteome models
Model Number1
Model nameRv2592c
Template1IN4    APDBCREDO
Template coverage19_329
Template Identity(%)53.4
Model coverage(%)90.1
Normalized DOPE score-0.741

Structure Models from Chopin
Model Number1
Profilea.4.5.11, c.37.1.20 - 1.10.10.10, 1.10.8.60, 3.40.50.300
Click for model details
zscore17.64
Residue begin12
Residue end344
Model Number2
Profilec.37.1.20
Click for model details
zscore14.73
Residue begin7
Residue end240
Model Number3
Profilec.37.1.20
Click for model details
zscore11.79
Residue begin3
Residue end344
Model Number4
Profilea.4.5.11
Click for model details
zscore10.55
Residue begin258
Residue end332
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv2592cGene nameConfidence Score
Rv2593cruvA0.999
Rv2593cruvA0.999
Rv2593cruvA0.999
Rv2594cruvC0.999
Rv3715crecR0.985
Rv2973crecG0.985
Rv2973crecG0.985
Rv2973crecG0.985
Rv3715crecR0.985
Rv3715crecR0.985
Rv1696recN0.978
Rv0631crecC0.97
Rv0003recF0.966
Rv2720lexA0.964
Rv2720lexA0.964
Rv0629crecD0.957
Rv0629crecD0.957
Rv2737crecA0.955
Rv2737crecA0.955
Rv1420uvrC0.95
Rv1420uvrC0.95
Rv1420uvrC0.95
Rv1420uvrC0.95
Rv1633uvrB0.942
Rv1633uvrB0.942
Rv1633uvrB0.942
Rv1633uvrB0.942
Rv3610cftsH0.941
Rv3610cftsH0.941
Rv3610cftsH0.941
Rv1638uvrA0.94
Rv1020mfd0.936
Rv1020mfd0.936
Rv1020mfd0.936
Rv1020mfd0.936
Rv2362crecO0.934
Rv2362crecO0.934
Rv0054ssb0.926
Rv0949uvrD10.917
Rv0949uvrD10.917
Rv0630crecB0.915
Rv0630crecB0.915
Rv0630crecB0.915
Rv3198cuvrD20.912
Rv0001dnaA0.912
Rv0001dnaA0.912
Rv3198cuvrD20.912
Rv3198cuvrD20.912
Rv0350dnaK0.907
Rv2225panB0.905
Rv1341Rv13410.904
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
RuvA proteinPubChem0.925361.48
magnesiumPubChem0.85824.305
adenosine diphosphatePubChem0.789427.201
cobaltPubChem0.787117.866
1,6-hexanediolPubChem0.709118.174
hydride acetatePubChem0.70961.0599
adenosine triphosphatePubChem0.709507.181
acetatePubChem0.70959.044
SeMetPubChem0.708196.106
selenomethioninePubChem0.708196.106
adeninePubChem0.704135.127
AMPPNPPubChem0.704506.196