Rv0054

Tuberculist information
Gene namessb
Protein functionSingle-strand binding protein Ssb (helix-destabilizing protein)
Functional category(tuberculist)information pathways
Gene location(kb)58.586
Molecular mass(da)17321.1
External sites TB Database TubercuList WebTB
Protein sequence
Number of amino acids : 164
	  		  	1    VAGDTTITIVGNLTADPELRFTPSGAAVANFTVASTPRIYDRQTGEWKDGEALFLRCNIW   60
			  	61   REAAENVAESLTRGARVIVSGRLKQRSFETREGEKRTVIEVEVDEIGPSLRYATAKVNKA  120
			  	121  SRSGGFGSGSRPAPAQTSSASGDDPWGSAPASGSFGGGDDEPPF

Known structures in the PDB
PDB ID1UE1
Total residue count328
Number of chains2
MethodX-RAY
Resolution2.5
PDB ID1UE5
Total residue count328
Number of chains2
MethodX-RAY
Resolution2.6
PDB ID1UE6
Total residue count656
Number of chains4
MethodX-RAY
Resolution2.7
PDB ID1UE7
Total residue count656
Number of chains4
MethodX-RAY
Resolution3.2
1 17 33 49 65 81 97 113 129 145 161 Range: 4 to 109  |  Coverage: 64% SSB Range: 3 to 120  |  Coverage: 71% 1 Range: 2 to 120  |  Coverage: 71% 2 Range: 1 to 153  |  Coverage: 92% 1
Number of amino acids : 164
Domains assigned based on sequence. Mtb Structural proteome models CHOPIN models
Profile-based domain assignment
Structural/Functional domain familyPfam acc.no./SCOP IDDomain Region
SSBPF004364-109
Mtb Structural Proteome models
Model Number1
Model nameRv0054
Template1X3E    APDBCREDO
Template coverage3_120
Template Identity(%)93.6
Model coverage(%)71.3
Normalized DOPE score-0.729

Model Number2
Model nameRv0054_1ue5_A
Template1UE5    APDBCREDO
Template coverage2_120
Template Identity(%)100.0
Model coverage(%)72.0
Normalized DOPE score-0.109

Structure Models from Chopin
Model Number1
Profileb.40.4.3 - 2.40.50.140
Click for model details
zscore8.1
Residue begin1
Residue end153
Binding pockets
STRING
Cytoscape Web will replace the contents of this div with protein-protein interaction network.
Protein interacting with Rv0054Gene nameConfidence Score
Rv0053rpsF0.989
Rv0055rpsR10.986
Rv0058dnaB0.974
Rv0058dnaB0.974
Rv0058dnaB0.974
Rv0058dnaB0.974
Rv1638uvrA0.974
Rv1696recN0.974
Rv2594cruvC0.964
Rv3715crecR0.951
Rv3715crecR0.951
Rv3715crecR0.951
Rv0056rplI0.95
Rv0056rplI0.95
Rv2593cruvA0.94
Rv2593cruvA0.94
Rv2593cruvA0.94
Rv0006gyrA0.938
Rv0006gyrA0.938
Rv3646ctopA0.937
Rv3646ctopA0.937
Rv3646ctopA0.937
Rv2055crpsR20.931
Rv2973crecG0.929
Rv2973crecG0.929
Rv2973crecG0.929
Rv1420uvrC0.927
Rv1420uvrC0.927
Rv1420uvrC0.927
Rv1420uvrC0.927
Rv2592cruvB0.926
Rv2592cruvB0.926
Rv0003recF0.919
Rv1108cxseA0.918
Rv1108cxseA0.918
Rv2720lexA0.902
Rv2720lexA0.902
Potential ligand/drug binding sites
No binding sites identified
Similarity to known drug target from sensitive sequence analysis
No drug targets
List of small molecules tested from TIBLE
Data not available
Off-target activity - ligand based from TIBLE
Data not available
Small molecules involved in protein-protein complex from TIMBAL .Proteins similar to Mtb based on sequence analysis.
Data not available
STITCH interactions  
Chemical NameConfidence scoreMolecular Weight
cadmiumPubChem0.975232.515
zincPubChem0.90265.409